CAS: 372-18-9; 1,3-Difluorobenzene

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CAS号437-81-0 2,6-二氟苯甲醛 | CAS号348-51-6 2-氯氟苯 | CAS号385-00-2 2,6-二氟苯甲酸 | CAS号625-98-9 间氯氟苯 | CAS号461-96-1 1-溴-3,5-二氟苯 | CAS号541-73-1 间二氯苯 | CAS号372-19-0 3-氟苯胺 | CAS号1435-44-5 2,4-二氟氯苯 | CAS号71-43-2 苯 | CAS号462-06-6 氟苯 | CAS号456-49-5 间氟苯甲醚 | CAS号372-20-3 3-氟苯酚 | CAS号348-57-2 2,4-二氟溴苯 | CAS号60731-73-9 2,6-二氟苯甲酰异氰酸酯 | CAS号38361-37-4 2,6-二氟氯苯 | CAS号455-40-3 3,5-二氟苯甲酸 | CAS号5509-65-9 2,6-二氟苯胺 | CAS号367-27-1 2,4-二氟苯酚 | CAS号37847-52-2 2,4-二氟联苯 | CAS号2285-29-2 1,3-difluoro-2-...

间苯二胺置于氟化氢吡啶,Sodium Nitrite体系中,用78%的收率获得1,3-二氟苯
参考文献:氟化氢与碱结合,通过氨基芳烃的脱氨基氟化,轻松制备芳族氟化物
标题:氟化氢与碱结合,通过氨基芳烃的脱氨基氟化,轻松制备芳族氟化物
摘要:通过将氟化氢与碱溶液结合使用,成功地实现了包括杂芳族化合物在内的氨基芳烃的一锅式脱氨氟化,即氨基芳烃的重氮化,然后将相应的重氮离子进行原位氟脱氮,以高产率生产了氟芳烃.已发现重氮化阶段在有效生产氟代芳烃中起着最重要的作用.它受到hf溶液组成的极大影响,并通过在谨慎控制的条件下使用适量的碱(例如吡啶)来增强.光化学方法有效地促进了氟脱重氮化阶段,从而以高收率提供了具有极性取代基(如羟基,硝基等)的氟代芳烃.
Doi:10.1016/0040-4020(95)00867-8

专利信息

专利号:WO-2020248278-A1
优先权日:2019-06-14
标题:Method for continuous synthesis of substituted benzoic-acid organic substance
发明人：HONG HAO; ZHANG ENXUAN; LU JIANGPING; LIU ZHIQING; LI CHAO; TANG YANG
权利人:JINLIN ASYMCHEM LABORATORIES CO LTD
摘要:The present invention provides a method for the continuous synthesis of a substituted benzoic-acid organic substance. The continuous synthesis method comprises: in the presence of catalyst and organic solvent, the organic matter represented by formula (I) and oxygen are continuously inputted to a continuous reaction apparatus for continuous oxidation reaction to obtain a substituted benzoic-acid organic substance, which is discharged continuously, the substituted benzoic-acid organic substance having the structure represented by formula (II). Oxygen is a green reagent and is inexpensive and readily available; a large amount of wastewater, waste gas, and solid waste is not generated after the reaction, and the system is easy to handle. The use of a continuous reaction operation can reduce the risk of flash distillation and explosion of solvent due to a high concentration of oxygen in a batch reaction. Under the same oxidation conditions, the continuous preparation process can reduce the escape of oxygen, greatly increasing the oxygen utilization rate and also simplifying the operation, improving the safety of the reaction and the yield of the substituted benzoic-acid organic substance.

专利号:US-2010016607-A1
优先权日:2006-12-11
标题:Process for the Synthesis of Highly Active Binary Metal Fluoride as a Fluorinating Agent for Aromatics
发明人：DOLBIER JR WILLIAM R; JANMANCHI KRISHNA MURTHY
权利人:UNIV FLORIDA
摘要:The subject invention relates to a process for the synthesis of highly active binary metal fluoride system for the fluorination of aromatic compounds. Fluorinated aromatic compounds are valuable synthons for the chemical synthesis of pharmaceutical drugs and novel polymers. Fluorobenzene is used to control carbon content in steel manufacturing, is an intermediate for pharmaceuticals, pesticides and other organic compounds. Fluorobenzene is typically produced by the reaction of aniline and sodium nitrite in the presence of hydrogen fluoride. The present invention relates to a process for the synthesis of highly active binary metal fluoride system consists of copper (II) fluoride and aluminum (III) fluoride for the fluorination of aromatic compounds in gas phase and recycling of the reagent, in situ, using O 2 and HF.

专利号:US-5512701-A
优先权日:1995-06-07
标题:Process for the synthesis of vinyl sulfenic acid derivatives
发明人：HOARD DAVID W; LUKE WAYNE D
权利人:LILLY CO ELI
摘要:The present invention is directed to a new process for the synthesis of vinyl sulfenic acid derivatives. These compounds are useful for the synthesis of benzo[b]thiophenes, in particular 2-aryl-benzo[b]thiophenes.

专利号:US-7759492-B2
优先权日:2004-08-20
标 题:Enantioselective synthesis of 13-oxotricyclo[8.2.1.0.3,8] trideca-3(8),4,6-triene-5-carboxylates
发明人：KEEN STEPHEN PHILIP; OLIVER STEVEN FRASER; STEWART GAVIN WILLIAM
权利人:MERCK SHARP & DOHME
摘要:An enantioselective route to compounds of formula I is disclosed: n n n n n n n n n n The compounds of formula I are key intermediates in the synthesis of compounds useful in treatment of Alzheimer's disease.

专利号:US-2023212204-A1
优先权日:2020-01-16
标题:Reagents and their use for modular enantiodivergent synthesis of c-p bonds
发明人：XU DONGMIN; RIVAS-BASCÓN NAZARET; KNOUSE KYLE W; PADIAL NATALIA; ZHENG BIN; VANTOUROUT JULIEN; SCHMIDT MICHAEL; EASTGATE MARTIN D; BARAN PHI
权利人:BRISTOL MYERS SQUIBB CO; SCRIPPS RESEARCH INST
摘要:The disclosure describes chiral P(V)-based reagents and their uses for the modular, scalable, and stereospecific synthesis of chiral phosphines, phosphine oxides and particular oligonucleotides.

专利号:US-6372945-B1
优先权日:1995-06-07
标 题 :Process for the synthesis of vinyl sulfoxides
发明人：AIKINS JAMES A; MILLER RANDAL SCOT; ZHANG TONY Y
权利人:LILLY CO ELI
摘要:The present invention is directed to a new process for the synthesis of vinyl sulfoxides, in particular diarylvinyl sulfoxides