CAS: 35779-04-5; 1-(Tert-Butyl)-4-Iodobenzene

上下游产品

4-tert-Butylaniline iodobenzene isobutyryl chloride tert-butylbenzene bis(4-tert-butylphenyl)amine tButyl iodobenzenedichloride4-tButyl iodobenzenedichloride 4,4'-di-tert-butylbiphenyl 1-(tert-butyl)-4-iodosylbenzene

4-叔丁基苯胺置于氢气,Sodium Nitrite,氢碘酸体系中,用 水 用作溶剂,以40%的收率获得1-叔丁基-3-碘苯
参考文献:芳基和乙烯基自由基的反应性:氢原子的提取或与亲核试剂的反应
标题:芳基和乙烯基自由基的反应性:氢原子的提取或与亲核试剂的反应
摘要:芳基和乙烯基自由基(两种基本的瞬态中间体)的反应性已经针对两个基本过程进行了研究:H 原子提取和与亲核试剂的反应(y-,在 Srn1 反应中).感兴趣的自由基是通过使用 Bu3Snh/aibn 系统或通过来自亲核试剂的光刺激电子转移从卤代芳烃或卤乙烯前体产生的,并且研究了竞争途径之间的中间自由基的分配.使用间接方法(例如研究竞争实验中的反应产物;使用自由基钟探针)和直接方法(例如通过闪光光解实验检测自由基)使以下速率常数成为获得(25 oc 时 M-1.s-1 中的所有值).对于苯基型自由基,确定了从溶剂 Me2So (2.8.106) 和 Ch3Cn (6.7.106) 中提取 H 的速率常数 (Kh) 以及与亲核试剂 (Ky) 如 Me3Ccoch2-离子 (3.3.109) 结合的速率常数.对于乙烯基自由基 Ph2C=c(.)Ph (7.),来自 Me2So (1.1.105),Ch3Cn
Doi:10.1002/1099-0690(200208)2002:16<2844::Aid-Ejoc2844>3.0.Co;2-9

专利信息

专利号:US-2015239796-A1
优先权日:2014-02-19
标题:One pot synthesis of 18f labeledtrifluoromethylated compounds with difluoro(iodo)methane
发明人：RüHL THOMAS; RISS PATRICK; RAFIQUE WAQAS
权利人:UNIV OSLO
摘要:The present invention relates to compositions and methods for the synthesis of 18 F labeled compounds. In particular, the present invention relates to a copper (I) mediated one pot method for 18 F-trifluoromethylation of aromatic- or heteroaromatic halides with difluoro(iodo)methane (e.g., for use at PET imaging agents).

专利号:US-8053161-B2
优先权日:2006-09-25
标 题 :Resist composition, resin for use in the resist composition, compound for use in the synthesis of the resin, and pattern-forming method using the resist composition
发明人：WADA KENJI; SAEGUSA HIROSHI
权利人:FUJIFILM CORP
摘要:A resist composition comprises: (A) a resin capable of increasing its solubility in an alkali developer by action of an acid; (B) a compound capable of generating an acid upon irradiation with actinic ray or radiation; (C) a resin having at least one of a fluorine atom and a silicon atom; and (D) a solvent, wherein the resin (C) has a degree of molecular weight dispersion of 1.3 or less and a weight average molecular weight of 1.0×10 4 or less.

专利号:US-2009131660-A1
优先权日:2006-04-03
标 题 :SYNTHESIS OF 3-[4-(1,1-DIMETHYL-PROPYL)-PHENYL]-2-METHYL-PROPIONALDEHYDE AND cis-4--2,6-DIMETHYL-MORPHOLINE (AMOROLFINE)
发明人：BOITEAU JEAN-GUY; MUSICKI BRANISLAV
权利人:GALDERMA SA
摘要:3-[4-(1,1-Dimethyl-propyl)-phenyl]-2-methyl-propionaldehyde and cis-4-{3-[4-(1,1-dimethyl-propyl)-phenyl]-2-methyl-propyl}-2,6-dimethyl-morpholine (Amorolfine) are synthesized, first by Heck reacting a compound of general formula (VI): n n n n n n n n n n with 2-methyl-prop-2-en-1-ol of formula (VII): n n n n n n n n n n in the presence of a palladium catalyst and a base, in a solvent selected from among N,N-dimethylformamide, polar protic and non-polar organic solvents, and at a temperature ranging from 60° C. to 150° C., and then conducting an amino reduction by reacting the 3-[4-(1,1-dimethyl-propyl)-phenyl]-2-methyl-propionaldehyde of formula (II) with cis-2,6-dimethyl morpholine of formula (IV): n n n n n n n n n n in the presence of a reducing agent and in a solvent.

专利号:US-7151112-B1
优先权日:2001-09-04
标题:Pharmaceutical uses and synthesis of nicotinamides
发明人：CUTSHALL NEIL S; JEFFREY SCOTT C
权利人:UCB SA
摘要:This invention is directed to methods of using a compound of the formula n nand pharmaceutically acceptable salts thereof, wherein n, X, R 1 and R 2 are disclosed herein, for treating inflammatory events in an animal subject.

专利号:WO-0009116-A1
优先权日:1998-08-14
标 题:Grp receptor ligands
发明人：XIANG JIA-NING; KARPINSKI JOSEPH M; CHRISTENSEN SIEGFRIED B IV
权利人:SMITHKLINE BEECHAM CORP; XIANG JIA NING; KARPINSKI JOSEPH M; CHRISTENSEN SIEGFRIED B IV
摘要:Novel GRP receptor antagonists are provided. Methods of using the present compounds to antagonize GRP receptors are also provided. The present invention further involves the synthesis of the present compounds.

专利号:US-8679724-B2
优先权日:2005-12-09
标题 :Positive resist composition, resin used for the positive resist composition, compound used for synthesis of the resin and pattern forming method using the positive resist composition