CAS: 13816-33-6; 4-Isopropylbenzonitrile

该化合物是一种有机化合物,其特征是用硝酸基组(-CN)和异丙基(-C(CH))取代苯环,其位置为第1段,该化合物一般是无色的,可粉黄黄色液体或固体,视其体温的状态而定,视其芳香特性而定,并经常用于有机合成和生产各种化学品的中间体.硝酸盐组的存在有助于其再活性,使其在核生殖反应中有用.此外,该异丙基组影响其溶性性和沸点,通常使其更具水性.安全数据表明,应谨慎处理该化合物,因为它在接触时可能会对健康造成危害.

结构式图片

相似化合物

122-03-2 536-66-3 4210-32-6

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CAS号122-03-2 枯名醛 | CAS号3717-17-7 Benzaldehyde, 4... | CAS号536-60-7 4-异丙基苯甲醇 | CAS号58324-82-6 4-(2-nitropropa... | CAS号99-87-6 4-异丙基甲苯 | CAS号623-03-0 对氯苯腈 | CAS号77047-87-1 2-丙基溴化锌 | CAS号61946-90-5 N-hydroxy-4-pro... | CAS号5458-26-4 1,3-Dioxolane,2... | CAS号536-66-3 4-异丙基苯甲酸 | CAS号4395-73-7 4-异丙基苯甲胺 | CAS号53515-20-1 4-异丙基苯硫代羧胺 | CAS号19956-03-7 4-prop-1-en-2-y... | CAS号77802-22-3 4-(2-hydroxypro... | CAS号888028-33-9 1-[4-(1-甲基乙基)苯基]-环丙胺 | CAS号619-76-1 4-异丙基苯甲酰胺

合成工艺路线路线简述

    4-异丙基苯甲酸置于sodium Metabisulfite,三氯氧磷体系中,化学反应生成4-异丙基苯甲腈
    参考文献:The Electronic Properties Of Alkyl Groups. Ii. The Dipole Moments Of Alkyl Benzenes And Derivatives
    标题:The Electronic Properties Of Alkyl Groups. Ii. The Dipole Moments Of Alkyl Benzenes And Derivatives
    摘要:
    Doi:10.1021/ja01522A018

    海关参考信息

    专利信息


    专利号:US-8106031-B2
    优先权日:2006-05-02
    标题:Hydrolytically-resistant boron-containing therapeutics and methods of use
    发明人:LEE VING; PLATTNER JACOB J; BENKOVIC STEPHEN J; BAKER STEPHEN J; MAPLES KIRK R; BELLINGER-KAWAHARA CAROLYN; AKAMA TSUTOMU; ZHANG YONG-KANG; SINGH RAJESHWAR; SAURO VITTORIO A
    权利人:LEE VING; PLATTNER JACOB J; BENKOVIC STEPHEN J; BAKER STEPHEN J; MAPLES KIRK R; BELLINGER-KAWAHARA CAROLYN; AKAMA TSUTOMU; ZHANG YONG-KANG; SINGH RAJESHWAR; SAURO VITTORIO A; ANACOR PHARMACEUTICALS INC
    摘要:Compositions and methods of use of boron derivatives, including benzoxaboroles, benzazaboroles and benzthiaboroles, as therapeutic agents for treatment of diseases caused by fungi, yeast, bacteria or viruses are disclosed, as well as methods for synthesis of said agents and compositions thereof.

    专利号:US-8129520-B2
    优先权日:2003-06-06
    标题 :Methods and intermediates for the synthesis of dipyrrin-substituted porphyrinic macrocycles
    发明人:YU LIANHE; MUTHUKUMARAN KANNAN; SREEDHARAN PRATHAPAN; LINDSEY JONATHAN S
    权利人:YU LIANHE; MUTHUKUMARAN KANNAN; SREEDHARAN PRATHAPAN; LINDSEY JONATHAN S; UNIV NORTH CAROLINA STATE
    摘要:The present invention provides dipyrrin substituted porphyrinic macrocycles, intermediates useful for making the same, and methods of making the same. Such compounds may be used for purposes including the making of molecular memory devices, solar cells and light harvesting arrays.

    专利号:US-4536599-A
    优先权日:1978-08-22
    标题:Synthesis of amine derivatives
    发明人:MASUKO FUJIO; KATSURA TADASHI
    权利人:SUMITOMO CHEMICAL CO
    摘要:An amine of the formula, ##STR1## wherein R 1 , R 2 , R 3 , R 4 and R 5 are each hydrogen, alkyl or the like and n is 1, 2 or 3, including α-phenyl-β-(p-tolyl)-ethylamine, which is useful as an optically resolving agent, an intermediate of medicines and the like, is effectively produced by a novel process comprising hydrolysis of the corresponding nitrile of the formula, ##STR2## wherein R 1 , R 2 , R 3 , R 4 , R 5 and n are the same as above, followed by alkali-decomposition of the resulting amide of the formula, ##STR3## wherein R 1 , R 2 , R 3 , R 4 , R 5 and n are the same as above. An amide including the above one is effectively produced by hydrolysis of the corresponding nitrile in the presence of a base and hydrogen peroxide using an organic quaternary ammonium salt and/or a tertiary amine as a catalyst.

    专利号:WO-2021143617-A1
    优先权日:2020-01-16
    标题 :Cyclohexadiene oxime ether compound, synthesis method therefor and application thereof
    发明人:DENG ZHAOXI; Hu Hewei; GUO SHAOXIONG; CEN JIN; TAN BIN; DU BINGBING; YANG LINA; LI JUNPEI
    权利人:ZHENGZHOU INSTITUTE OF CHIRAL DRUGS RES CO LTD
    摘要:The present invention provides a cyclohexadiene oxime ether compound having the following structural formula: (I) or (II) or (III); group R 1 and group R 3 are each selected from -H, an aliphatic substituent containing 1-6 carbon atoms, a halogenated aliphatic substituent, a cyano-substituted aliphatic substituent, amino or amide, phenyl, and a halogenated aromatic substituent or a cyano-substituted aromatic substituent; group R 2 is selected from -H, an aliphatic substituent containing 1-6 carbon atoms, a halogenated aliphatic substituent, a cyano-substituted aliphatic substituent, amino or amide, phenyl, a halogenated aromatic substituent, and a cyano-substituted aromatic substituent, a nitro-substituted aromatic substituent or a heterocyclic aromatic substituent; and the heterocyclic aromatic substituent is selected from (iv), (v) or (vi), wherein X is selected from -H, halogen, -CN, -NO 2 , and -CF 3 , -C(CF 3 ) 3 , and n is the number of substituents and is selected from 1, 2, and 3. The present invention also provides a preparation method for the above-mentioned cyclohexadiene oxime ether compound and an application thereof.

    专利号:US-11858880-B2
    优先权日:2017-06-16
    标题 :Anti-fungals compounds targeting the synthesis of fungal sphingolipids

    专利号:US-11767302-B2
    优先权日:2020-10-01
    标题 :Reagents and methods for tetrazine synthesis
    发明人:FOX JOSEPH M; LAMBERT WILLIAM; FANG YINZHI; AM ENDE CHRISTOPHER WILLIAM; MAHAPATRA SUBHAM; XIE YIXIN; WANG CHUANQI
    权利人:UNIV DELAWARE
    摘要:Disclosed herein are mono- and di-substituted tetrazines and methods of their preparation and converting an oxetanyl ester to a thio-substituted tetrazine, which is then converted to a mono-substituted tetrazine, a di-substituted tetrazine, or a vinylether disubstituted tetrazine.
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    合成参考文献


    摘要:Drabowicz, J.; Krasowska, D.; Wicha, J., Science of Synthesis, (2009) 48, 259.
    摘要:Dekeukeleire, S.; D'hooghe, M.; De Kimpe, N., Science of Synthesis Knowledge Updates, (2011) 3, 138.
    摘要:Inagi, S.; Taniguchi, K.; Lam, K., Science of Synthesis: Modern Strategies in Organofluorine Chemistry, (2024) 2.
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