CAS: 520-72-9; Benzo[b]Thiophen-3-Ol

该化合物是一种有机化合物,其特征为引信环结构,其中包括一个苯环和一个硫苯环,其氢氧基(-OH)组位于硫苯环的三碳处,该组通常具有黄色至褐色的青色色,因其芳香特性而闻名,有助于其在有机合成和材料科学中的潜在应用. 本佐[b]thephene-3-ol在有机溶剂中溶解,且在水中溶解性有限,这对许多芳香化合物来说很常见.其结构允许各种化学反应,包括电子替代和与生物系统的潜在互动,使其对医药化学感兴趣.此外,该组还可能具有抗氧化性特性,并已就其在制药和农用化学品中的潜在用途进行了研究.应当参考安全数据,以便处理,如同任何化学物质一样,确保采取适当的防范措施.

结构式图片

上下游产品

CAS号3704-28-7 2-(甲硫基)苯甲酸甲酯 | CAS号130-03-0 1-苯并噻吩-3(2H)-酮 | CAS号95-15-8 苯并噻吩 | CAS号7664-93-9 硫酸 | CAS号141-97-9 乙酰乙酸乙酯 | CAS号147-93-3 硫代水杨酸 | CAS号123-54-6 乙酰丙酮 | CAS号135-13-7 2-羧甲基硫代苯甲酸 | CAS号40142-71-0 3-氨基苯并[b]噻吩-2-羧酸 | CAS号191031-07-9 3-hydroxy-benzo... | CAS号10419-32-6 3-methoxy-1-ben... | CAS号1491-10-7 Benzo[f][1]benz... | CAS号1491-09-4 Benzo[h][1]benz... | CAS号24388-07-6 2-(4-hydroxy-be... | CAS号27751-82-2 3-hydroxy-2-for... | CAS号95-15-8 苯并噻吩 | CAS号1127-35-1 苯并[b]噻吩-3(2H)-酮... | CAS号3844-31-3 (2E)-Δ2,2'-Bi[b... | CAS号314-99-8 7H-benzo[e]benz... | CAS号130-03-0 1-苯并噻吩-3(2H)-酮

合成工艺路线路线简述

    2-羧甲基硫代苯甲酸 反应生成 3-羟基苯并噻吩
    参考文献:De188702
    标题:De188702

    海关参考信息

    专利信息


    专利号:US-2004110228-A1
    优先权日:2002-04-01
    标 题:Combinatorial organic synthesis of unique biologically active compounds
    发明人:MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
    摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

    专利号:US-3943142-A
    优先权日:1969-01-24
    标 题:Dye intermediates and their preparation and use in the synthesis of methine dyes
    发明人:OWEN JOHN R
    权利人:EASTMAN KODAK CO
    摘要:Compositions of matter are provided comprising a stable, non-vaporous monomeric methylene base selected from a 2-methylenethiazoline; a 2-methylenebenzothiazoline; a 2-methylenenaphthothiazoline; a 2-methylenebenzoselenazoline; and a 2-methylenenaphthoselenazoline. The compositions of the invention are prepared by reacting the parent 2-methyl quaternary salt with a non-hydroxylic base which removes a proton of the heterocyclic salt together with a proton acceptor which inhibits build-up of the hydro salt of the non-hydroxylic base, the reaction being conducted under anhydrous conditions in a non-hydroxylic liquid in which the heterocyclic quaternary salt is sufficiently insoluble to inhibit dimer formation. The compositions of the invention are employed in the preparation of methine dyes.

    专利号:US-8329923-B2
    优先权日:2010-06-17
    标 题:4, 4′ disubstituted 4H-cyclopentadithiophene and new methods for synthesizing the same
    发明人:VANDERZANDE DIRK; LUTSEN LAURENCE; VAN MIERLOO SARAH
    权利人:VANDERZANDE DIRK; LUTSEN LAURENCE; VAN MIERLOO SARAH; IMEC; UNIV HASSELT
    摘要:The present preferred embodiments relate to a method for the synthesis of a compound having the following general formula: n nthe method comprising the step of reacting, in presence of a diprotic acid having a negative pKa, a compound having the general formula:n n nwherein R 1 and R 2 are organic groups and wherein X and Y are independently selected from the group consisting of hydrogen, chloro, bromo, iodo, boronic acid, boronate esters, borane, pseudohalogen and organotin. It further relates to compounds so obtained and to compounds resulting from the ring closure of compound (II).

    专利号:US-2007185343-A1
    优先权日:2004-02-26
    标 题 :Metal complexes for use in olefin metathesis and atom group transfer reactions
    发明人:VERPOORT FRANCIS WALTER C; DROZDZAK RENATA A; LEDOUX NELE; ALLAERT BART F
    权利人:UNIV GENT
    摘要:Improved catalysts useful in a number of organic synthesis reactions such as olefin metathesis and atom or group transfer reactions are made by bringing into contact a multi-coordinated metal complex comprising a multidentate Schiff base ligand, and one or more other ligands, with an acid under conditions such that said acid is able to at least partly cleave a bond between the metal and the multidentate Schiff base ligand of said metal complex, optionally through intermediate protonation of said Schiff base ligand.

    专利号:EP-1577282-B1
    优先权日:2004-02-26
    标 题:Metal complexes for use in olefin metathesis and atom or group transfer reactions
    发明人:VERPOORT FRANCIS WALTER CORNELIUS; DROZDZAK RENATA ANNA; LEDOUX NELE; ALLAERT BART FILIP
    权利人:TELENE SAS
    摘要:Improved catalysts useful in a number of organic synthesis reactions such as olefin metathesis and atom or group transfer reactions are made by bringing into contact a multi-coordinated metal complex comprising a multidentate Schiff base ligand, and one or more other ligands, with an acid under conditions such that said acid is able to at least partly cleave a bond between the metal and the multidentate Schiff base ligand of said metal complex, optionally through intermediate protonation of said Schiff base ligand.

    专利号:WO-9845272-A1
    优先权日:1997-04-07
    标题:Topoisomerase inhibitors
    发明人:DEADY LESLIE WILLIAM; DENNY WILLIAM ALEXANDER; KAYE ANTHONY JAMES
    权利人:UNIV LATROBE; DEADY LESLIE WILLIAM; DENNY WILLIAM ALEXANDER; KAYE ANTHONY JAMES
    摘要:The invention provides a novel series of tetracyclic quinoline and quinoxaline carboxamides, bis compounds in which two of the tetracyclic compounds are joined by a linker, and pharmaceutically-acceptable salts and N-oxides thereof, which have the ability to inhibit topoisomerase activity. The compounds are active in vitro and in vivo against tumour cells. Methods of synthesis and pharmaceutical compositions are also claimed.
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    合成参考文献


    摘要:Yoshikai, N.; Rayner, C. M.; Graham, M. A., Science of Synthesis Knowledge Updates, (2020) 2, 53.
    摘要:U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals., NX#09426
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