CAS: 17609-80-2; 4-Amino-3-Chlorophenol

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乙酰胺基苯酚乙酸酯置于盐酸,氯仿,氯体系中,化学反应生成4-氨基-3-氯苯酚
参考文献:Theilacker,Chemische Berichte,1938,Vol. 71,P. 2065,2069
标题:Theilacker,Chemische Berichte,1938,Vol. 71,P. 2065,2069

专利信息

专利号:US-7550510-B2
优先权日:2001-07-06
标 题 :Solid phase synthesis of arylretinamides
发明人：CURLEY JR ROBERT W; MERSHON SERENA M; BARNETT DEREK W; CLAGETT-DAME MARGARET; CHAPMAN JASON S
权利人:WISCONSIN ALUMNI RES FOUND
摘要:A solid phase synthetic method for preparing arylretinamides is provided. The method comprises reacting hexachloroacetone with a solvent-suspended resin-bound triphenylphosphine to provide a suspension comprising an activated chlorinating reagent; reacting retinoic acid with the activated chlorinating reagent to provide retinoyl chloride; adding pyridine and a select arylamine to the resulting mixture; and stirring the resulting mixture for a time and at a temperature sufficient for the select arylamine to react with the retinoyl chloride and provide the arylretinamide. Also provided, are select arylretinamides that can be prepared by the present method, and methods of using such arylretinamides to induce apoptosis in cancer cells.

专利号:US-2004102650-A1
优先权日:2001-07-06
标 题:Solid phase synthesis of arylretinamides

专利号:US-2003105164-A1
优先权日:2001-07-06
标 题 :Solid phase synthesis of arylretinamides

专利号:WO-03003987-A2
优先权日:2001-07-06
标题:Solid phase synthesis of arylretinamides

专利号:US-6696606-B2
优先权日:2001-07-06
标 题 :Solid phase synthesis of arylretinamides

专利号:US-8013153-B2
优先权日:2006-03-23
标 题:Substituted pyrimidine kinase inhibitors
发明人：BUTLER JEANNENE; CONNOLLY PETER J; FUENTES-PESQUERA ANGEL R; GREENBERGER LEE M; HUANG SHENLIN; LAMONTAGNE JR KENNETH R; LI RONGHUA; XU GUOZHANG
权利人:JANSSEN PHARMACEUTICA NV
摘要:The present invention is directed to substituted pyrimidine compounds of formula (I): n nand forms thereof, their synthesis and use for treating a chronic or acute protein kinase mediated disease, disorder or condition.