CAS: 2411-83-8; Methyl 2,3-Dihydroxybenzoate

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2,3-Dihydroxybenzoic acid methyl iodide methanol methyl 3-hydroxybenzoatemethyl 2-hydroxy-3-(tosyloxy)benzoate O-acetyl-β-D-glucopyranosyloxy)-benzoic acid methyl ester2-acetoxy-3-(tetra-O-acetyl-β-D-glucopyranosyloxy)-benzoic acid methyl ester benzophenone methyl 2,2-diphenylbenzo[d][1,3]dioxole-4-carboxylate

2,2-二甲基-1,3-苯并二恶茂烷置于正丁基锂,四甲基乙二胺,三氟化硼乙醚体系中,用 正己烷,二氯甲烷 用作溶剂,化学反应 46.0H,反应生成2,3-二羟基苯甲酸甲酯
参考文献:使用固定在硅胶上的无味硫醇实际裂解乙缩醛
标题:使用固定在硅胶上的无味硫醇实际裂解乙缩醛
摘要:开发了一种实用,有效且通用的方法,使用在硅胶上官能化的硫醇将各种芳族和脂族缩醛脱保护为相应的邻苯二酚或二醇衍生物.这是著名的商业固载硫醇(silia Mets®thiol)的应用.该过程是温和的,并且可以扩大规模.它不需要惰性气氛,并且观测到干净的转化.此方法适用于具有不同功能的取代1,3-苯并二恶唑和脂族缩醛.它提供了高收率的常规路线的优势,可以在环境温度下进行.
Doi:10.1002/ejoc.201901239

专利信息

专利号:US-10730904-B2
优先权日:2012-11-14
标 题:Method for liquid-phase synthesis of nucleic acid
发明人：NONOGAWA MITSURU; NAGATA TOSHIAKI; SAITO HIDEKI; YASUMA TSUNEO
权利人:TAKEDA PHARMACEUTICALS CO
摘要:In this method, an oligonucleotide represented by formula (II) [wherein Y 1 , Q, Base, r and r′ are each as defined in claim 1 ] is prepared by using, as a synthesis unit, a novel nucleoside monomer compound represented by formula (I) [wherein X, R 1 , Y, Base, Z, Ar, R 2 , R 3 and n are each as defined in claim 1 ]. The novel nucleoside monomer compound is a nucleoside, the base moiety of which is substituted with an aromatic-hydrocarbon-ring-carbonyl or -thiocarbonyl group having at least one hydrophobic group. The method can dispense with column-chromatographic purification in every reaction, and enables base elongation not only in the 3′-direction but also in the 5′-direction, thus attaining efficient liquid-phase mass synthesis of an oligonucleotide.

专利号:US-10799441-B2
优先权日:2011-06-06
标题:Skin treatments containing pyrroloquinoline quinone (PQQ) esters and methods of preparation and use thereof
发明人：LEWIS II JOSEPH ABERNATHY; DINARDO JOSEPH C
权利人:LEWIS II JOSEPH ABERNATHY; DINARDO JOSEPH C; PCR TECH HOLDINGS LC
摘要:The present invention relates to cosmetic or dermatological compositions containing PQQ or its esters, methods of treating or promoting skin changes by topical application of these compositions, and methods of synthesis of PQQ esters. The PQQ ester-containing compositions of the present invention are unexpectedly effective in treating skin, particularly with respect to skin tolerance. When included in a topical composition, the PQQ esters of the present invention have an antioxidant effect that is useful in treating a skin change.

专利号:US-2009326223-A1
优先权日:2006-07-18
标题 :Synthesis of 2-amino-substituted 4-oxo-4h-chromen-8.yl-trifluoro-methanesulfonic acid esters
发明人：GRIFFIN ROGER JOHN; HARDCASTLE IAN ROBERT; DESAGE-EL MURR MARINE; RODRIGUEZ-ARISTEGUI SONSOLES; GOLDING BERNARD THOMAS
权利人:GRIFFIN ROGER JOHN; HARDCASTLE IAN ROBERT; DESAGE-EL MURR MARINE; RODRIGUEZ-ARISTEGUI SONSOLES; GOLDING BERNARD THOMAS
摘要:A method of synthesising a compound of formula (I): wherein R N1 and R N2 are independently selected from hydrogen, an optionally substituted C 1-7 alkyl group, C 3-20 heterocyclyl group, or C 5-20 aryl group, or may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; from a compound of formula (III): comprising the steps of: (a) removing the allyl group from the compound of formula (III) with appropriate reaction conditions to yield a compound of formula (II): and (b) reacting the compound of formula (II) with a triflating agent to yield a compound of formula (I).

专利号:US-2015315229-A1
优先权日:2012-11-14
标 题 :Method for liquid-phase synthesis of nucleic acid

专利号:US-10214555-B2
优先权日:2012-11-14
标题 :Method for liquid-phase synthesis of nucleic acid

专利号:US-2019135852-A1
优先权日:2012-11-14
标题 :Method for liquid-phase synthesis of nucleic acid