CAS: 89412-79-3; (4As,6As,6Br,8Ar,10S,12Ar,12Br,14Bs)-10-(((2S,3R,4S,5S)-3-(((2S,3R,4S,5S,6R)-4,5-Dihydroxy-6-(Hydroxymethyl)-3-(((2S,3R,4R,5R,6S)-3,4,5-Trihydroxy-6-Methyltetrahydro-2H-Pyran-2-yl)Oxy)Tetrahydro-2H-Pyran-2-yl)Oxy)-4,5-Dihydroxytetrahydro-2H-Pyran-2-yl)Oxy)-2,2,6A,6B,9,9,12A-Heptamethyl-1,3,4,5,6,6A,6B,7,8,8A,9,10,11,12,12A,12B,13,14B-Octadecahydropicene-4A(2H)-Carboxylic Acid

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CAS号124961-61-1 红背银莲花皂甙R8

Benzyl Oleanolate 3-O-α-L-Rhamnopyranosyl-(1->2)-3'',4'',6''-Tri-O-Benzyl-β-D-Glucopyranosyl-(1->2)-α-L-Arabinopyranoside置于palladium 10% On Activated Carbon,氢气,溶剂黄146体系中,用 甲醇 作为反应溶剂,20.0 °C,800.01 Kpa 条件下,反应 24.0H,以83%的收率获得产物竹节香附素a
参考文献:Synthesis And Biological Evaluation Of Raddeanin A,A Triterpene Saponin Isolated From Anemone Raddeana
标题:Synthesis And Biological Evaluation Of Raddeanin A,A Triterpene Saponin Isolated From Anemone Raddeana
摘要:首先,合成了一种具有细胞毒性的齐墩果酸类三萜皂甙 Raddeanin A,它是从 Anemone Raddeana Regel 中分离出来的.以齐墩果酸为原料,以阿拉伯糖基,葡萄糖基和鼠李糖基三氯乙酰亚氨酸为供体,采用逐步糖基化的方法进行合成.通过 1H-NMR,13C-NMR,Ir,Ms 和元素分析确认了 Raddeanin A 的化学结构,阐明其结构为 3-O-α-L-Rhamnopyranosyl-(1->2)-β-D-Glucopyranosyl-(1->2)-α-L-Arabinopyranoside Oleanolic Acid.生物活性测试表明,在低浓度范围内,Raddeanin A 对组蛋白去乙酰化酶(hdacs)具有中等程度的抑制活性,这表明 Raddeanin A 的 Hdacs 抑制活性可能是其细胞毒性的原因之一.
DOI:10.1248/cpb.C14-00138