CAS: 329-63-5; Dl-Adrenaline Hydrochloride

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CAS号87697-27-6 N-(tert-butoxyc...

N-(叔丁氧羰基)肾上腺素置于甲醇,三甲基氯硅烷体系中,化学反应 3.0H,以100%的收率获得产物肾上腺素盐酸盐
参考文献:天然存在的儿茶酚胺合成的新途径
标题:天然存在的儿茶酚胺合成的新途径
摘要:儿茶酚胺,拟交感神经药和肾上腺素能受体拮抗剂已通过2-碘氧基苯甲酸(ibx)在均相和非均相条件下将相应的4-羟基苯乙胺衍生物进行区域选择性氧化,然后裂解氨基保护基来制备.通过使用聚合物支撑的ibx,在第一次氧化后,氧化剂可以被回收,再生并有效地再使用几次.还已经报道了一种合成许多药物关键成分的n-(甲氧基羰基)多巴胺的有效,简便和绿色的方法. N-(甲氧羰基)多巴胺-儿茶酚胺-芳族羟基化-2-碘氧基苯甲酸-聚合物负载的ibx
DOI:10.1055/s-0029-1217027

专利信息

专利号:WO-2012164484-A1
优先权日:2011-05-30
标 题:Adenosine or deoxyadenosine derivatives modified at position 8 and a method of synthesis thereof
发明人：CAPOBIANCO MASSIMO LUIGI; NAVACCHIA MARIA LUISA
权利人:CONSIGLIO NAZIONALE RICERCHE; CAPOBIANCO MASSIMO LUIGI; NAVACCHIA MARIA LUISA
摘要:New derivatives of adenosine and deoxyadenosine modified at position 8 of the purine ring, of general formula (I) are described, which are suitable to be conjugated with functional molecules such as chromophores, fluorophores and intercalating residues, and suitable to be incorporated within synthetic oligonucleotides. A method for the synthesis of the above-mentioned derivatives is also described, which allows the obtainment thereof in high yields and by simple methods. Formula (I), wherein Z is selected from (a) and (b).

专利号:US-3901824-A
优先权日:1973-08-03
标题:New catalyst in the direct synthesis of dimethyltin dichloride
发明人：KNEZEVIC VASILIJE; POLLOCK MARK W; LIAUW KOEI-LIANG; SPIEGELMAN GERALD
权利人:WITCO CHEMICAL CORP
摘要:Dimethyltin dichloride is prepared by reacting tin metal with methyl chloride at 65*-230*C. in the presence of a catalyst system consisting of tin tetrachloride and trihydrocarbyl phosphine or trihydrocarbyl amine, having 3-24 carbon atoms. The trihydocarbyl amine or trihydrocarbyl phosphine may be quaternized before use. Pure dimethyltin dichloride is obtained in high yields and very light color with little or no toxic trimethyltin chloride without the need of recycling or other subsequent chemical purification. The process can be operated at atmospheric or elevated pressure.

专利号:US-3901899-A
优先权日:1973-04-27
标题 :Synthesis of indoles from anilines and intermediates therein
发明人：GASSMAN PAUL G
权利人:UNIV OHIO STATE RES FOUND
摘要:Preparing indoles and intermediates therefor by reacting an Nhaloaniline with a Beta -carbonylic hydrocarbon sulfide to form an azasulfonium halide, reacting the azasulfonium halide with a strong base to form a thio-ether indole derivative, and then reducing the thio-ether indole, e.g. with Raney nickel, to form the indole compound. When an acetal or ketal of the Beta carbonyl hydrocarbon sulfide is used, the azasulfonium salt is treated with a base, and then with an acid to form the thio-ether indole derivative. When an Alpha -ethyl- Beta -carbonylic hydrocarbon sulfide is used, the resulting azosulfonium salt reacts with strong base to form a thio-ether indolenine derivative, which on reduction with Raney nickel or complex metal hydrides yields 3-substituted indoles. The aniline may be an aminopyridine to form an aza-indole compound in the process. The azasulfonium salts and thio-ether indole or thio-ether indolenine derivatives can be isolated and recovered from their respective reaction mixtures. The thio-ether-indole and thio-ether indolenine derivatives are useful as intermediates to make the indoles without the thio-ether group. The indoles are known compounds having a wide variety of uses, e.g., in making perfumes, dyes, amino acids, pharmaceuticals, agricultural chemicals and the like.

专利号:US-10618030-B2
优先权日:2016-06-30
标 题:Metal oxide-based biocompatible hybrid sorbent for the extraction and enrichment of catecholamine neurotransmitters and related compounds, and method of synthesis
发明人：MALIK ABDUL; ALHENDAL ABDULLAH AWADH
权利人:UNIV SOUTH FLORIDA
摘要:The subject invention concerns metal or metalloid oxide-based sol-gel hybrid sorbent and methods of synthesis. In one embodiment, the sorbent is a ZrO 2 polypropylene oxide based sol-gel. The subject invention also concerns a hollow tube or capillary internally coated with a sorbent of the invention. Sorbent coated tubes and capillaries of the invention can be used in extraction and/or enrichment of samples to be analyzed for catecholamines and related compounds.

专利号:US-3301637-A
优先权日:1962-12-27
标 题 :Method for the synthesis of gallium phosphide
发明人：KUCZA JOSEPH A; MOUNT KISCO; GERALD MANDEL
权利人:IBM

专利号:NZ-759478-A
优先权日:2013-12-05
标题:Synthesis of trans-8-chloro-5-methyl-1-[4-(pyridin-2-yloxy)-cyclohexyl]-5,6-dihydro-4h-2,3,5,10b-tetraaza-benzo[e]azulene and crystalline forms thereof