三溴化磷置于dinitrogen Tetraoxide 氧气体系中,用 Neat (No Solvent) 作为反应溶剂,化学反应生成 三溴氧磷 参考文献:Johnson,C. R.; Nunn,L. G.,Journal Of The American Chemical Society,1941,Vol. 63,P. 141-143 标题:Johnson,C. R.; Nunn,L. G.,Journal Of The American Chemical Society,1941,Vol. 63,P. 141-143
专利信息
专利号:US-4288608-A 优先权日:1978-06-01 标题:Synthesis of anthracyclines 发明人:JOHNSON FRANCIS; KIM KYOUNG S 权利人:RESEARCH CORP 摘要:There is provided a novel method of synthesizing certain heterocyclic quinones. In particular there is provided a novel and regiospecific synthesis of 9-acetyl-6,11-dihydroxy-4-methoxy-7,8,9,10-tetrahydronaphthacene-5,12-quinone (7,9-dideoxydaunomycinone) which is known intermediate in the synthesis of daunomycinone. There is also provided a method of preparing analogs of 7,9-dideoxydaunomycinone which thus provide for the preparation of known and desired analogs of daunomycinone. Daunomycinone is a known compound which is an intermediate in the preparation of the clinically accepted naturally-occurring antitumor antibiotics daunomycin and its derivitive adriamycin.
专利号:US-7202370-B2 优先权日:2003-10-27 标 题 :Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III 发明人:NAIDU RAGINA 权利人:CONOR MEDSYSTEMS INC 摘要:A method is provided for the semi-synthesis of taxane intermediates useful in the preparation of paclitaxel and docetaxel from 9-dihydro-13-acetylbaccatin III. The preparation of a suitably protected baccatin III backbone from 9-dihydro-13-acetylbaccatin III, and the insertion of the phenylisoserine side chain onto the protected baccatin III from 9-dihydro-13-acetylbaccatin III to form the taxane derivatives, paclitaxel and docetaxel is disclosed.
专利号:US-8334381-B2 优先权日:2006-11-16 标题 :Process for the preparation of intermediates useful in the synthesis of imatinib 发明人:FALCHI ALESSANDRO; GRENDELE ENNIO; MOTTERLE RICCARDO; STIVANELLO MARIANO 权利人:FALCHI ALESSANDRO; GRENDELE ENNIO; MOTTERLE RICCARDO; STIVANELLO MARIANO; ITALIANA SINT SPA 摘要:It is the object of the present invention a process for the preparation of 4-methyl-N3-[4-(3-pyridinyl)-2-pyrimidinyl]-1,3-benzenediamine and analogues thereof, intermediates useful for the synthesis of Imatinib, or 4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide.
专利号:US-8420848-B2 优先权日:2009-01-09 标题:Process for the synthesis of beta glycerol phosphate 发明人:KULKARNI YASHWANT 权利人:KULKARNI YASHWANT; SIGMA ALDRICH CO LLC 摘要:The present invention provides methods for the preparation of beta glycerol phosphate and its salts. In particular, the invention provides efficient methods for the synthesis of beta glycerol phosphate of high purity.
专利号:WO-2024018354-A1 优先权日:2022-07-18 标题 :A process for the synthesis of 4-alkoxy-3-hydroxypicolinic acids and intermediates thereof 发明人:MAL SANJIB; SARKAR PARANTAP; PATRA PRANAB KUMAR; KLAUSENER ALEXANDER GUENTHER MARIA 权利人:PI INDUSTRIES LTD 摘要:The present invention discloses a process for the synthesis of 4- alkoxy-3-hydroxypicolinic acids of formula (I) from 2-picolinic acid. The present invention further discloses a process for preparation of compounds of formula (iii) from compounds of formula (ii). The present invention also discloses novel intermediate compounds of formula (iii).
专利号:WO-2010144434-A1 优先权日:2009-06-09 标题 :Derivatives of mefloquine and associated methods for making and using 发明人:DOW GEOFFREY S; MILNER ERIN E; WIPF PETER; MO TINGTING 权利人:US OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY ON BEHALF OF U S; DOW GEOFFREY S; MILNER ERIN E; WIPF PETER; MO TINGTING 摘要:The present invention relates to new mefloquine derivatives and therapeutic compositions comprising one or more mefloquine derivatives. Mefloquine derivatives of the invention have a pentafluorosulfanyl moiety substitution at the 8-position. Certain mefloquine derivatives further include a quinoline methanol moiety substitution at the 4-position. The present invention also relates to new intermediate compounds useful in the synthesis of the mefloquine derivatives, which intermediates also have a pentafluorosulfanyl moiety substitution at the 8-position.
摘要:Sainsbury, M., Science of Synthesis Knowledge Updates, (2010) 1, 226. 摘要:Götzinger, A. C.; Müller, T. J. J., Science of Synthesis Knowledge Updates, (2017) 3, 163. 摘要:Weast, R.C. (ed.). Handbook of Chemistry and Physics. 60th ed. Boca Raton, Florida: CRC Press Inc., 1979., p. B-106 摘要:Kleemann A., Kutscher B., Reichert D., Bossart M., Pharmaceutical Substances, Thieme [Online], Stuttgart, (2025).