CAS: 29676-71-9; 2-(2-Aminothiazol-4-yl)Acetic Acid

上下游产品

CAS号53266-94-7 2-氨基-4-噻唑乙酸乙酯 | CAS号202408-30-8 2-(2-乙酰氨基噻唑-4-基)乙酸 | CAS号53266-94-7 2-氨基-4-噻唑乙酸乙酯 | CAS号64987-16-2 氨基噻唑乙酸甲酯 | CAS号31119-05-8 2-(2-乙酰氨基噻唑-4-基)乙酸乙酯 | CAS号135285-81-3 2-[[(4-氨基苯基)磺酰基... | CAS号223673-61-8 米拉贝隆 | CAS号1603-91-4 2-氨基-4-甲基噻唑 | CAS号76629-18-0 (2-氨基噻唑-4-基)乙酸甲酯盐酸盐 | CAS号64220-26-4 2-[2-(tritylami...

2-氨基-4-噻唑乙酸乙酯置于sodium Hydroxide体系中,用 甲醇 用作溶剂,化学反应 3.0H,以89.7%的收率获得2-氨基噻唑-4-乙酸
参考文献:Mirabegron合成新方法的研究
标题:Mirabegron合成新方法的研究
摘要:Mirabegron是一种肌肉松弛药,用于治疗膀胱过度活动症.现有的米拉贝隆合成方法生产的中间产物4-(2-((苯乙基氨基)乙基)苯胺,使最终产品的纯化过程复杂化.在这项研究中,我们设计了一种低成本的原料用于米拉贝隆的新合成路线,并以99.6%的纯度和61%的总收率生产米拉贝隆.特别是,这种新的合成路线没有产生副产物4-(2-(苯乙氨基)乙基)苯胺,这大大简化了产物纯化过程.
Doi:10.1002/jhet.2871

专利信息

专利号:US-5942632-A
优先权日:1995-07-28
标题:Solid phase synthesis method
发明人：WANG GARY T
权利人:ABBOTT LAB
摘要:A solid phase synthesis method and intermediates useful in the process are disclosed for the preparation of diamino diol and diamino alcohol inhibitors of HIV protease.

专利号:US-6531470-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:WO-2011114184-A1
优先权日:2010-03-15
标题 :Amides of heterocyclic compounds as trpa1 inhibitors
发明人：CHAUDHARI SACHIN SUNDARLAL; KUMAR SUKEERTHI; THOMAS ABRAHAM; PATIL NISHA PARAG; KADAM ASHOK BHAUSAHEB; WAGHMARE NAYAN TATERAO; KHAIRATKAR-JOSHI NEELIMA; MUKHOPADHYAY INDRANIL
权利人:GLENMARK PHARMACEUTICALS SA; CHAUDHARI SACHIN SUNDARLAL; KUMAR SUKEERTHI; THOMAS ABRAHAM; PATIL NISHA PARAG; KADAM ASHOK BHAUSAHEB; WAGHMARE NAYAN TATERAO; KHAIRATKAR-JOSHI NEELIMA; MUKHOPADHYAY INDRANIL
摘要:Amides of heterocyclic compounds as Transient Receptor Potential subfamily A (TRPA) modulators are provided In particular, compounds described herein are useful for treating or preventing diseases, conditions and/ or disorders modulated by TRPA1 (Transient Receptor Potential subfamily A, member 1) Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPA1. (I).

专利号:US-7982049-B2
优先权日:2001-10-30
标 题:α-form or β-form crystal of acetanilide derivative
发明人：KAWAZOE SOUICHIROU; SAKAMOTO KENICHIROU; AWAMURA YUJI; MARUYAMA TATSUYA; SUZUKI TAKAYUKI; ONDA KENICHI; TAKASU TOSHIYUKI
权利人:ASTELLAS PHARMA INC
摘要:To provide novel crystals useful as an ingredient for the production of a diabetes remedy. The invention is concerned with α-form crystal and β-form crystal of (R)-2-(2-aminothiazol-4-yl)-4′-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide. The α-form crystal does not exhibit hygroscopicity and has stability such that it can be used as a medicine, and is useful for mass synthesis in the industrial production. The β-form crystal does not relatively exhibit hygroscopicity and is also useful as a production intermediate of the α-form crystal.

专利号:US-6562844-B2
优先权日:1998-01-23
标 题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-4500716-A
优先权日:1981-11-19
标题 :Intermediate products for the preparation of Z-cephalosporins
发明人：KINAST GUENTHER
权利人:BAYER AG
摘要:Highly active substantially pure Z-isomers of cephalosporins are produced by the following synthesis: ##STR1## in which R 1 , R 4 and R 5 ae various organic radicals, n R 2 is alkoxycarbonyl, n Y is Cl, Br or --O--SO 2 --R 5 , and n X is a conventional cephalosporin substituent. n Many of the intermediates are new, especially in pure Z-form.