CAS: 5331-43-1; Benzyl Hydrazinecarboxylate

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CAS号22129-07-3 benzyl 1H-imida... | CAS号3459-92-5 碳酸二苄酯 | CAS号501-53-1 氯甲酸苄酯 | CAS号202980-89-0 1-benzyl 2-(2,2... | CAS号13795-24-9 苄基硝苯基碳酸酯 | CAS号6294-89-9 肼基甲酸甲酯 | CAS号100-51-6 苯甲醇 | CAS号100-44-7 氯化苄 | CAS号57699-88-4 2-(叔丁基)肼-1,2-二羧... | CAS号185456-24-0 benzyl N-[bis[(... | CAS号202980-91-4 B°C,Z-NNH-B°C | CAS号3459-92-5 碳酸二苄酯 | CAS号103-41-3 肉桂酸苄酯 | CAS号154972-38-0 2-(叔丁氧基羰基)六氢吡嗪-... | CAS号135942-00-6 benzyl N-(2-met... | CAS号127799-53-5 1-Cbz-2-B°C-1-甲肼 | CAS号135942-02-8 benzyl N-(benzy... | CAS号67600-79-7 吡唑烷-1-羧酸苄酯

氯甲酸苄酯置于一水合肼体系中,用 乙醚 作为反应溶剂,化学反应 1.0H,以82%的收率获得产物肼基甲酸苄酯
参考文献:苄氧基(4-取代苄氧基)卡宾.恶二唑啉的反应生成和溶液中自由基对的裂解
标题:苄氧基(4-取代苄氧基)卡宾.恶二唑啉的反应生成和溶液中自由基对的裂解
摘要:2,2-二苄氧基-5,5-二甲基-δ3-1,3,4-恶二唑啉在苯中在 110oc 下的热解产生二苄氧基卡宾.用叔丁醇捕获卡宾,得到原甲酸二苄基叔丁酯.在没有卡宾捕获剂的情况下,它会分裂为苄氧羰基和苄基自由基,如用 Tempo 捕获后者所示.在不存在 Tempo 和叔丁醇的情况下,自由基在与苯乙酸苄酯偶联和脱羧之间分配,随后形成联苄.通过比较两种可能的酯 Arch2O(Co)Ch2Ph 和 Phch2O(Co)Ch2Ar 的产率,确定了类似的卡宾从苄氧基-(P-取代的-苄氧基)卡宾的优选断裂意义.发现对位的吸电子基团有利于裂解为含有该基团的苄基.数据的哈米特图与 σ-取代基常数 (R = 0.994,ρ(Phh,110oc) = 0.7) 给出了最佳拟合,表明 ...
DOI:10.1139/v00-078

专利信息

专利号:US-2013012706-A1
优先权日:2010-03-01
标 题 :Methods and Intermediates for the Synthesis of 4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]tetrazines
发明人：HUMMERSONE MARC GEOFFERY; COUSIN DAVID
权利人:PHARMINOX LTD; HUMMERSONE MARC GEOFFERY; COUSIN DAVID
摘要:The present invention provides a compound of general formula (II), or a salt or solvate thereof: n n n n n n n n n n n n wherein n A is independently -A 1 , -A 2 , -A 3 , -A 4 , -A 5 , -A 6 , or -A 7 , wherein:n -A 1 is independently C 5-12 heteroaryl, and is optionally substituted; -A 2 is independently thioamido or substituted thioamido; -A 3 is independently imidamido, substituted imidamido, N-hydroxyimidamido, or substituted N-hydroxyimidamido; -A 4 is independently hydroxamic acid or hydroxamate; -A 5 is independently carboxamide or substituted carboxamide; -A 6 is independently aliphatic C 2-6 alkenyl, and is optionally substituted; and -A 7 is independently carboxy or C 1-4 alkyl-carboxylate;n nand its use in the synthesis of temozolomide and analogues thereof.

专利号:US-7786156-B2
优先权日:2004-01-28
标 题 :Synthesis methods and intermediates for the manufacture of Rizatriptan
发明人：MARTIN PIERRE; BERENS ULRICH; BOUDIER ANDREAS; DOSENBACH OLIVER
权利人:RATIOPHARM GMBH
摘要:The invention relates to a process for the manufacture of an 1,2,4-triazol-1-yl compound of the formula [A], n nor a salt thereof, wherein each of R3 and R4 is hydrogen or lower alkyl, said process comprising reacting a hydrazine compound of the formula [B]n n nwherein R is hydrogen or acyl, R2 is hydrogen or a protecting group, are hydrogen or lower alkyl, and R6 is hydrogen or COOR7, or a salt thereof, with a 1,2,4-triazolyl forming reagent.n n In addition, novel intermediates for the synthesis of the anti-migraine agent Rizatriptan and methods for their synthesis are presented.

专利号:US-2020354404-A1
优先权日:2019-05-09
标 题 :Peptidomimetic agents, synthesis and uses thereof
发明人：AL-ABED YOUSEF
权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
摘要:Compounds for use in synthesis of peptidomimetic agents; synthesis of peptidomimetic agents; peptidomimetic diagnostic and therapeutic agents; and uses of the compounds and peptidomimetic agents in drug discovery, diagnosis, prevention and treatment of diseases are described.

专利号:US-10906895-B2
优先权日:2017-02-16
标 题:Processes for the preparation of benzodiazepine derivatives
发明人：KIM IN JONG; YU JIANMING; BLAISDELL THOMAS P; Panarese Joseph; SHOOK BRIAN C; OR YAT SUN
权利人:ENANTA PHARM INC
摘要:The present invention relates to processes and intermediates useful in the preparation of biologically active molecules, especially in the synthesis of Respiratory Syncytial Virus (RSV) inhibitors. The present invention also relates to processes and intermediates for the preparation of compounds of formula (I): n n n n n n n n n n In particular, the present invention also relates to processes and intermediates for the preparation of compound I-a:

专利号:WO-2024143052-A1
优先权日:2022-12-26
标题 :Peptide synthesis method
发明人：HOJO KEIKO; TSUDA YUKO
权利人:KOBE GAKUIN EDUCATIONAL FOUND
摘要:To provide a peptide synthesis method that is simpler, more efficient, and/or more environmentally friendly.　Provided is a peptide synthesis method that includes bringing a mixed dispersion of a protected amino acid for peptide synthesis, a base, a water-soluble condensing agent, and an aqueous solvent into contact with an amino acid and/or a peptide and inducing a condensation reaction of the protected amino acid for peptide synthesis and the amino acid and/or peptide.

专利号:US-11639336-B2
优先权日:2018-06-08
标 题:Preparation method for S-indoxacarb
发明人：BO LEIFANG; CHENG DAOQUAN; LIU JIANCHENG; FENG PEILIANG; LIU HUAMIN; WANG ZHONGYANG
权利人:SHANDONG JINGBO AGROCHEMICALS TECH CO LTD
摘要:A catalyst and a method for preparing S-indoxacarb using the catalyst. The catalyst is prepared using 3-tert-butyl-5-(chloromethyl)salicylaldehyde and cyclohexanediamine as raw materials, where an original quinine catalyst such as cinchonine is replaced with the catalyst for application in the asymmetric synthesis of tert-butyl hydroperoxide and 5-chloro-2-methoxycarbonyl-1-indanone ester, greatly improving selection in the asymmetric synthesis process, with the S-enantiomer content increasing from 75% to over 98%, achieving the recycling of a high-efficiency chiral catalyst, and greatly reducing production costs. The synthesis process of the catalyst is simple and is favorable for industrialization, and lays good foundations for the production of high-quality indoxacarb.