CAS: 139481-72-4; 2-Ethoxy-1-((2'-(1-Trityl-1H-Tetrazol-5-yl)-[1,1'-Biphenyl]-4-yl)Methyl)-1H-Benzo[d]Imidazole-7-Carboxylic Acid

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CAS号76-83-5 三苯基氯甲烷 | CAS号139481-59-7 坎地沙坦 | CAS号821-25-0 1,1-dichloroheptane | CAS号21606-04-2 2-(甲氧羰基)-6-硝基苯甲酸 | CAS号57113-90-3 2-(叔丁氧羰基氨基)-3-硝... | CAS号139481-69-9 坎地沙坦甲酯 | CAS号136304-78-4 3-氨基-2-[(2-氰基联苯... | CAS号603-11-2 3-硝基邻苯二甲酸 | CAS号139481-28-0 甲酯C4 | CAS号73833-13-3 acid chloride o... | CAS号145040-37-5 坎地沙坦酯 | CAS号170791-09-0 三苯甲基坎地沙坦西来替昔酯

坎地沙坦乙酯置于水,三乙胺,Sodium Hydroxide体系中,用 二氯甲烷 用作溶剂,化学反应 20.0H,反应生成三苯甲基坎地沙坦
参考文献:Method For Preparing Trityl Candesartan
标题:Method For Preparing Trityl Candesartan
摘要:本发明使用坎地沙坦环状化合物作为起始物质,并对其进行三步反应,包括形成四唑,水解和添加保护基,直接获得三苯甲基坎地沙坦,而无需通过结晶分离中间产物.操作过程简单,因此更适用于工业生产.

专利信息

专利号:US-2008214637-A1
优先权日:2004-11-11
标题 :Process for the Synthesis of Tetrazoles
发明人：ANTONCIC LJUBOMIR; LUDESCHER JOHANNES
权利人:LEK PHARMACEUTICALS
摘要:A process for the synthesis of tetrazol derivative has been developed which starts from a tetrazole derivative where acidic hydrogen atom has been replaced by a protecting group and the deprotection is performed with a catalytic amount of organic acid and can proceed in an aqueous solvent.

专利号:US-7098342-B2
优先权日:2003-10-16
标题 :Preparation of candesartan cilexetil
发明人：ETINGER MARINA YU; FEDOTEV BORIS; DOLITZKY BEN-ZION
权利人:TEVA PHARMA
摘要:The invention encompasses processes for the synthesis of cilexetil trityl candesartan from the reaction of trityl candesartan with cilexetil halide in the presence of a base and a low boiling organic solvent. Optionally, the reaction may be conducted in the presence of a phase transfer catalyst.

专利号:WO-2008012852-A1
优先权日:2006-07-27
标 题:Intermediate compounds for the preparation of angiotensin ii antagonists
发明人：GUANDALINI LUCA; MARTINI ELISABETTA; ROMANELLI MARIA NOVELLA; DALLATOMASINA FRANCO
权利人:S I M S S R L SOC IT MEDICINAL; GUANDALINI LUCA; MARTINI ELISABETTA; ROMANELLI MARIA NOVELLA; DALLATOMASINA FRANCO
摘要:The present invention relates to novel substituted biphenyltetrazole compounds useful as intermediates in the preparation of angiotensin II antagonists, to a process for the synthesis of them and to a process for the conversion thereof to said molecules.

专利号:US-7884212-B2
优先权日:2005-10-07
标题 :Process for the preparation of candesartan cilexetil
发明人：ZUPANCIC SILVO
权利人:ZUPANCIC SILVO
摘要:The present invention provides an improved synthesis for the manufacture of candesartan and pharmaceutically acceptable salts and esters thereof as active ingredients of a medicament for the treatment of hypertension and related diseases and conditions which comprises the removal of the tetrazolyl protecting group in an organic solvent, and in the presence of a Lewis acid.

专利号:WO-2006050922-A1
优先权日:2004-11-11
标 题:Process for the synthesis of tetrazoles

专利号:EP-1812423-A1
优先权日:2004-11-11
标 题 :Process for the synthesis of tetrazoles