CAS: 27523-40-6; 1-[2-(2,4-Dichlorophenyl)-2-[(2,6-Dichlorophenyl)Methoxy]Ethyl]Imidazole

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CAS号2631-72-3 2-溴-2',4'-二氯苯乙酮 | CAS号4252-78-2 2,2',4'-三氯苯乙酮 | CAS号46503-52-0 2'-(1H-咪唑-1-基)-... | CAS号13692-14-3 Alpha-(氯甲基)-2,4... | CAS号24155-42-8 1-(2,4-二氯苯基)-2-... | CAS号2014-83-7 2,6-二氯氯苄

2,2',4'-三氯苯乙酮置于sodium Tetrahydroborate,Sodium Hydride体系中,用 1,4-二氧六环,异丙醇,乙腈,Mineral Oil 用作溶剂,化学反应 3.0H,反应生成异康唑
参考文献:New Copper(II) Complexes With Isoconazole: Synthesis,Structures And Biological Properties
标题:New Copper(II) Complexes With Isoconazole: Synthesis,Structures And Biological Properties
摘要:There Is An Increasing Demand For Novel Metal-Based Complexes With Biologically Relevant Molecules In Technology And Medicine. Three New Cu(II) Coordination Compounds With Antifungal Agent Isoconazole (L),Namely Mononuclear Complexes [cucl2(L)(2)] (1),And [cu(O2Cme)(2)(L)(2)]Center Dot 2H(2)O (2) And Coordination Polymer [cu(Pht)(L)(2)](N) (3) (Where H(2)Pht-O-Phthalic Acid) Were Synthesized And Characterized By Ir Spectroscopy,Thermogravimetric Analysis And X-Ray Crystallography. X-Ray Analysis Showed That In All Complexes,The Isoconazole Is Coordinated To Cu(II) Centres By A N Atom Of The Imidazole Fragment. In Complex I,The Square-Planar Environment Of Cu(II) Atoms Is Completed By Two N Atoms Of Isoconazole And Two Chloride Ligands,Whereas The Cu(II) Atoms Are Coordinated By Two N Atoms From Two Isoconazole Ligands And Two O Atoms From The Different Carboxylate Residues: Acetate In 2 And Phthalate In 3. The Formation Of An Infinite Chain Through The Bridging Phthalate Ligand Is Observed In 3. The Biosynthetic Ability Of Micromycetes Aspergillus Niger Cnmn Fd 10 In The Presence Of The Prepared Complexes 1-3 As Well As The Antifungal Drug Isoconazole Were Studied. Complexes 2 And 3 Accelerate The Biosynthesis Of Enzymes (Beta-Glucosidase,Xylanase And Endoglucanase) By This Fungus. Moreover,A Simplified And Improved Method For The Preparation Of Isoconazole Nitrate Was Developed. (C) 2012 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Poly.2012.10.040

专利信息

专利号:US-10925977-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
发明人：YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

专利号:WO-2025085030-A1
优先权日:2023-10-18
标 题:Synthesis of semisynthetic penicillin derivatives containing hydrazone-derived thiazolidine and imidazole ring
发明人：SARIPINAR EMIN; BURAN SUMEYYE
权利人:ERCIYES UNIV
摘要:The present invention relates to the novel semi-synthetic thiazolidine and imidazole penicillin, pharmaceutically acceptable derivatives thereof and their synthesis method that may cause biologically significant changes by the N-acylation reaction of 6-aminopenicillanic (6-APA) using new trisubstituted thiazolidine and imidazole acetyl chloride derivatives. The invention also relates to pharmaceutical compositions comprising these compounds and their use for therapeutic treatment in the human or animal body.

专利号:WO-2025085026-A1
优先权日:2023-10-18
标 题:Synthesis of semisynthetic penicillin derivatives containing hydrazone-derived thiazolidine and imidazole ring
发明人：SARIPINAR EMIN; BURAN SUMEYYE
权利人:T C ERCIYES UNIV
摘要:The present invention relates to the novel semi-synthetic thiazolidine and imidazole penicillin, pharmaceutically acceptable derivatives thereof and their synthesis method that may cause biologically significant changes by the N-acylation reaction of 6-aminopenicillanic (6-APA) using new trisubstituted thiazolidine and imidazole acetyl chloride derivatives. The invention also relates to pharmaceutical compositions comprising these compounds and their use for therapeutic treatment in the human or animal body.

专利号:US-2024336559-A1
优先权日:2021-10-06
标 题 :Anti-fungals compounds targeting the synthesis of fungal sphingolipids
发明人：OJIMA IWAO; HARANAHALLI KRUPANANDAN; DEL POETA MAURIZIO; GARG ASHNA
权利人:UNIV NEW YORK STATE RES FOUND
摘要:The present invention provides a compound having the structure: n n n n n n n n n n n n wherein n R 3 , R 4 , R 5 , R 6 , and R 7 are each independently, H, halogen, CN, —CF 3 , —OCF 3 , —NO 2 , alkyl, alkenyl, alkynyl, aryl, heteroaryl, heterocycle, —OH, —OAc, —OR 13 , —COR 13 , —CH 2 OR 13 , —SH, —SR 13 , —SO 2 R 13 , —NH 2 , —NHR 13 , —NR 14 R 15 , —NHCOR 12 , or —CONR 14 R 15 ; n R 9 , R 10 , R 11 , and R 12 are each independently, H, CN, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, —OAc, —COR 13 , —SH, —SR 13 , —SO 2 R 13 , —NH 2 , —NHR 13 , —NR 14 R 15 , —NHCOR 12 , or —CONR 14 R 15 ;n wherein each occurrence of R 13 is independently alkyl, alkenyl, alkynyl, aryl, or heteroaryl, wherein each occurrence of R 14 is independently —H, alkyl, alkenyl, alkynyl, aryl, or heteroaryl, wherein each occurrence of R 15 is independently —H, alkyl, alkenyl, alkynyl, aryl, or heteroaryl, n n wherein when R 14 is methyl, R 15 is not methyl; n wherein at least one of R 9 , R 10 , R 11 , and R 12 is not H; n wherein at least one of R 3 , R 4 , R 5 , R 6 , and R 7 is not H.

专利号:US-9382288-B2
优先权日:2010-10-06
标题 :Derivatives of steroid benzylamines, having an antiparasitic antibacterial, antimycotic and/or antiviral action
发明人：BECKER KATJA; KRIEG REIMAR; SCHÖNECKER BRUNO
权利人:BECKER KATJA; KRIEG REIMAR; SCHÖNECKER BRUNO; UNIV GIESSEN JUSTUS LIEBIG
摘要:The present invention relates to compounds derived from steroids of the general formula (I) n nwherein L represents a linker and R # represents a steroid residue, the use of compounds of the general formula (I) in medicine and for the prophylaxis and/or the treatment of infectious diseases. Furthermore described are pharmaceutical compositions containing at least one compound of the general formula (I). A further aspect of the invention relates to the synthesis of said compounds of the general formula (I).

专利号:US-10443047-B2
优先权日:2014-05-01
标题 :Increasing cellular lipid production by increasing the activity of diacylglycerol acyltransferase and decreasing the activity of triacylglycerol lipase
发明人：TSAKRAKLIDES VASILIKI; BREVNOVA ELENA E
权利人:NOVOGY INC
摘要:Disclosed are methods and compositions for increasing the triacylglycerol content of a cell by up-regulating diacylglycerol acyltransferase and down-regulating triacylglycerol lipase. In some embodiments, a DGA1 protein is expressed and a native TGL3 gene is knocked out, thereby increasing the synthesis of triacylglycerol and decreasing its consumption, respectively.