专利号:US-2024052097-A1 优先权日:2021-02-08 标题 :Synthesis of peg-based thiol-norbornene hydrogels with tunable hydroylitic degradation properties 发明人:LIN CHIEN-CHI; LIN FANG-YI 权利人:UNIV INDIANA TRUSTEES 摘要:Methods for synthesizing a hydrogel having tunable hydrolylic degradation kinetics according to certain embodiments include synthesizing a norborene-functionalized polyethylene glycol macromer having an ester linkage between a polyethylene glycol domain of the macromer and a norbornene domain of the macromer and having a carboxyl group on the norbornene; and reacting a quantity of such macromers with a quantity of dithiol molecules by an ultraviolet-initiated photo-gelation reaction to yield a hydrogel. Such macromers and such hydrogels form additional aspects of the disclosure, as do a wide variety of methods for tuning and for using such hydrogels.
专利号:WO-2022170012-A1 优先权日:2021-02-08 标 题:Synthesis of peg-based thiol-norbornene hydrogels with tunable hydroylitic degradation properties