CAS: 165547-79-5; 4-Chloro-3-Nitro-2(1H)-Pyridinone

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参考文献: Inhibitors Of Hif Prolyl Hydroxylase[fr] Inhibiteurs De La Hif Prolyl-Hydroxylase
标题: Inhibitors Of Hif Prolyl Hydroxylase[fr] Inhibiteurs De La Hif Prolyl-Hydroxylase
摘要:本发明涉及式i的化合物或其药用盐,其抑制hif脯氨酸羟化酶,用于增强内源性促红细胞生成素的产生,并用于治疗与内源性促红细胞生成素减少相关的疾病,如贫血和类似疾病,以及包含该化合物和药用载体的药物组合物.

专利信息

专利号:US-2009012088-A1
优先权日:2005-07-26
标 题:Compounds for the Treatment of Neurodegeneration and Stroke
发明人：HERGENROTHER PAUL J; PUTT KARSON S; LIU XIANJUN
权利人:HERGENROTHER PAUL J; PUTT KARSON S; LIU XIANJUN
摘要:Compounds and related methods for synthesis, and the use of compounds for the treatment of neurodegenerative diseases are disclosed. Compounds are disclosed in connection with PARG and/or PARP inhibition. Therapeutic applications are relevant for preventing or inhibiting neurological cell death for a variety of neurodegenerative conditions including Parkinson's disease, ischemia, and stroke. Also disclosed is a high-throughput screen for identifying compounds capable of inhibiting PARG and/or PARP.