专利号:US-2004110228-A1 优先权日:2002-04-01 标 题:Combinatorial organic synthesis of unique biologically active compounds 发明人:MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M 摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.
专利号:US-3943142-A 优先权日:1969-01-24 标 题:Dye intermediates and their preparation and use in the synthesis of methine dyes 发明人:OWEN JOHN R 权利人:EASTMAN KODAK CO 摘要:Compositions of matter are provided comprising a stable, non-vaporous monomeric methylene base selected from a 2-methylenethiazoline; a 2-methylenebenzothiazoline; a 2-methylenenaphthothiazoline; a 2-methylenebenzoselenazoline; and a 2-methylenenaphthoselenazoline. The compositions of the invention are prepared by reacting the parent 2-methyl quaternary salt with a non-hydroxylic base which removes a proton of the heterocyclic salt together with a proton acceptor which inhibits build-up of the hydro salt of the non-hydroxylic base, the reaction being conducted under anhydrous conditions in a non-hydroxylic liquid in which the heterocyclic quaternary salt is sufficiently insoluble to inhibit dimer formation. The compositions of the invention are employed in the preparation of methine dyes.
专利号:US-8329923-B2 优先权日:2010-06-17 标 题:4, 4′ disubstituted 4H-cyclopentadithiophene and new methods for synthesizing the same 发明人:VANDERZANDE DIRK; LUTSEN LAURENCE; VAN MIERLOO SARAH 权利人:VANDERZANDE DIRK; LUTSEN LAURENCE; VAN MIERLOO SARAH; IMEC; UNIV HASSELT 摘要:The present preferred embodiments relate to a method for the synthesis of a compound having the following general formula: n nthe method comprising the step of reacting, in presence of a diprotic acid having a negative pKa, a compound having the general formula:n n nwherein R 1 and R 2 are organic groups and wherein X and Y are independently selected from the group consisting of hydrogen, chloro, bromo, iodo, boronic acid, boronate esters, borane, pseudohalogen and organotin. It further relates to compounds so obtained and to compounds resulting from the ring closure of compound (II).
专利号:US-2007185343-A1 优先权日:2004-02-26 标 题 :Metal complexes for use in olefin metathesis and atom group transfer reactions 发明人:VERPOORT FRANCIS WALTER C; DROZDZAK RENATA A; LEDOUX NELE; ALLAERT BART F 权利人:UNIV GENT 摘要:Improved catalysts useful in a number of organic synthesis reactions such as olefin metathesis and atom or group transfer reactions are made by bringing into contact a multi-coordinated metal complex comprising a multidentate Schiff base ligand, and one or more other ligands, with an acid under conditions such that said acid is able to at least partly cleave a bond between the metal and the multidentate Schiff base ligand of said metal complex, optionally through intermediate protonation of said Schiff base ligand.
专利号:EP-1577282-B1 优先权日:2004-02-26 标 题:Metal complexes for use in olefin metathesis and atom or group transfer reactions 发明人:VERPOORT FRANCIS WALTER CORNELIUS; DROZDZAK RENATA ANNA; LEDOUX NELE; ALLAERT BART FILIP 权利人:TELENE SAS 摘要:Improved catalysts useful in a number of organic synthesis reactions such as olefin metathesis and atom or group transfer reactions are made by bringing into contact a multi-coordinated metal complex comprising a multidentate Schiff base ligand, and one or more other ligands, with an acid under conditions such that said acid is able to at least partly cleave a bond between the metal and the multidentate Schiff base ligand of said metal complex, optionally through intermediate protonation of said Schiff base ligand.
专利号:WO-9845272-A1 优先权日:1997-04-07 标题:Topoisomerase inhibitors 发明人:DEADY LESLIE WILLIAM; DENNY WILLIAM ALEXANDER; KAYE ANTHONY JAMES 权利人:UNIV LATROBE; DEADY LESLIE WILLIAM; DENNY WILLIAM ALEXANDER; KAYE ANTHONY JAMES 摘要:The invention provides a novel series of tetracyclic quinoline and quinoxaline carboxamides, bis compounds in which two of the tetracyclic compounds are joined by a linker, and pharmaceutically-acceptable salts and N-oxides thereof, which have the ability to inhibit topoisomerase activity. The compounds are active in vitro and in vivo against tumour cells. Methods of synthesis and pharmaceutical compositions are also claimed.
摘要:Yoshikai, N.; Rayner, C. M.; Graham, M. A., Science of Synthesis Knowledge Updates, (2020) 2, 53. 摘要:U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals., NX#09426