CAS: 121-25-5; 1-((4-Amino-2-Propylpyrimidin-5-yl)Methyl)-2-Methylpyridin-1-Ium Chloride

专利信息

专利号:US-8252927-B2
优先权日:2008-07-22
标题:Synthesis of substituted 4-amino-pyrimidines
发明人：KARGE REINHARD; LETINOIS ULLA; SHIEFER GERHARD
权利人:KARGE REINHARD; LETINOIS ULLA; SHIEFER GERHARD; DSM IP ASSETS BV
摘要:The present invention is directed to a process for the manufacture of compounds of formula IV wherein R 1 is an amino protecting group, and R 2 is hydrogen or C 1-10 alkyl, comprising a) reacting a compound of formula Ia, wherein M + is a cation, preferably selected from the group consisting of Li + , Na+, K + , ½ Mg 2+ and ½ Zn 2+ , (formula 1 a ) with an ammonium salt NH 4 + X − , wherein X − is an anion, preferably selected from the group consisting of chloride, bromide, sulfate and acetate, in a solvent to a compound of formula II b) reacting a compound of formula II with a nitrile R 2 —CN in the presence of a base to a compound of formula IV. The present invention is further directed to compounds of formula II and their use for the manufacture of vitamin B 1 .

专利号:US-8198443-B2
优先权日:2007-01-19
标题 :Synthesis of 4-amino-pyrimidines scaffolds
发明人：BONRATH WERNER; HAERTER RALPH; KARGE REINHARD; LETINOIS ULLA
权利人:BONRATH WERNER; HAERTER RALPH; KARGE REINHARD; LETINOIS ULLA; DSM IP ASSETS BV
摘要:Process for the manufacture of a compound of the structure (I) with R1=hydrogen, alkyl (C1-C10, linear, cyclic or branched, aliphatic or aromatic), NR′R″ (wherein R′ and R″ are independently selected from H, alkyl [C1-C10, linear, cyclic or branched, aliphatic or aromatic] and R2=CH2R3 wherein R3 is selected from NHR1′″ (with R′″=C(O)H, C(O)CH3, C(O)alkyl, CH2C6H2(OMe)3 or other saponifiable residues), alkyl (C1-C10, linear, cyclic or branched) aromatic residues, heteroaryl residues, substituted aryl residues, e.g. 3,4,5-trimethoxy-phenyl) wherein 1 equivalent of an α-formyl-propionitrile salt is reacted with 0.75 to 2 equivalents of an acetamidine salt in the presence of a Lewis acid.

专利号:US-5583081-A
优先权日:1993-08-31
标 题 :Copper-containing zeolite catalysts
发明人：PRICE GEOFFREY L; KANAZIREV VLADISLAV
权利人:UNIV LOUISIANA STATE; BULGARIAN ACADEMY OF SCIENCES
摘要:A catalyst useful in the conversion of nitrogen oxides or in the synthesis of nitriles or imines from amines, formed by preparing an intimate mechanical mixture of a copper (II)-containing species, such as CuO or CuCl 2 , or elemental copper, with a zeolite having a pore mouth comprising 10 oxygen atoms, such as ZSM-5, converting the elemental copper or copper (II) to copper (I), and driving the copper (I) into the zeolite.

专利号:EP-2102172-B1
优先权日:2007-01-19
标 题:Synthesis of 4-amino-pyrimidines

专利号:KR-101675604-B1
优先权日:2008-07-22
标题 :Novel synthesis of substituted 4-amino-pyrimidines

专利号:EP-1972620-A1
优先权日:2007-01-19
标题:Synthesis of 4-amino-pyrimidines