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参考文献:Cγ(s / R)-双峰肽核酸(cγ-Bm-Pna)通过同步结合到两个互补dna链上形成双双链.
标题:Cγ(s / R)-双峰肽核酸(cγ-Bm-Pna)通过同步结合到两个互补dna链上形成双双链.
摘要:肽核酸(pna)是具有中性无环聚酰胺骨架的dna的线性等价物,该骨架具有通过叔酰胺键连接在氨基乙基甘氨酸重复单元上的核碱基.它们以序列特异性结合互补的dna或rna,形成比相应dna / Rna自双链体更稳定的杂交体.一种新型的pna称为双峰pna [cγ(小号/ [r)-Bm-Pna]被设计成具有通过酰胺垫片附着到侧链上cγ的重复的第二核碱基aeg Pna寡聚物的单元.已证明每个aeg单元具有两个核碱基的cγ-双峰pna低聚物可同时结合两个不同的互补dna,从两者形成双链体叔酰胺侧和cγ侧.在此类pna:Dna三元复合物中,两个双链体共享一个公共的pna主链.三元dna 1:Cγ(小号/ [r)-Bm-Pna:Dna 2种复合物显示出比分离的双链体更好的热稳定性,和cγ(小号)-Bm-Pna双链体更稳定比cγ([r)-Bm-Pna双工.双峰pna是可通过天然碱基
DOI:10.1021/acs.Joc.0C01853

专利信息

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.