CAS: 2140-71-8; 2-Amino-9-((2R,3R,4R,5R)-4-Hydroxy-5-(Hydroxymethyl)-3-Methoxytetrahydrofuran-2-yl)-1H-Purin-6(9H)-One

相似化合物

118-00-3 6979-94-8 38819-10-2

上下游产品

2-amino-2'-O-methyladenosine trimethylsulphonium hydroxide G 6-(tert-Butyl-diphenyl-silanyloxy)-9-((2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-methoxy-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacyclo°Cten-2-yl)-9H-purin-2-ylamine 2-dimethylaminomethylene-2'-O-methylguanosineN2-dimethylaminomethylene-2'-O-methylguanosine 2-(4-monomethoxytrityl)-2'-O-methylguanosineN2-(4-monomethoxytrityl)-2'-O-methylguanosine Pent-4-enoic acid (9-{(2R,3R,4R,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-methoxy-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-amide 2-isobutyryl-2′-O-methylguanosineN2-isobutyryl-2′-O-methylguanosine

鸟苷置于三甲基氯硅烷,三氟甲磺酸三甲基硅酯,氨,六甲基二硅氮烷,Tin(Ll) Chloride,Adenosine Deaminase体系中,用 乙二醇二甲醚,水,二甲基亚砜,N,N-二甲基甲酰胺 用作溶剂,化学反应 90.0H,反应生成2'-甲氧基鸟苷
参考文献:Robins,Morris J.; Hansske,Fritz; Bernier,Salwa E.,Canadian Journal Of Chemistry,1981,Vol. 59,P. 3360-3364
标题:Robins,Morris J.; Hansske,Fritz; Bernier,Salwa E.,Canadian Journal Of Chemistry,1981,Vol. 59,P. 3360-3364

专利信息

专利号:US-10167308-B2
优先权日:2013-09-14
标题:Highly efficient synthesis of long RNA using reverse direction approach
发明人：SRIVASTAVA SURESH C; SRIVASTAVA NAVEEN P
权利人:CHEMGENES CORP
摘要:The present invention relates to novel process of reverse 5′→3′ directed synthesis of RNA oligomers in the range of about 100-mer to about 200-mer has been developed and disclosed. Using that method demonstrated high quality RNA synthesis with coupling efficiency approaching 99%.

专利号:EP-1108724-B1
优先权日:1996-01-16
标题 :Synthesis of methoxy nucleosides and enzymatic nucleic acid molecules
发明人：WINCOTT FRANCINE; BEIGELMANN LEONID; MATULIC-ADAMIC JASENKA; USMAN NASSIM; HAEBERLI PETER; KARPEISKY ALEXANDER; SWEEDLER DAVID; JARVIS THALE; DIRENZO ANTHONY
权利人:SIRNA THERAPEUTICS INC
摘要:This invention relates to chemical synthesis of 2'-O-methyl, 3'-O-methyl and 5'-O-methyl nucleosides, incorporation of novel chemical modifications in enzymatic nucleic acid molecules and improved methods for the synthesis of enzymatic nucleic acid molecules.

专利号:US-12146136-B2
优先权日:2020-03-26
标题:Synthesis of modified oligonucleotides with increased stability
发明人：KHVOROVA ANASTASIA; ROUX LOÃ?C MAURICE RENÉ JEAN; YAMADA KEN
权利人:UNIV MASSACHUSETTS
摘要:This disclosure relates to the synthesis of novel modified oligonucleotides. The synthesis of novel phosphoramidites are also provided.

专利号:US-2024383940-A1
优先权日:2021-03-31
标题 :Synthesis of trinucleotide and tetranucleotide caps for mrna production
发明人：ENDO ATSUSHI
权利人:MODERNA TX INC
摘要:Provided herein are methods of making trinucleotides and tetranucleotides for use as 5′ mRNA caps. The methods utilize a novel “top-downâ€? strategy and provide for synthesis of oligonucleotides with higher yields and increased efficiency compared to traditional methods. A key step of the methods disclosed, herein can also be adapted to utilize a “one-potâ€? approach, resulting in an increase in the yield of the final oligonucleotide product.

专利号:US-11858953-B2
优先权日:2018-04-04
标 题:Compositions and methods for synthesis of phosphorylated molecules
发明人：CHAPUT JOHN; LIAO JEN-YU; BALA SAIKAT
权利人:UNIV CALIFORNIA
摘要:The invention provides compositions and methods for synthesis of phosphorylated organic compounds, including nucleoside triphosphates.

专利号:US-7820810-B2
优先权日:2007-03-19
标 题 :Process for the synthesis of 2′-O-substituted purine nulceosides
发明人：RAVIKUMAR VASULINGA
权利人:ISIS PHARMACEUTICALS INC
摘要:The present invention provides an improved process for the synthesis of 2′-O-substituted purine nucleosides. The process includes anhydro or thioanhydro ring opening of a selected 8,2′-cyclopurine nucleoside with a weak nucleophile in the presence of a Lewis acid ester, followed by reduction to afford the desired 2′-O-substituted purine nucleoside.