专利号:US-4220774-A 优先权日:1978-10-26 标 题:Vincadifformine synthesis process 发明人:KUEHNE MARTIN E 权利人:OMNIUM CHIMIQUE SA 摘要:The preparation of vincadifformine and some derivatives thereof for use as a starting material for synthesis of the corresponding vincamine derivatives or for synthesis of bisindole alkaloids having clinically important antitumor properties.
专利号:US-12371404-B2 优先权日:2016-12-08 标 题 :Fused bicyclic alkylene linked imidodicarbonimidic diamides, methods for synthesis, and uses in therapy 发明人:BATCHELOR KENNETH; COBB JEFFERY E; GUDMUNDSSON KRISTJAN S; HENKE BRAD R; TAVARES FRANCIS X 权利人:NOVATARG INC 摘要:The present invention provides novel fused bicyclic alkylene linked imidodicarbonimidic diamides. In particular, described herein are N-[2-(indol-3-yl)alkylene]-linked imidodicarbonimidic diamides and N-[2-(pyrrolopyridin-3-yl)alkylene]-linked imidodicarbonimidic diamides (compound of formula (I) or formula (II)), and uses therefor. The compounds of the present invention are believed to be organic cation transporter selective compounds, useful for the treatment of diseases and conditions caused by reduced activity of 5′ adenosine monophosphate-activated protein kinase (AMPK).
专利号:DE-3234332-A1 优先权日:1982-09-16 标 题:TIED, STABILIZED, HIGHLY PURE STRICTOSIDINE SYNTHASE, METHOD FOR THE PRODUCTION AND USE OF THE SYNTHESIS OF 3 (ALPHA) (S) -STRICTOSIDINE
专利号:KR-102476098-B1 优先权日:2019-09-06 标题:Synthesis of crystalline tetrahydro-beta-carboline
专利号:KR-20210029514-A 优先权日:2019-09-06 标题 :Synthesis of crystalline tetrahydro-beta-carboline
专利号:US-4526991-A 优先权日:1983-10-01 标题:2,6-Dioxa-bicyclo-[2,2,2]-octane-7-yl-acetaldehydes 发明人:THIES PETER W; DAVID SAMUEL 权利人:KALI CHEMIE AG 摘要:2,6-Dioxa-bicyclo-[2,2,2]-octane-7-yl-acetaldehydes of the general Formula I, ##STR1## wherein R 1 is a benzyl or lower alkyl group, and A and B either are each hydrogen or together represent a single bond between their respective carbons, and a method for producing such compounds. The compounds are valuable intermediates in the synthesis of pharmacologically active substances having, for example, cardiovascular effects.
[参考文献]: Anna M Piasta, Et Al. New Procedure Of Selected Biogenic Amines Determination In Wine Samples By Hplc. Anal Chim Acta. 2014 Jun 27:834:58-66. [参考文献]: C Stubert, Et Al. Determinants Involved In Subtype-Specific Functions Of Rat Trace Amine-Associated Receptors 1 And 4. Br J Pharmacol. 2013 Mar;168(5):1266-78. [参考文献]: Jing Yuan, Et Al. Genetic Mapping Of Targets Mediating Differential Chemical Phenotypes In Plasmodium Falciparum. Nat Chem Biol. 2009 Oct;5(10):765-71. [参考文献]: M A Anwar, Et Al. Vasoconstrictor And Vasodilator Responses To Tryptamine Of Rat-Isolated Perfused Mesentery: Comparison With Tyramine And β-Phenylethylamine. Br J Pharmacol. 2012 Apr;165(7):2191-202. [参考文献]: Maria Notou, Et Al. Automated Derivatization And Fluorimetric Determination Of Biogenic Amines In Milk By Zone Fluidics Coupled To Liquid Chromatography. J Chromatogr A. 2014 Aug 22:1356:272-6.
合成参考文献
摘要:Japanese Journal of Medical Sciences, Part 4: Pharmacology., 2(77), 1927 参考文献:10.1007/bf02158745 摘要:Moussatché H. On the nature of some smooth muscle active substances from the platelets. Cellular and Molecular Life Sciences. 1954 Jul;10(7):309–11. doi: 10.1007/bf02158745.