CAS: 31087-44-2; (R)-2-Pentanol

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[ECHA物质

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CAS号39180-02-4 benzoate de pen... | CAS号6032-29-7 仲戊醇 | CAS号107-87-9 2-戊酮 | CAS号109-66-0 正戊烷 | CAS号57984-70-0 pent-3-yn-2-ol | CAS号57984-71-1 phthalic acid m... | CAS号64584-92-5 (R)-(-)-4-烯基-2-戊醇 | CAS号64-19-7 冰醋酸 | CAS号107-87-9 2-戊酮 | CAS号107-81-3 2-溴戊烷 | CAS号26184-62-3 (S)-(+)-2-戊醇

专利信息

专利号:US-7750135-B2
优先权日:2006-07-28
标题:Molecular design of thermostable alcohol dehydrogenase for synthesis for chiral aromatic alcohols
发明人：ZEIKUS J GREGORY; ZIEGELMANN-FJELD KARLA I; VIEILLE CLAIRE
权利人:UNIV MICHIGAN STATE
摘要:The present invention relates to compositions and methods utilizing thermostable and novel alcohol dehydrogenase enzymes for biosynthesizing chiral specific molecules for use as precursor molecules in synthesizing pharmaceutical compounds. Particularly, in preferred embodiments, the invention relates to directed engineering of an enzymatic catalytic site of an alcohol dehydrogenase enzyme gene for enhancing enantioselectivity for (S)-enantiomer substrate catalytic activity for providing aryl (S)-enantiomer products in stereomeric excess.

专利号:US-7465838-B2
优先权日:2002-10-01
标题:Chiral diols, their manufacture and ligands and catalysts derived therefrom
发明人：BERENS ULRICH
权利人:CIBA SPECIALTY CHEMICAL CORP
摘要:The present invention relates to a method for the preparation of C 2 -symmetric 1,4-diols of the formula IVA or IVB, wherein ring A, R 1 and R 2 have the meanings given in the specification, that makes use of the metallation of pure enantiomers of α-(aryl or heteroaryl)-α-substituted alkanol compounds or the use of said alkanol compounds in the preparation of said mmetric 1,4-diols; novel C 2 -symmetric 1,4-diols in enantiomerically pure form; and methods of use or their use in the synthesis of chiral ligands which find use to produce catalysts for a variety of asymmetric transformations such as hydrogenations.

专利号:US-6929935-B2
优先权日:2001-12-19
标 题 :Gluconobacter oxydans 2-ketoreductase enzyme and applications thereof
发明人：NANDURI VENKATA B; JOHNSTON ROBERT M; GOLDBERG STEVEN L; CINO PAUL M; PATEL RAMESH N
权利人:BRISTOL MYERS SQUIBB CO
摘要:This invention relates to an novel Gluconobacter oxydans 2-ketoreductase useful for the synthesis of chiral alcohols. Also related are isolated nucleic acids encoding G. oxydans 2-ketoreductase enzymes, and enzyme fragments and variants thereof, as well as vectors and host cells comprising these nucleic acids. Further related are isolated G. oxydans 2-ketoreductase polypeptides, and fragments and variants thereof, and antibodies that specifically bind to G. oxydans 2-ketoreductase polypeptides, fragments, or variants. The invention also relates to methods of obtaining isolated G. oxydans 2-ketoreductase nucleic acids, polypeptides, and antibodies, and methods of using G. oxydans 2-ketoreductase in various reactions for industrial or pharmaceutical applications.

专利号:US-2008220487-A1
优先权日:2006-07-28
标题:Molecular design of thermostable alcohol dehydrogenase for synthesis for chiral aromatic alcohols