2-乙氧基-3,3-二甲基丁-1-烯置于臭氧体系中,用 吡啶,二氯甲烷 作为反应溶剂,以70%的收率获得产物三甲基乙酸乙酯 参考文献:Action De L'Ozone Sur Des Derives Vinyliques; Reactions Conservant L'Enchainement Carbone. 标题:Action De L'Ozone Sur Des Derives Vinyliques; Reactions Conservant L'Enchainement Carbone. 摘要: DOI:10.1016/s0040-4039(01)85544-1
专利号:US-2023303611-A1 优先权日:2022-01-21 标题:Synthesis of an antiviral azasugar triphosphate 发明人:KOTIAN PRAVIN L; Dang zhao; WU MINWAN 权利人:BIOCRYST PHARM INC 摘要:Provided are methods of making the active 5′-triphosphate form of galidesivir (compound 1) and the active 5′-triphosphate form of azasugar nucleoside analogues (compound 2):a potent anti-viral compound useful for broad spectrum treatment, suppression, and prevention of viral infections. The syntheses of compound 1 and compound 2 can be achieved via selective formation of protected intermediate 1b and protected intermediate 2b, respectively:
专利号:US-2004110228-A1 优先权日:2002-04-01 标 题:Combinatorial organic synthesis of unique biologically active compounds 发明人:MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M 摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.
专利号:EP-2097079-B1 优先权日:2006-11-30 标题:Modulation of prostaglandin/cyclooxygenase metabolic pathways 发明人:WUELFERT ERNST 权利人:HUNTER FLEMING LTD 摘要:A variety of diseases and disorders associated with the metabolic pathways involved in the activities of cyclooxygenase and the synthesis of prostaglandins, for example type 2 diabetes mellitus and its sequelae, ischemic vascular diseases, pain associated with inflammation, inflammatory skin conditions, spinal cord injury, peripheral neuropathy, multiple sclerosis, inflammatory bowel disease and rheumatoid arthritis, as well as various types of cancer may be treated or prevented by the use of an agent which selectively enhances production of 15-deoxy-prostaglandin J2. The compounds are 7-hydroxy-steroids or condensed indoles.
专利号:US-5783577-A 优先权日:1995-09-15 标题 :Synthesis of quinazolinone libraries and derivatives thereof 发明人:HOUGHTEN RICHARD A; OSTRESH JOHN M 权利人:TREGA BIOSCIENCES INC 摘要:The present invention provides synthetic combinatorial libraries of organic compounds based on the quinazolinone ring.
专利号:US-10974236-B2 优先权日:2016-11-10 标 题 :Use of ruthenium complexes in olefin metathesis reaction 发明人:SKOWERSKI KRZYSZTOF; GAWIN RAFAL; CHWALBA MICHAL PAWEL 权利人:APEIRON SYNTHESIS SA 摘要:The invention relates to the use of ruthenium complexes, which are homogeneous catalysts and/or precatalysts of the olefin metathesis reaction, which lead to the production of alkenes containing an internal (non-terminal) double Câ•?C bond.
专利号:WO-9710221-A1 优先权日:1995-09-15 标 题:Synthesis of quinazolinone libraries 发明人:HOUGHTEN RICHARD A; OSTRESH JOHN M 权利人:TORREY PINES INST 摘要:The present invention provides synthetic combinatorial libraries of organic compounds based on the quinazolinone ring.
[参考文献]: E Akaho, Et Al. Solubility Behavior Of Phenolic Compounds In Hexane-Ethyl Acetate, Hexane-Ethyl Myristate, And Hexane-Ethyl Pivalate Cosolvent Systems. J Pharm Sci. 1981 Nov;70(11):1225-8. [参考文献]: Yulia Kaluzhny, Et Al. The Epiocular Eye Irritation Test (Eit) For Hazard Identification And Labelling Of Eye Irritating Chemicals: Protocol Optimisation For Solid Materials And The Results After Extended Shipment. Altern Lab Anim. 2015 May;43(2):101-27.
合成参考文献
摘要:Petasis, N. A., Science of Synthesis, (2010) 47, 183. 摘要:Petasis, N. A., Science of Synthesis, (2010) 47, 195.