2-(2-甲氧基苯氧基)乙醇置于正丁基锂,二苯基膦酸锂体系中,用 四氢呋喃 作为反应溶剂,化学反应 3.0H,以45%的收率获得产物2-(2-羟基乙氧基)苯酚 参考文献:Strijdonck,Gino P. F. Van; Haare,John A. E. H. Van; Hoenen,Paulus J.M.,Journal Of The Chemical Society,Dalton Transactions,1997,P. 449-462 标题:Strijdonck,Gino P. F. Van; Haare,John A. E. H. Van; Hoenen,Paulus J.M.,Journal Of The Chemical Society,Dalton Transactions,1997,P. 449-462
专利号:WO-2011101864-A1 优先权日:2010-02-17 标题 :Novel process for the synthesis of phenoxyethyl derivatives 发明人:JAIN RAJESH; JAGDEESHWAR RAO R; MAHENDER RAO SIRIPRAGADA 权利人:PANACEA BIOTEC LTD; JAIN RAJESH; JAGDEESHWAR RAO R; MAHENDER RAO SIRIPRAGADA 摘要:The present invention provides an improved process for the synthesis of 2-[2- (2,2,2-trifluoroethoxy)phenoxy]ethanol intermediate, its derivatives and/or its pharmaceutically acceptable salts, useful in the synthesis of α-1 adrenoceptor blockers such as silodosin.
专利号:EP-1734036-B1 优先权日:2005-06-14 标 题:Process for preparation of tamsulosin and its derivatives 发明人:JIH RU HWU; MAGENDRAN BALAACHARY; CHAKRABORTY SUBHASISH K; DAS ASISH R; TSAY SHWU CHEN; SHEU KUEN WANG; SHU CHUN MEI; LU CHIN KUN; CHANG WEI MIN 权利人:WELL BEING BIOCHEMICAL CORP; TAIWAN BIOTECH CO LTD 摘要:The present invention discloses a new process for the synthesis of tamsulosin derivatives of formula 1 (where R 1 and R 2 represent C 1 -C 4 alkyl groups) and their hydrochlorides and other pharmaceutically acceptable salts, comprising reacting the hydrochloride of sulphonamide 2 (where R represents C 1 -C 4 alkyl) with the ether compound 21 (where R' represents C 1 -C 4 alkyl and R' represents MeC 6 H 4 SO 2 or MeSO 2 ).
专利号:US-2003149260-A1 优先权日:1998-07-08 标 题:Process for the synthesis of oligomeric compounds
专利号:US-6399756-B1 优先权日:1998-07-08 标 题:Process for the synthesis of oligomeric compounds
专利号:WO-0002896-A1 优先权日:1998-07-08 标题 :Improved process for the synthesis of oligonucleotides and analogues thereof
专利号:US-6677471-B2 优先权日:1998-07-08 标 题:Intermediates for the synthesis of oligonucleotide analogues 发明人:CHERUVALLATH ZACHARIA S; RAVIKUMAR VASULINGA T; COLE DOUGLAS L 权利人:ISIS PHARMACEUTICALS INC 摘要:Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. Also provided are synthetic intermediates useful in such processes.
参考标题:Revisiting Hydroxyalkylation Of Phenols With Cyclic Carbonates 作者:Shih‐chieh Kao,Yi‐ching Lin,Ilhyong Ryu,Yen‐ku Wu |发布日期:2019.8.5 摘要:Fluoride‐mediated Hydroxyalkylation Reaction Of Phenols With Cyclic Carbonates. This Operationally Simple Method Enables The Synthesis Of A Variety Of Aryl β‐hydroxyethyl Ethers In Good To Excellent Yields With A Very Small Amount Of Catalyst Loading (0.1-1 Mol%). Of Particular Note Is The Efficient Conversion Of Aromatic Diols And Phloroglucinol To The Corresponding Bis‐ And Tris‐hydroxyethylated Products. To Further
合成参考文献
参考文献:10.1055/s-0037-1611710 摘要:Musolino M, Aricò F. Benzo-Fused 1,4-Heterocycles via Dialkyl Carbonate Chemistry. Synthesis. 2019 Feb 18;51(08):1770–8. doi: 10.1055/s-0037-1611710.