CAS: 58861-48-6; 2-(4-Fluorophenyl)Thiophene

上下游产品

thiophene boronic acid 2-bromothiophene 4-fluoroboronic acid 4-Fluorothiophenol (5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone (2-(4-fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene) 5-(4-fluorophenyl)thiophene-2-carboxylic acid 2-butyl-5-(5-(4-fluorophenyl)thiophen-2-yl)furan

对氟肉桂醛置于potassium Sulfide,碘,三乙胺,亚磷酸二乙酯,三苯基膦体系中,用 二氯甲烷,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 29.8H,反应生成 2-(4-氟苯基)噻吩
参考文献:1,3-二烯基溴化物与硒酸氰酸钾/硫化钾(ksecn / K2S)的碘催化硫属元素化合物的合成
标题:1,3-二烯基溴化物与硒酸氰酸钾/硫化钾(ksecn / K2S)的碘催化硫属元素化合物的合成
摘要:通常,可用于合成硫属元素金属的方法与苛刻条件,使用昂贵的金属,适用性广,纯化过程繁琐和收率低的缺点有关.为避免这些缺点,芳基取代的1,3-二烯基溴化物与硒氰酸钾/硫化钾(ksecn / K 2S)导致了相应的硒代苯并噻吩的开发.碘相对较温和,价格便宜并且容易获得.通过该方法已经以高收率获得了几种不同取代的硒代苯并噻吩.使用该程序2-(4-氯苯基)噻吩,一种合成黑色素浓缩激素受体配体的关键中间体,参与了饮食失调,体重增加,肥胖,抑郁和焦虑症的治疗.尽管该反应基本上是一锅的,但它分两个步骤进行,涉及硒代氰酸酯/硫醇盐中间体,从而导致硒烯/噻吩.简单的操作,使用廉价的试剂和无金属的工艺使该程序对于容易获得取代的硒代苯并噻吩具有更大的吸引力.
DOI:10.1002/adsc.201701232

专利信息

专利号:WO-2017063617-A1
优先权日:2015-10-13
标 题 :Preparation of intermediates for the synthesis of canagliflozin and dapagliflozin
发明人：ZEZULA JOSEF; BABIAK PETR; HAJDUCH JAN
权利人:ZENTIVA KS
摘要:The present invention relates to a preparation method of the intermediates of structures la (for the synthesis of canagliflozin) and 1b (for the synthesis of dapagliflozin), where in structure la X is methyl and Ar represents 2-(5-(4-fluorophenyl)-thienyl) and in structure 1b X is chlorine and Ar represents 4-ethoxyphenyl.

专利号:EP-2918579-A1
优先权日:2014-03-14
标题 :Synthesis of 2-arylmethyl-5-aryl-thiophene
权利人:LEK PHARMACEUTICALS
摘要:The present invention provides a new synthetic process for the production of 2-arylmethyl-5-aryl-thiophene, an intermediate in the synthesis of C-aryl glycosides.

专利号:US-2017247359-A1
优先权日:2014-09-05
标题 :Process for the preparation of canagliflozin
发明人：VELLANKI SIVA RAM PRASAD; BALUSU RAJA BABU; PILLI RAMAKRISHNA; JAWAJI RAJESWARA ROA; ANNADASU ANKAMA NAYUDU
权利人:MYLAN LABORATORIES LTD
摘要:A process for the preparation of canagliflozin. The process may be effectively implemented on an industrial scale. Several compounds useful as intermediates for the synthesis of canagliflozin (Formula 4, Formula 4a, Formula 4b and Formula 5) are also disclosed. The process involves the reduction of the compound of formula 3 in the presence of a metal hydride and an organic solvent to obtain the compound of formula 4, converting this into a compound of formula 5 which in turn is converted into canagliflozin.

专利号:WO-9321213-A1
优先权日:1992-04-16
标题 :Alpha-aminoboronic acid peptides and their use as elastase inhibitors
发明人：BERNSTEIN PETER ROBERT; SHAW ANDREW; SHENVI ASHOKKUMAR BHIKKAPPA; THOMAS ROYSTON MARTIN; WARNER PETER; WOLANIN DONALD JOHN
权利人:ZENECA LTD
摘要:The present invention relates to certain novel heterocyclic derivatives which are 1-pyridylacetamide derivatives of formula (I), set out herein, which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases on mammals in which (HLE) is implicated. The invention also includes intermediates useful in the synthesis of these heterocyclic derivatives, processes for preparing the heterocyclic derivatives, pharmaceutical compositions containing such heterocyclic derivatives and methods for their use.

专利号:CN-115260151-A
优先权日:2022-09-02
标 题:Synthesis process of canagliflozin impurity

专利号:CN-109402659-B
优先权日:2018-12-28
标 题 :Green synthesis method of alpha-thioenamine compound