CAS: 4315-07-5; 4-(Trifluoromethoxy)Phenylacetic Acid

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CAS号870637-76-6 2-diazo-4'-trif... | CAS号330-12-1 4-(三氟甲氧基)苯甲酸 | CAS号1736-74-9 4-(三氟甲氧基)苄醇 | CAS号50824-05-0 对三氟甲氧基溴苄 | CAS号587-18-8 4-(三氟甲氧基)苯甲酸乙酯 | CAS号49561-96-8 对三氟甲氧基苯乙腈 | CAS号196811-90-2 2-[4-(三氟甲氧基)苯基]乙醇 | CAS号29270-33-5 α-溴-4-氟苯乙酸 | CAS号851547-51-8 1-chloro-3-[4-(... | CAS号851547-53-0 [2-oxo-3-[4-(tr...

对溴三氟甲氧基苯置于n,O-双三甲硅基乙酰胺,10-Phenyl-9-(2,4,6-Trimethylphenyl)Acridinium Tetrafluoroborate,N,N-二异丙基乙胺,二苯二硫醚,均三甲苯体系中,用 乙二醇二甲醚 作为反应溶剂,化学反应 32.17H,反应生成 4-(三氟甲氧基)苯乙酸
参考文献:α-氯代羰基与芳基卤化物跨亲电偶联的metallaphotoredox策略.
标题:α-氯代羰基与芳基卤化物跨亲电偶联的metallaphotoredox策略.
摘要:在这里,我们证明了金属氧还原催化的亲电子交联机理为多种活化烷基氯的α-芳基化反应提供了统一的方法,包括α-氯酮,α-氯酸酯,α-氯酰胺,α-氯羧酸和苄基氯. .该策略对多种芳基溴化物偶联伙伴有效,基于卤素原子的提取/镍自由基捕获机制,该机制普遍适用于广泛的羰基底物.芳基丙烯酸产品的构建和使用进一步实现了两步协议,可用于交付药用化学的重要组成部分,例如芳基二氟甲基和二芳基甲烷图案.
DOI:10.1002/anie.201909072

专利信息

专利号:US-2025091989-A1
优先权日:2023-09-19
标 题 :Small molecule protein synthesis modulators
发明人：GYGI DAVID; BAHMANYAR SOGOLE SAMI; HAMANN LAWRENCE
权利人:INTERDICT BIO INC
摘要:The present disclosure provides compounds of the formulae herein (e.g., Formula (I)), and pharmaceutically acceptable salts thereof, which are useful for modulating protein synthesis (e.g., modulating synthesis of BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D). The present disclosure also provides pharmaceutical compositions and kits comprising the compounds, or pharmaceutically acceptable salts thereof, and methods of treating or preventing diseases or disorders (e.g., diseases or disorders associated with BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D) by administering to a subject in need thereof the compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof.

专利号:EP-3515880-B1
优先权日:2017-03-17
标题:Methods and compositions for synthesis of encoded libraries
发明人：LI JIN; MORGAN BARRY A; Wan jinqiao; DOU DENGFENG; LIU GUANSAI; CHANG YONG; CHEN QIUXIA; WANG XING; XU YANSHAN; HU DONGYAN; LIU JIAN; CHENG XUEMIN
权利人:HITGEN INC

专利号:US-2020149034-A1
优先权日:2017-03-17
标题:Methods and Compositions for Synthesis of Encoded Libraries