专利号:US-2008207950-A1 优先权日:2004-12-22 标 题:Enantioselective Synthesis of a Sterically Hindered Amine 发明人:BERENS ULRICH; MALAN CHRISTOPHE; KIRNER HANS JURG 权利人:CIBA SC HOLDING AG 摘要:Compounds of the formula (I) wherein R is phenyl, or phenyl substituted by Cl, Br, C 1 -C 4 alkyl or CF 3 ; R 1 is H or methyl or ethyl; R 2 is H or methyl or acyl; R 3 is H or methyl; R′ 4 is —CH 3 or â•?CH 2 ; may be obtained in high enantiopurity by hydrogenation of a compound of the formula (II) wherein R and R 3 are as in formula (I); A is acyl; and R 4 is —CH 3 or â•?CH 2 ; in the presence of a chiral Rhodium or Ruthenium catalyst. Residues R 1 as methyl or ethyl and/or R 2 as H or methyl may subsequently be introduced without racemization by deacylation and optional alkylation.
专利号:US-2010256363-A1 优先权日:2007-07-26 标题 :SYNTHESIS OF INHIBITORS OF 11ß-HYDROXYSTEROID DEHYDROGENASE TYPE 1
专利号:US-9034761-B2 优先权日:2011-07-22 标题 :Heteroleptic (allyl)(pyrroles-2-aldiminate) metal-containing precursors, their synthesis and vapor deposition thereof to deposit metal-containing films 发明人:LANSALOT-MATRAS CLÉMENT; KOROLEV ANDREY V 权利人:LANSALOT-MATRAS CLÉMENT; KOROLEV ANDREY V; L AIR LIQUIDE SOCIÉTÉANONYME POUR L ETUDE ET L EXPL DES PROCÉDÉS GEORGES CLAUDE; AIR LIQUIDE AMERICAN 摘要:Disclosed are metal-containing precursors having the formula Compound (I) wherein: —M is a metal selected from Ni, Co, Mn, Pd; and —each of R- 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , and R 10 are independently selected from H; a C1-C4 linear, branched, or cyclic alkyl group; a C1-C4 linear, branched, or cyclic alkylsilyl group (mono, bis, or tris alkyl); a C1-C4 linear, branched, or cyclic alkylamino group; or a C1-C4 linear, branched, or cyclic fluoroalkyl group. Also disclosed are methods of synthesizing and using the disclosed metal-containing precursors to deposit metal-containing films on a substrate via a vapor deposition process.
专利号:US-12365682-B2 优先权日:2022-12-19 标 题 :Process to make GLP1 RA and intermediates therefor 发明人:ALLIAN AYMAN D; BERGLUND KENNETH DEREK; COLE KEVIN PAUL; DAVIS ASHLEE JEANETTE; HESS MOLLY; JEMISON ADRIANA; KERR MARK STEVEN; MACK AUDREY GRACE; ORTIZ-MEDINA XAVIER A; REMICK DAVID MICHAEL; STARKEY DEREK ROBERT; VAID RADHE KRISHAN; YANG QIANG; KAWAGISHI FUMIKI; EMURA TAKASHI; TSUCHIYA SATOSHI; WADAMOTO MANABU; YAMAWAKI MINORU 权利人:LILLY CO ELI; CHUGAI PHARMACEUTICAL CO LTD 摘要:The present invention relates to the synthesis of 3-[(1S,2S)-1-[5-[(4S)-2,2-dimethyloxan-4-yl]-2-[(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methylindazol-5-yl)-2-oxoimidazol-1-yl ]-4-methyl-6,7-dihydro-4H-pyrazolo [4,3-c] pyridine-5-carbonyl] indol-1-yl]-2-methylcyclopropyl]-4H-1,2,4-oxadiazol-5-one, or a salt thereof, and related synthetic intermediate compounds.
专利号:EP-1828096-A2 优先权日:2004-12-22 标题:Enantioselective synthesis of a sterically hindered amine
专利号:WO-2006067060-A2 优先权日:2004-12-22 标题:Enantioselective synthesis of a sterically hindered amine