CAS: 534-13-4; 1,3-Dimethylthiourea

该化合物是一种硫尿素衍生物,配有分子式C3H8N2S. 它通常用作各种化学工艺中的消毒剂,硫化加速器和稳定剂. 化合物具有极好的热稳定性和反应性, 适合聚合化学,橡胶制造和有机合成的应用. 它作为激进拾荒者的能力也能够用于腐蚀抑制和光化研究. N, N'-Dimethiourea的特点是其高纯度和一贯性能,确保工业和研究环境中的可靠结果. 建议进行适当的处理和储存,因为它对湿度和氧化性条件敏感.

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合成工艺路线路线简述

    N,N'-Dimethylthioperoxydicarbamic Acid 反应生成 N,N'-二甲基硫脲
    参考文献:Nambury; Chaturvedi,1957,Vol. 8,P. 86,90
    标题:Nambury; Chaturvedi,1957,Vol. 8,P. 86,90

    海关参考信息

    专利信息


    专利号:US-4627968-A
    优先权日:1984-09-10
    标 题 :Synthesis of crystalline aluminosilicate with alkylurea or alkylthiourea
    发明人:KAI TADASHI
    权利人:ASAHI CHEMICAL IND
    摘要:In the synthesis of a crystalline aluminosilicate by heating an aqueous mixture containing a silica source, an alumina source and an alkali metal source, at least one compound selected from lower alkylureas and lower alkylthioureas is permitted to co-exist with the mixture.

    专利号:US-9809565-B2
    优先权日:2013-07-05
    标 题 :Formation of chiral 4-chromanones using chiral pyrrolidines in the presence of ureas or thioureas
    发明人:LETINOIS ULLA; NETSCHER THOMAS; ACKERMANN STEPHAN
    权利人:DSM IP ASSETS BV
    摘要:The present invention relates to a synthesis of chromanones or chromanes in a stereospecific matter in view of the 2-position in the chromanone or chromane ring. It has been found that this synthesis is particularly possible in the presence of a chiral compound of formula of a specific type and of at least one urea or thiourea.

    专利号:WO-2014011120-A1
    优先权日:2012-07-13
    标 题 :Endoperoxides, synthesis and uses thereof for the treatment of neoplastic diseases such as cancer
    发明人:TAN NGUAN SOON; CHIBA SHUNSUKE
    权利人:UNIV NANYANG TECH
    摘要:The present invention generally relates to processes and methods for the synthesis of endoperoxide compounds. More specifically, the invention relates to a method for preparing endoperoxide compounds starting from an aryl imine of formula (I) in the presence of a metallic catalyst and oxygen. The present invention also relates to endoperoxide compounds of formula (III) and their pharmaceutically acceptable salts thereof, useful for therapy. All substituents are defined herein. Also disclosed are methods of treating cancer using the compounds of formula (III).

    专利号:US-2023303546-A1
    优先权日:2020-03-05
    标题:Process And Intermediates For The Preparation Of Pyroxasulfone
    发明人:RECSEI CARL; BARDA YANIV
    权利人:ADAMA AGAN LTD
    摘要:The invention relates to a process for preparing a key intermediate of Formula (I) in the synthesis of pyroxasulfone. The process comprises reacting an isoxazole of Formula (II) with a thionating reagent to create an S-substituted thioisoxazole of Formula (III); and combining the S-substituted thioisoxazole of Formula (III) with a pyrazole of the Formula (IV) by introducing a methylene bridge, to obtain a compound of Formula (I). The invention also relates to novel S-substituted thioisoxazole of Formula (III) and processes of preparation thereof, wherein L1 is halogen or an anionic residue derived from an acid; R is an organic residue derived from a suitable thionating reagent: dimethyl thioformamide, thiosulfate salts, dithiooxamide, alkyl xanthate salts, thiobenzamide, V-substituted thiourea and thioacetate salts.

    专利号:US-8193180-B2
    优先权日:2007-01-24
    标 题 :N-amino tetrahydrothiazine derivatives, method of manufacture and use
    发明人:BRARD LAURENT; SINGH RAKESH KUMAR; KIM KYU KWANG; SAULNIER-SHOLLER GISELLE
    权利人:BRARD LAURENT; SINGH RAKESH KUMAR; KIM KYU KWANG; SAULNIER-SHOLLER GISELLE; WOMEN & INFANTS HOSPITAL
    摘要:This invention comprises the innovative synthesis of N-amino tetrahydrothiazine free bases and their salts. This invention further comprises the use of the derivatives and their therapeutic application as anticancer agents. Further this invention comprises their manufacture and use.

    专利号:US-11702347-B2
    优先权日:2019-11-12
    标 题:Synthesis of mixed metal chalcogenides using solid phase method
    发明人:ENHESSARI MORTEZA; SALEHABADI ALI; KHOOBI ASMA
    权利人:ENHESSARI MORTEZA; SALEHABADI ALI; KHOOBI ASMA; NARAGH BRANCH ISLAMIC AZAD UNIV
    摘要:An exemplary method for producing a mixed metal chalcogenide under atmospheric pressure may include forming a reaction mixture by mixing a first metal chalcogenide and a second metal chalcogenide. An exemplary method may further include pouring a first layer of NaCl within a reactor, where an exemplary reactor may include a container and a cap. Pouring an exemplary first layer of NaCl within an exemplary reactor may include pouring an exemplary first layer of NaCl on an exemplary base end of an exemplary container of the exemplary reactor. An exemplary method may further include pouring an exemplary reaction mixture into an exemplary container on top of an exemplary first layer of NaCl, pouring a second layer of NaCl into an exemplary container on top of an exemplary reaction mixture, sealing an exemplary container by closing an exemplary cap and pouring molten NaCl on top of the exemplary cap, and heating an exemplary reactor at a predetermined temperature for a predetermined time.
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    主要参考文献

    [参考文献]: Yoshiji Ohta, Et Al. Protective Effect Of N,N'-Dimethylthiourea Against Stress-Induced Gastric Mucosal Lesions In Rats. Fundam Clin Pharmacol. 2017 Jun;31(3):319-328.
    [参考文献]: Zhongyi Zhang, Et Al. Analysis Of Volatile Compounds In Fermented Black Garlic By Gc-Ms.

    合成参考文献


    摘要:Jang, H. B.; Oh, J. S.; Song, C. E., Science of Synthesis: Asymmetric Organocatalysis, (2012) 2, 137.
    摘要:Chebanov, V. A.; Gorobets, N. Yu.; Sedash, Yu. V., Science of Synthesis: Multicomponent Reactions, (2013) 1, 41.
    摘要:Huynh, H. V.; Yuan, D., Science of Synthesis: N-Heterocyclic Carbenes in Catalytic Organic Synthesis, (2016) 1, 39.
    摘要:Teratology, The International Journal of Abnormal Development., 23(335), 1981 []
    摘要:Schafer, E. W., Jr., and W. A. Bowles Jr. 1985. Acute oral toxicity and repellency of 933 chemicals to house and deer mice. Archives of Environmental Contamination and Toxicology 14:111-129. https://www.aphis.usda.gov/ws/nwrc/chem-effects-db/S_schafer851.pdf
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