CAS: 114393-97-4; 4-(2-(5-Ethylpyridin-2-yl)Ethoxy)Benzaldehyde

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1333112-55-2 868754-42-1 1229114-66-2

上下游产品

5-ethyl-2-(2-hydroxyethyl)pyridine 4-hydroxy-benzaldehyde 4-[2-(5-ethylpyridin-2-yl)ethoxy] benzonitrile 2-(5-ethyl-pyridin-2-yl)ethyl methanesulfonate Nicotinic acid [1-{4-[2-(5-ethyl-pyridin-2-yl)-ethoxy]-phenyl}-meth-(E)-ylidene]-hydrazide Isonicotinic acid [1-{4-[2-(5-ethyl-pyridin-2-yl)-ethoxy]-phenyl}-meth-(E)-ylidene]-hydrazide 2-Methyl-benzoic acid [1-{4-[2-(5-ethyl-pyridin-2-yl)-ethoxy]-phenyl}-meth-(E)-ylidene]-hydrazide Benzoic acid [1-{4-[2-(5-ethyl-pyridin-2-yl)-ethoxy]-phenyl}-meth-(E)-ylidene]-hydrazide

4-[2-(5-Ethyl-2-Pyridinyl)Ethoxy]Benzaldehyde Oxalate置于水,Potassium Carbonate体系中,用 乙酸乙酯 用作溶剂,化学反应生成4-[2-(5-乙基-2-吡啶基)乙氧基]苯甲醛
参考文献: Process For The Synthesis Of Pioglitazone Hydrogen Chloride[fr] Procede De Synthese De Chlorure D'Hydrogene De Pioglitazone
标题: Process For The Synthesis Of Pioglitazone Hydrogen Chloride[fr] Procede De Synthese De Chlorure D'Hydrogene De Pioglitazone
摘要:该发明涉及一种合成吡格列酮盐酸盐的过程-这是一种抗糖尿病药物-通过用碱与4-[2-(5-乙基-2-吡啶基)-乙氧基]-苯甲醛盐(式(II))的hx反应,其中hx为:Hcl,Cf3Cooh,C4H4O4,(cooh)2,然后与噻唑烷-2,4-二酮反应,得到5-[[4-[2-(5-乙基-2-吡啶基)乙氧基]苯基]亚甲基]-2,4-噻唑烷二酮碱,然后用盐酸处理,得到5-[[4-[2-(5-乙基-2-吡啶基)乙氧基]苯基]亚甲基]-2,4-噻唑烷二酮盐酸盐(式(III)),在催化剂存在下,对其进行氢化.该发明的进一步对象是通式(II)的盐和通式(III)的苄亚甲基衍生物.

专利信息

专利号:WO-2009148195-A1
优先权日:2008-06-02
标题:5-(4-hydroxybenzyl)thiazolidine-2,4-dione as intermediate for synthesis of thiazolidinedione based compounds and process for preparing the same
发明人：PARK JIN OH; KIM YONG GIL; SON HAN IL; LEE YUN JEONG; KIM EUN MI
权利人:DAEBONG LS LTD; PARK JIN OH; KIM YONG GIL; SON HAN IL; LEE YUN JEONG; KIM EUN MI
摘要:The present invention relates to 5-(4-hydroxybenzyl)thiazolidine-2,4-dione represented by the following Chemical Formula [1], which is useful as an intermediate for synthesis of thiazolidinedione based compounds, a method for preparing the compound, and a method for preparing pioglitazone or pioglitazone hydrochloride, which is a thiazolidinedione based drug and useful in treating and preventing diabetes, using the 5-(4-hydroxybenzyl)thiazolidine-2,4-dione represented by Chemical Formula [1] as an intermediate:

专利号:EP-1694646-B1
优先权日:2003-12-19
标题 :Process for the synthesis of pioglitazone hydrogen chloride
发明人：FISCHER JANOS; FODOR TAMAS; LEVAI SANDOR; PETENYI ENDRENE; PERENYI EVA
权利人:RICHTER GEDEON VEGYESZET
摘要:The invention relates to a process for the synthesis of pioglitazone hydrogen chloride - which is an antidiabetic drug - via novel intermediates by reacting 4-[2-(5-ethyl-2-pyridinyl)-ethoxy]-benzaldehyde salt of formula (II), wherein HX is: HCI, CF3COOH, C4H4O4, (COOH)2 with a base and then thiazolidine-2,4-dione, and the obtained 5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methylene]-2,4-thiazolidinedione base is treated with hydrochloric acid and the obtained 5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl] methylene]-2,4-tiazolidinedione hydrogen chloride of formula(III) is hydrogenated in the presence of a catalyst. Further objects of the invention are the salts of general formula (II) and the benzylidene derivative of formula (III).

专利号:EP-1694646-A1
优先权日:2003-12-19
标题 :Process for the synthesis of pioglitazone hydrogen chloride

专利号:ES-2286712-T3
优先权日:2003-12-19
标 题 :PROCESS FOR THE SYNTHESIS OF HYDRO-CHLORIDE OF PIOGLITAZONA.

专利号:CN-116496207-A
优先权日:2023-04-23
标题:Method for green synthesis of 4- [2- (5-ethyl-2-pyridyl) ethoxy ] benzaldehyde

专利号:WO-2005058827-A1
优先权日:2003-12-19
标 题 :Process for the synthesis of pioglitazone hydrogen chloride