CAS: 368-71-8; 4-(Trifluoromethyl)Benzene-1,2-Diamine

上下游产品

CAS号400-98-6 2-硝基-4-三氟甲基苯胺 | CAS号402-14-2 3-氨基-4-硝基三氟甲苯 | CAS号7732-18-5 水 | CAS号3663-35-2 4-乙基-2-硝基苯胺 | CAS号1095824-21-7 (R)-(1-(3-(6-(三... | CAS号194423-79-5 ethyl 3-chloro-... | CAS号2078-01-5 3-硝基-5-(三氟甲基)苯-... | CAS号194423-80-8 ethyl 3-chloro-... | CAS号86604-73-1 6-(三氟甲基)-1H-1,3... | CAS号86604-86-6 2-氯-6-(三氟甲基)-1H-苯并咪唑 | CAS号133687-93-1 5-三氟甲基-1,3-二氢-苯... | CAS号102729-48-6 3-chloro-2-phen... | CAS号1548-67-0 5-(三氟甲基)-1H-苯并[... | CAS号10057-46-2 2-氨基-5-(三氟甲基)苯并咪唑

3-氨基-4-硝基三氟甲苯置于氢气体系中,用 乙醇 用作溶剂,化学反应生成3,4-二胺基苄氧基三氟化物
参考文献:苯并[ D ]咪唑衍生物的合成,血管舒张活性和降压作用
标题:苯并[ D ]咪唑衍生物的合成,血管舒张活性和降压作用
摘要:使用短合成路线合成了一系列在5位被-cf 3或-no 2取代的1 P苯并本的1 H-苯并[ D ]咪唑类似物.所有硝基衍生物均有效,并表现出浓度依赖性和部分内皮依赖性血管舒张作用,Ec 50 S <5μm.2-甲氧基-4-[5-硝基-1 H-苯并[ D ]咪唑-2-基]苯酚(化合物13)是该系列中最有效的衍生物,其ec 50值为1.81μm,E Max完整的主动脉环中离体舒张反应的抗氧化活性为91.7%,与pimobendan相比,活性提高了2.5倍.密切相关的5-Cf 3类似物(化合物8)的效价比13低19倍.使用自发性高血压大鼠(shr)在25,50和100 Mg Kg-1的剂量下评估了化合物13的抗高血压活性,显示出统计学上显着的剂量依赖性效应.
Doi:10.1016/j.Bmc.2010.04.027

专利信息

专利号:US-9951049-B2
优先权日:2014-05-15
标题 :Pyrazole linked benzimidazole conjugates and a process for preparation thereof
发明人：KAMAL AHMED; SHAIK ANVER BASHA; KUMAR GAJJELA BHARATH; REDDY VANGALA SANTHOSH
权利人:COUNCIL OF SCIENT & INDUSTRIAL RESEACH; COUNCIL SCIENT IND RES
摘要:Pyrazole linked benzimidazole conjugates and a method for synthesis of one or more compounds having a pyrazole linked benzimidazole conjugate, particularly pyrazole linked benzimidazole conjugates that are useful as potential antitumor agents against human cancer cell lines, such as leukemia, non-small cell lung cancer, colon cancer, CNS cancer, melanoma, ovarian cancer, renal cancer, prostate cancer and breast cancer. The process comprises the step of oxidative cyclization of o-phenylenediamines and 3-phenyl-1H-pyrazole-5-carbaldehydes with sodium metabisulphite in ethanol/methanol solvent system at a desired temperature for a period of time to obtain the pyrazole linked benzimidazole conjugate.

专利号:US-3935314-A
优先权日:1971-11-24
标题 :Anti-hypertensive compositions of benzimidazole derivatives
发明人：WATTS ERIC ALFRED
权利人:BEECHAM GROUP LTD
摘要:Antihypertensive pharmaceutical compositions comprising a compound of the formula (II) ##SPC1## n or pharmaceutically acceptable salts or solvates thereof wherein R 1 is nitrile or amidino; R 2 is hydrogen or lower hydrocarbon; R 3 , R 4 , R 5 and R 6 which may be the same or different, are each selected from hydrogen, halogen, nitro, trifluoromethyl, lower alkyl, lower acyl, hydroxyl, lower etherified hydroxyl or lower acylated hydroxyl; together with a pharmaceutically acceptable carrier. The compounds of formula (II) are also useful as intermediates in the synthesis of the corresponding 2-aminoimidazoline compounds.

专利号:US-12304912-B2
优先权日:2020-07-28
标 题 :Fused bicyclic RAF inhibitors and methods for use thereof
发明人：BELFIELD ANDREW; JONES CLIFFORD DAVID; MARGATHE JEAN-FRANÇOIS; COLLETTO CHIARA
权利人:JAZZ PHARMACEUTICALS IRELAND LTD
摘要:The present disclosure generally relates to improved synthesis of fused bicyclic Raf inhibitors of formula (I), (I-A), (I-B), (II), or (III), or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof. The disclosure also relates to method of using the compound of formula (I), (I-A), (I-B), (II), or (III), or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, for treating diseases such as cancer, including colorectal cancer.

专利号:CN-103073598-A
优先权日:2012-10-12
标题 :Synthesis of Mono(Multi)nuclear Complexes of Wallenschiff Base and Bismuth

专利号:CA-2693182-A1
优先权日:2007-06-29
标 题:Pyrimidine compounds, methods of synthesis thereof, and use thereof in the treatment of raf kinase-mediated disorders

专利号:CN-109251529-A
优先权日:2018-08-07
标题 :A kind of multi-layer nano graphite sheet hybrid transparent polyimide film synthesis preparation method and product