CAS: 36178-05-9; 3-Bromo-2-Fluoropyridine

相似化合物

473596-07-5 80392-79-6 1227502-60-4

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CAS号372-48-5 2-氟吡啶 | CAS号54231-33-3 3-溴-2-硝基吡啶 | CAS号626-55-1 3-溴吡啶 | CAS号75-05-8 乙腈 | CAS号372-48-5 2-氟吡啶 | CAS号100921-60-6 butyl-3 bromo-4... | CAS号100921-59-3 butyl-4 fluoro-... | CAS号57883-25-7 3-溴-2-乙氧基吡啶 | CAS号848243-23-2 2-乙氧基吡啶-3-硼酸频哪醇酯 | CAS号128071-98-7 4-溴-2-氟吡啶

2-氟吡啶置于lithium Diisopropyl Amide,溴,水体系中,用 四氢呋喃 用作溶剂,化学反应 16.0H,反应生成2-氟-3-溴吡啶
参考文献:Substituted Pyridines
标题:Substituted Pyridines
摘要:提供了一类包括新颖化合物的2,4-;2,3,4-;2,4,6-;2,3,4,5,6-取代吡啶.这些取代是通过本文披露的方法实现的,其中金属化的吡啶与亲电试剂发生反应.适当的亲电试剂包括co2,So2,二烷基碳酸酯,脲,甲酰胺,酰胺,羧酸酯,单烷基和二卤代烷基,氯,氟,溴和碘等卤素,金属盐,磺酮,磺酰基,醛,酮,酸酐,亚硝酸盐和亲电硼化合物,包括但不限于硼三烷氧化物和硼三卤化物.该发明更具体地披露了一种合成2,6-二氟吡啶-4-基硼酸的方法,包括:(1)将2,4,6-三氟吡啶与单水合肼反应,生成2,6-二氟-4-肼基吡啶,(2)将2,6-二氟-4-肼基吡啶与元素溴反应,生成4-溴-2,6-二氟吡啶,(3)将4-溴-2,6-二氟吡啶与有机锂化合物和硼酸盐在约0oc以下的温度下反应,生成2,6-二氟吡啶-4-基硼酸,其中所述过程在有机溶剂中进行.

专利信息

专利号:US-2024101516-A1
优先权日:2021-01-20
标 题:Synthesis of polyfluorinated aryl and heteroaryl carboxamides
发明人：KADUSKAR RAHUL; BORATE KAILASKUMAR; ADHAV SUYOG; THIRUNAVUKKARASU SARAVANAN; SHINDE HARISH; GOETZ ROLAND
权利人:BASF SE
摘要:The presently claimed invention relates to a process for the preparation of mono-, di-, tri-, fluoro arylamide or hetroarylamide.

专利号:CN-102898360-A
优先权日:2012-11-12
标题 :Synthesis of 3,5-Dibromo-4-fluoropyridine

专利号:US-7485725-B1
优先权日:2004-11-12
标 题:Substituted pyridines
发明人：CEFALO DUSTIN R; HENDERSON JASON I; MOKRI HOMAYOUN H
权利人:FRONTIER SCIENT INC
摘要:A class of 2,4-; 2,3,4-; 2,4,6-; 2,3,4,5,6-substituted pyridines is provided which include novel compounds. The substitutions are achieved according to methods disclosed herein in which a metallated pyridine is reacted with an electrophile. Suitable electrophiles include CO 2 , SO 2 , dialkylcarbonates, ureas, formamides, amides, carboxylic acid esters, mono- and dihaloalkyls, halogens such as chlorine, fluorine, bromine, and iodine, metallic salts, sulfones, sulfonyls, aldehydes, ketones, anhydrides, nitriles, and electrophilic boron compounds including, but not limited to, boron trialkoxides and boron trihalides. The subject invention more specifically discloses a process for the synthesis of 2,6-difluoropyridin-4-ylboronic acid which comprises: (1) reacting 2,4,6-trifluoropyridine with hydrazine monohydrate to produce 2,6-difluoro-4-hydrazinopyridine, (2) reacting the 2,6-difluoro-4-hydrazinopyridine with elemental bromine to produce 4-bromo-2,6-difluoropyridine, and (3) reacting the 4-bromo-2,6-difluoropyridine with an organolithium compound and a borate at a temperature of less than 0° C. to produce the 2,6-difluoropyridin-4-ylboronic acid, wherein said process is conducted in an organic solvent.

专利号:KR-20230134489-A
优先权日:2021-01-20
标题:Synthesis of polyfluorinated aryl and heteroaryl carboxamides

专利号:CN-116724021-A
优先权日:2021-01-20
标 题:Synthesis of polyfluorinated aryl and heteroaryl carboxamides

专利号:US-7087755-B1
优先权日:2004-11-12
标 题 :Substituted pyridines
发明人：CEFALO DUSTIN R; HENDERSON JASON I; MOKRI HOMAYOUN H
权利人:FRONTIER SCIENT INC
摘要:A class of 2,4-; 2,3,4-; 2,4,6-; 2,3,4,5,6-substituted pyridines is provided which include novel compounds. The substitutions are achieved according to methods disclosed herein in which a metallated pyridine is reacted with an electrophile. Suitable electrophiles include CO 2 , SO 2 , dialkylcarbonates, ureas, formamides, amides, carboxylic acid esters, mono- and dihaloalkyls, halogens such as chlorine, fluorine, bromine, and iodine, metallic salts, sulfones, sulfonyls, aldehydes, ketones, anhydrides, nitrites, and electrophilic boron compounds including, but not limited to, boron trialkoxides and boron trihalides. The subject invention more specifically discloses a process for the synthesis of 2,6-difluoropyridin-4-ylboronic acid which comprises: (1) reacting 2,4,6-trifluoropyridine with hydrazine monohydrate to produce 2,6-difluoro-4-hydrazinopyridine, (2) reacting the 2,6-difluoro-4-hydrazinopyridine with elemental bromine to produce 4-bromo-2,6-difluoropyridine, and (3) reacting the 4-bromo-2,6-difluoropyridine with an organolithium compound and a borate at a temperature of less than about 0° C. to produce the 2,6-difluoropyridin-4-ylboronic acid, wherein said process is conducted in an organic solvent.