CAS: 1030377-33-3; Suvorexant

上下游产品

2,5-dichloro-1,3-benzoxazole 1-(7(R)-methyl-1,4-diazepan-1-yl)-1-[5-methyl-2-(2H-1,2,3-triazole-2-yl)phenyl]methanone 2-(2H-1,2,3-triazol-2-yl)-5-methylbenzoic acid 5-chloro-2-[(5R)-hexahydro-5-methyl-1H-1,4-diazepin-1-yl]benzoxazole

4-[(4-Methoxyphenyl)Methyl]-7-Methyl-2,3,5,6-Tetrahydro-1,4-Diazepine置于盐酸,甲酸,[(1S,2S)-N-(P-Toluensulfonyl)-1,2-Diphenylethanediamine](P-Cymene)Ruthenium (I),Palladium 10% On Activated Carbon,甲酸铵,三乙胺,Sodium Hydroxide体系中,用 甲醇,二氯甲烷,N,N-二甲基乙酰胺,水,甲苯 用作溶剂,化学反应 52.5H,反应生成苏沃雷生
参考文献:一种制备n-杂环化合物的方法
标题:一种制备n-杂环化合物的方法
摘要:本发明提供了一种制备n‑杂环化合物的方法,属于制药技术领域.所述的制备n‑杂环化合物的方法包括:N‑杂环中间体化合物与2‑乙氧基‑5‑氯苯并恶唑在加入酸条件下缩合反应,然后经过后处理,制得化合物(1).本发明的方法简便,可以用于工业化生产.

专利信息

专利号:US-2016168138-A1
优先权日:2013-07-15
标题:Process for the preparation of suvorexant and intermediates useful in the synthesis of suvorexant
发明人：IQBAL JAVED; DAHANUKAR VILAS HARESHWAR; ORUGANTI SRINIVAS; KANDAGATLA BHASKAR
权利人:REDDY S LAB LIMTED DR
摘要:A novel processes for the preparation of suvorexant (formula I), its related compounds and its intermediates that are simple, economical and commercially viable. (I)

专利号:US-10030010-B2
优先权日:2014-08-04
标题:Route of synthesis for the preparation of suvorexant
发明人：BARTH ROLAND; HÖFERL-PRANTZ KATHRIN; RICHTER FRANK; WIDSCHWENTER GERHARD
权利人:SANDOZ AG
摘要:The present invention relates to a process for the preparation of a compound of formula (A), Further, the present invention relates to the respective compound (A) as such and to its use in the preparation of antifungal agent.

专利号:EP-3021851-A2
优先权日:2013-07-15
标 题 :Process for the preparation of suvorexant and intermediates useful in the synthesis of suvorexant

专利号:WO-2016020406-A1
优先权日:2014-08-04
标 题:Novel routes of synthesis for the preparation of suvorexant
发明人：BARTH ROLAND; HÖFERL-PRANTZ KATHRIN; RICHTER FRANK; WIDSCHWENTER GERHARD
权利人:SANDOZ AG
摘要:The present invention relates to a process for the preparation of a compound of formula (Ila') and (II) Further, the present invention relates to a compound of formula (Ila') and to a compound of formula (II) as well as all intermediates prepared during the process for the preparation of compound (Ila') and compound (II).

专利号:WO-2015008218-A3
优先权日:2013-07-15
标 题:Process for the preparation of suvorexant and intermediates useful in the synthesis of suvorexant

专利号:CN-105294583-A
优先权日:2015-10-28
标 题:Synthesis of 5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid