CAS: 66774-02-5; (2-Chlorophenyl)Diphenylmethanol

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CAS号23593-75-1 克霉唑 | CAS号5162-03-8 2-氯二苯甲酮 | CAS号100-58-3 苯基溴化镁 | CAS号119-61-9 二苯甲酮 | CAS号33432-65-4 lithium,chlorob... | CAS号3509-85-1 1-Chloro-2-(dic... | CAS号71-43-2 苯 | CAS号88-16-4 2-氯三氟甲苯 | CAS号36692-27-0 2-氯苯基溴化镁 | CAS号42074-68-0 2-氯三苯基氯甲烷 | CAS号119-61-9 二苯甲酮 | CAS号5162-03-8 2-氯二苯甲酮 | CAS号1499-10-1 9,10-二苯基蒽 | CAS号23593-75-1 克霉唑 | CAS号77539-21-0 9-ethyl-10-phen... | CAS号90292-76-5 2-benzhydrylben...

克霉唑置于itraconazole,苯甲醇体系中,用 乙腈 作为反应溶剂,化学反应 24.0H,以6%的收率获得产物(2-氯苯基)二苯基甲醇
参考文献:克霉唑和伊曲康唑定量方法的开发及其在治疗孢子丝菌病的新型微乳中的稳定性研究
标题:克霉唑和伊曲康唑定量方法的开发及其在治疗孢子丝菌病的新型微乳中的稳定性研究
摘要:孢子丝菌病在世界范围内发生,由真菌巴西孢子丝菌引起.这种病原体具有很高的人畜共患潜力,主要通过受感染猫科动物的咬伤和抓伤传播.克霉唑和伊曲康唑药物之间的新关联显示对巴西链球菌有效.该结合被配制成含有苯甲醇作为油,Tween® 60 和丙二醇分别作为表面活性剂和助表面活性剂以及水的微乳液.最初,使用差示扫描量热法 (Dsc),热重分析 (Tg),傅里叶变换红外光谱 (Ftir) 和 X 射线粉末衍射 (Pxrd) 研究了克霉唑和伊曲康唑之间的相容性.此外,开发了一种简单有效的分析型 HPLC 方法,可同时测定新型微乳剂中克霉唑和伊曲康唑的浓度.事实证明,所开发的方法对于微乳液的两种组分都是有效,稳健且可重现的.我们还对该配方进行了加速稳定性研究,并将开发的分析方法用于监测活性成分的含量.有趣的是,这些研究导致检测到一种已知的克霉唑降解产物,其结构已通过 NMR 和 Hrms 确认,以及伊曲康
DOI:10.3390/molecules24122333

专利信息

专利号:US-7049394-B2
优先权日:2002-08-19
标题 :Method for preparing free flow resin
发明人：MAIKNER JOHN JOSEPH; KINZEY MARLIN KENNETH; BOHLING JAMES CHARLES
权利人:ROHM & HAAS
摘要:The present invention provides a method for producing a free flowing and/or non clumping resin that includes prior to drying, shrinking the resin under agitation. In one variant of the invention, the is a resin used in solid phase synthesis of peptides. In another aspect the invention provides a process of making a peptide using the free flowing resin described herein, and a polypeptide made using the process. Various therapeutics are then be made using the polypepdite.

专利号:US-12172946-B2
优先权日:2019-01-07
标题:Compound containing diphenylmethane structure and use thereof
发明人：LIANG WEIZHOU; ZHENG QINGQUAN; TANG QI
权利人:GUANGZHOU TROJAN PHARMATEC LTD
摘要:A structure of the compound containing a diphenylmethane structure of the present invention is represented by General Formula (1). The compound containing a diphenylmethane structure of the present invention contains a hydroxyl group, an amino group, a substituted amino group, and an active group, and can be used as an amino acid or peptide C-terminal protection reagent. A peptide synthesis reaction using this protection carrier has a fast reaction speed and a high reagent utilization rate in a suitable solvent system; post-treatment is carried out by means of simple liquid-liquid extraction separation, i.e. effective purification can be carried out, and finally, a product with a high purity can be obtained; and during a synthesis process, the change in solubility is small and an operation process has a strong universality, and therefore, the present method can be developed into a universal production method.

专利号:US-2004076623-A1
优先权日:2000-07-14
标题:Activated modular grafted polymeric surfaces
发明人：EDE NICHOLAS JON; ERCOLE FRANCESCA; TRIBBICK GORDON; SANDAYAKE SAMAN; PERERA SENAKE
摘要:The present invention relates generally to new surfaces for solid phase chemistry applications, more specifically plastics surfaces modified by graft polymerisation for use in chemical synthesis and/or immobilisation of chemical entities and/or compounds. n In particular the invention relates to an activated modular grafted polymeric surface, which is suitable for use as a reagent for solid phase organic synthesis, or as a reagent for the affinity capture, presentation or preparation of biomolecules such as proteins, oligonucleotides, nucleic acids, peptides, and lectins. The grafted polymeric surfaces of the invention are particularly useful as scavenger reagents in combinatorial synthetic protocols, and as affinity reagents in protein purification and proteomics.

专利号:US-7351771-B2
优先权日:2002-12-20
标题:Process for regenerating 2-chlorotrityl resins
发明人：BARLOS KLEOMENIS; KNIPP BERNHARD
权利人:HOFFMANN LA ROCHE
摘要:The present invention relates to a recycling process for the preparation of solid phase bonded 2-chlorotrityl chloride (2-CTC resin) useful for solid phase peptide synthesis, wherein active chloride CTC resin is regenerated by reacting the spent resin with a chlorinating agent in organic solvent.

专利号:CN-113801216-B
优先权日:2020-06-16
标题:A kind of synthesis method of somatostatin

专利号:CN-118878622-A
优先权日:2024-09-27
标 题:Green chemical synthesis method of illegal stand