CAS: 52059-53-7; 2-(3-Fluorophenyl)Ethanol

上下游产品

(3-fluorophenyl)acetic acid 3-fluorostyrene oxirane 3-fluorobromobenzene 1-(2-bromoethyl)-3-fluorobenzene 2-(3-fluorophenyl)ethyl 4-methylbenzenesulfonate [2-(3-fluorophenyl)ethoxy]triisopropylsilane 2-fluoro-4-(2-hydroxyethyl)benzoic acid

甲基3-氟苯酚乙酯置于lithium Aluminium Tetrahydride体系中,用 四氢呋喃 作为反应溶剂,化学反应 4.5H,以92%的收率获得产物3-氟苯乙醇
参考文献:3,4-二氢-1 H-螺(萘-2,2'-哌啶)-1-酮作为钾竞争性酸阻滞剂的发现,合成及构效关系
标题:3,4-二氢-1 H-螺(萘-2,2'-哌啶)-1-酮作为钾竞争性酸阻滞剂的发现,合成及构效关系
摘要:为了发现一种比现有质子泵抑制剂更有效的胃分泌药,新型3,4-二氢-1 H-螺(萘-2,2'-哌啶)-1-酮衍生物可能占据两个重要的位置基于对接模型设计了h +,K +-Atpase的亲脂性口袋(称为lp-1和lp-2),它可以与k +-结合位点牢固结合.在合成的化合物中,化合物4D在大鼠中显示出强大的h +,K +-Atpase抑制活性和高胃浓度,从而对组胺刺激的大鼠胃酸分泌产生有效的抑制作用.此外,4D对大鼠的组胺刺激的胃酸分泌具有显着的抑制作用,给药后起效迅速,作用持续时间适中.这些发现可能会导致对钾竞争性酸阻滞剂药物设计的新见解.
DOI:10.1016/j.Bmc.2017.05.012

专利信息

专利号:US-6852752-B2
优先权日:1999-12-17
标 题:Urea compounds, compositions and methods of use and preparation
发明人：JACOBS JEFFREY W; PATEL DINESH; LEWIS JASON; NI ZHI-JIE
权利人:VICURON PHARM INC
摘要:Novel hydroxamic acid compounds are disclosed. These hydroxamates inhibit peptide deformylase (PDF), an enzyme present in prokaryotes and are therefore useful as antimicrobials and antibiotics. Methods of synthesis and of use of the compounds are also disclosed.

专利号:US-2005240034-A1
优先权日:2002-05-07
标 题 :Artemisinin-based peroxide compounds as broad spectrum anti-infective agents
发明人：AVERY MITCHELL; MURALEEDHARAN KANNOTH M
权利人:AVERY MITCHELL; MURALEEDHARAN KANNOTH M
摘要:Described herein is the synthesis, bioassay results and utility of new C- 9 and C- 10 substituted artemisinin derivatives with easily functionalizable groups attached to the artemisinin skeleton through carbon chain or heteroatoms. Described also is the demonstration of this class of compounds for their broad-spectrum anti-parasitic activity. Certain of these analogs possess noticeable cytotoxicity deliberately focused on treatment of cancerous diseases.