CAS: 6980-08-1; 4-Chloro-3-Nitropyridin-2-Amine

相似化合物

24484-98-8 37660-64-3 662116-67-8

上下游产品

4-chloro-3-nitropyridine N-nitro-2-amino-4-chloropyridine 2-Amino-4-chloropyridine 4-methoxy-3-nitro-pyridin-2-ylamine 4-(3-aminophenoxy)-3-nitropyridin-2-amine 4-(3-N-(tert-butoxycarbonyl)aminophenoxy)-3-nitropyridin-2-amine 4-chloro-2,3-diaminopyridine

2-氨基-4-氯吡啶置于硫酸,硝酸体系中,化学反应 120.0H,以42%的收率获得产物2-氨基-3-硝基-4-氯吡啶
参考文献:发现3H-咪唑并[4,5-B]吡啶作为强效c-Met激酶抑制剂:设计,合成和生物学评估
标题:发现3H-咪唑并[4,5-B]吡啶作为强效c-Met激酶抑制剂:设计,合成和生物学评估
摘要:为了鉴定新型的c-Met抑制剂,分析了人类kinome的序列和晶体结构,以发现在酪氨酸激酶亚家族中未得到充分研究的有趣的铰链结合剂.通过这项研究,咪唑并吡啶环被选作新型c-Met铰链结合抑制剂支架.制备了一系列衍生物,并研究了结构-活性关系.其中,一种化合物尤其在酶和细胞分析中表现出出色的活性,非常好的体外代谢稳定性和非常好的药代动力学参数.口服给药时,该化合物在nih-3T3 / Tpr-Met异种移植模型中抑制肿瘤生长,并且对体重没有不利影响.
DOI:10.1002/cmdc.201200120

专利信息

专利号:US-9708317-B2
优先权日:2013-11-25
标 题 :Process for the preparation of 8-(4-aminophenoxy)-4H-pyrido[2,3-B]pyrazin-3-one derivatives
发明人：ZAMBON ALFONSO; NICULESCU-DUVAZ DAN; CHUBB RICHARD; SPRINGER CAROLINE JOY
权利人:CANCER RES TECH LTD; INST OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (THE); OXY SCIENT LTD; THE INST OF CANCER RESEARCH: ROYAL CANCER HOSPITAL
摘要:The present invention pertains generally to the field of organic chemical synthesis, and in particular to certain methods for the synthesis of 8-(4-aminophenyoxy)-4H-pyrido[2,3-b]pyrazin-3-one and related compounds (denoted herein as (3)) from 4-(4-aminophenyoxy)pyridine-2,3-diamine and related compounds (denoted herein as (1)), by reaction with glyoxylic acid (denoted herein as (2)). The compounds (3) are useful in the synthesis of known anti-cancer agents, such as 1-(5-tert-butyl-2-(4-methyl-phenyl)-pyrazol-3-yl)-3-[2-fluoro-4-[(3-oxo-4H-pyrido[2,3-b]pyrazin-8-yl)oxy]phenyl]urea.

专利号:US-3963734-A
优先权日:1971-09-17
标 题:Lower alkylsulfonyl 2-amino, 3-nitro pyridines
发明人：DOHERTY GEORGE O P; FUHR KENNETH H
权利人:LILLY CO ELI
摘要:Substituted 1-hydroxy-2-(1,1-difluoroalkyl)-1H-imidazo-(4,5-b)pyridine compounds useful as herbicides; and intermediates useful in the synthesis of these compounds. In addition to exhibiting herbicidal activity, the substituted 1-hydroxy-2-(1,1-difluoroalkyl)-1H-imidazo(4,5-b)pyridine compounds are of low mammalian toxicity.

专利号:US-4087432-A
优先权日:1974-05-23
标 题 :1H-imidazo(4,5-b)pyridine compounds
发明人：O DOHERTY GEORGE O P; FUHR KENNETH H
权利人:LILLY CO ELI
摘要:Substituted 1-hydroxy-2-(1,1-difluoroalkyl)-1H-imidazo-(4,5-b)pyridine compounds useful as herbicides; and intermediates useful in the synthesis of these compounds. In addition to exhibiting herbicidal activity, the substituted 1-hydroxy-2-(1,1-difluoroalkyl)-1H-imidazo(4,5-b)pyridine compounds are of low mammalian toxicity.

专利号:US-3813408-A
优先权日:1970-03-20
标 题:1h-imidazo(4,5-b)pyridine compounds
发明人：DOHERTY G; FUHR K
权利人:LILLY CO ELI
摘要:SUBSTITUTED 3-HYDROXY-2 - (1,1 - DIFLUOROALKYL) - 1HIMIDAZO(4,5-B)PYRIDINE COMPOUNDS USEFUL AS HERBICIDES; AND INTERMEDIATES USEFUL IN THE SYNTHESIS OF THESE COMPOUNDS. IN ADDITION TO EXHIBITING HERBICIDAL ACTIVITY, THE SUBSTITUTED 1 - HYDROXY-2-(1,1-DIFLUOROALKYL)-1H-IMIDAZO(4,5-B)PYRIDINE COMPOUNDS ARE OF LOW MAMMALIAN TOXICITY.

专利号:US-3968116-A
优先权日:1971-09-17
标 题 :1H-imidazo(4,5-b)pyridine compounds
发明人：DOHERTY GEORGE O P; FUHR KENNETH H
权利人:LILLY CO ELI
摘要:Substituted 1-hydroxy-2-(1,1-difluoroalkyl)-1H-imidazo-(4,5-b)pyridine compounds useful as herbicides; and intermediates useful in the synthesis of these compounds. In addition to exhibiting herbicidal activity, the substituted 1-hydroxy-2-(1,1-difluoroalkyl-1H-imidazo(4,5-b)pyridine compounds are of low mammalian toxicity.

专利号:CN-103561576-A
优先权日:2011-03-08
标题 :Heterocyclic regulators of lipid synthesis