CAS: 13223-25-1; 2-Chloro-4,6-Dimethoxypyrimidine

相似化合物

22536-63-6 83774-09-8 5270-94-0

上下游产品

CAS号106615-46-7 4,6-二甲氧基-2-(1-哌嗪)嘧啶 | CAS号110284-90-7 methyl 2-(4,6-d... | CAS号110284-76-9 2-(4,6-dimethox... | CAS号128276-49-3 4,6-二甲氧基嘧啶-2-羧酸乙酯 | CAS号5270-94-0 4,6-二甲氧基嘧啶 | CAS号90905-46-7 4,6-二甲氧基-2-甲硫基嘧啶 | CAS号57235-35-5 4,6-二甲氧基-2-巯基嘧啶 | CAS号13223-43-3 2-氨基-5,7-二甲氧基-1... | CAS号113583-35-0 4,6-二甲氧基-2-甲磺酰基嘧啶 | CAS号135186-78-6 环酯草醚

[(E)-3-氨基-1,3-二甲氧基丙-2-烯亚基]氰胺置于盐酸体系中,用 甲醇 用作溶剂,化学反应 2.0H,以82.1%的收率获得2-氯-4,6-二甲氧基嘧啶
参考文献:2-氯-4,6-二甲氧基嘧啶的合成方法
标题:2-氯-4,6-二甲氧基嘧啶的合成方法
摘要:本发明提供了一种2‑氯‑4,6‑二甲氧基嘧啶的合成方法,属于有机合成技术领域.一种以丙二腈,甲醇,乙酰氯,单氰胺,碱液原料的合成路线,将乙酰氯滴加至丙二腈与甲醇体系中,直接得到1,3‐二甲基丙二脒二盐酸盐,后与碳酸氢钠,单氰胺反应得到3‑氨基‑3‑甲氧基‑n‑腈基‑2‑丙脒,进一步与氯化氢反应得到2‑氯‑4,6‑二甲氧基嘧啶.本发明的合成方法节省了1,3‐二甲基丙二脒二盐酸盐繁琐的合成工艺及设备,将乙酰氯加入到丙二腈与甲醇中,一步法直接得到1,3‐二甲基丙二脒二盐酸盐.本发明中1,3‐二甲基丙二脒二盐酸盐合成路线水分控制极低,产品质量稳定,收率高.

专利信息

专利号:US-2023399302-A1
优先权日:2020-10-29
标题:Process for the preparation of heteroaryl-substituted sulfur(vi) compounds
发明人：LOPCHUK JUSTIN M; SHULTZ ZACHARY P; SCATTOLIN THOMAS
权利人:H LEE MOFFITT CANCER CT & RES
摘要:The present disclosure provides processes for the synthesis of organic compounds, in particular processes for the synthesis of heteroaryl-substituted sulfur(VI) compounds by nucleophilic aromatic substitution.

专利号:RU-2117007-C1
优先权日:1991-11-26
标 题:Method of synthesis of 2-substituted 4,6-dialkoxypyrimidines, 2-n-butylamino-4,6-dimethoxypyrimidine and a method of synthesis of halogen-derivative of pyrimidine

专利号:US-11794180-B2
优先权日:2015-10-29
标 题 :Tri-(adamantyl)phosphines and applications thereof
发明人：CARROW BRAD P; CHEN LIYE
权利人:UNIV PRINCETON
摘要:In one aspect, phosphine compounds comprising three adamantyl moieties (PAd3) and associated synthetic routes are described herein. Each adamantyl moiety may be the same or different. For example, each adamantyl moiety (Ad) attached to the phosphorus atom can be independently selected from the group consisting of adamantane, diamantane, triamantane and derivatives thereof. Transition metal complexes comprising PAd3 ligands are also provided for catalytic synthesis including catalytic cross-coupling reactions.

专利号:CN-107759528-B
优先权日:2017-11-08
标 题 :Synthesis method of 2-chloro-4, 6-dimethoxypyrimidine

专利号:CN-116143657-B
优先权日:2022-11-25
标 题:Synthesis method of malononitrile