专利号:US-2003162992-A1 优先权日:2001-12-14 标 题 :Preparation of intermediates useful in the synthesis of antiviral nucleosides 发明人:WATANABE KYOICHI A; DU JINFA 摘要:The present invention is an efficient process for the manufacture of α-acyloxyacetaldehyde, a key intermediate in the synthesis of 1,3-oxathiolane and 1,3-dioxolane nucleosides.
专利号:US-7122693-B2 优先权日:1988-04-11 标题 :Acetaldehyde acetal compounds, their synthesis, and uses thereof 发明人:BELLEAU EXECUTRIX OF ESTATE PI; DIXIT DILIP M; NGUYEN-BA NGHE 权利人:SHIRE BIOCHEM INC 摘要:The acetaldehyde compounds, 2-thiobenzoylacetaldehyde diethylacetal, 2-benzoyloxyacetaldehyde bis(2-methoxyethyl)acetal, 2-hydroxyacetaldehyde bis( 2-methoxyethyl)acetal, 2-thiobenzoylacetaldehyde bis(2-methoxy-ethyl)acetal, and 2-thioacetaldehyde bis(2-methoxyethyl)acetal, are useful as intermediates in the synthesis of substituted 1,3-oxathiolanes and substituted 1,3-dioxolanes.
专利号:US-8304540-B2 优先权日:2007-05-18 标题:Process for stereoselective synthesis of lamivudine 发明人:LI JINLIANG; LV FENG 权利人:LI JINLIANG; LV FENG; SHANGHAI DESANO PHARMACEUTICAL HOLDING CO LTD 摘要:The present invention discloses a process for stereoselective synthesis of Lamivudine comprising the following steps: (a) performing a glycosylation reaction between the compound of formula (I) and cytosine or protected cytosine, and separating the reaction product by recrystallization to obtain the intermediate of formula (II); and (b) deprotecting the intermediate of formula (II) to obtain Lamivudine.
专利号:US-6143748-A 优先权日:1995-03-31 标题:Process for synthesis of nucleoside analogues 发明人:SAMANO MIRNA C; SAMANO VICENTE; GOODYEAR MICHAEL DAVID 权利人:GLAXO WELLCOME INC 摘要:The present invention is concerned with a process for the preparation of antiviral 1,3-oxathiolane nucleosides comprising an intramolecular glycosylation reaction to produce exclusively the β-diastereomer, and intermediates useful in the process.
专利号:US-8748604-B2 优先权日:2010-03-04 标 题 :Process for stereoselective synthesis of 5-fluoro-1-(2R,5S)-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine 发明人:KSHIRSAGAR PRAKASH BHIMAJI; BHOGE SATISH MANOHAR; RICHHARIYA SANTOSH; SINGH KAPTAN 权利人:KSHIRSAGAR PRAKASH BHIMAJI; BHOGE SATISH MANOHAR; RICHHARIYA SANTOSH; SINGH KAPTAN; RANBAXY LAB LTD 摘要:The present invention provides an improved process for stereoselective preparation of 5-fluoro-1-(2R,5S)-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine and pharmaceutically acceptable salts thereof.
专利号:US-8034895-B2 优先权日:2004-02-04 标题 :Conjugated thiophenes having conducting properties and synthesis of same 发明人:SKENE WILLIAM G 权利人:UNIV MONTREAL 摘要:The present invention relates to conjugated oligomers and polymers comprising aromatic thiophene cores. The conjugated materials are obtained by simple and efficient condensation of an aryl diamine and an aryl dialdehyde or a bifunctional aryl moiety comprising both an aldehyde and an amine. Condensation of the complementary moieties at temperatures ranging from ambient to refluxing temperatures in various solvents resulted in conjugated oligomers and polymers that can subsequently be cast into thin films. Oligomerization and polymerization can be done under mild conditions with removal of the resulting water bi-product responsible for shifting the equilibrium in favor of the conjugated products. The resulting conjugated compounds can be made conducting with dopants affording electrically conducting materials of either p-type or n-type conductors depending on the dopant selected.
参考标题:I2-Promoted Povarov-Type Reaction Using 1,4-Dithane-2,5-Diol As An Ethylene Surrogate: Formal [4 + 2] Synthesis Of Quinolines 作者:Xia Wu,Xiao Geng,Peng Zhao,Jingjing Zhang,Xingxing Gong,Yan-Dong Wu,An-Xin Wu |发布日期:2017.4.7 摘要:Developed For The Synthesis Of 2-Acylquinolines From Methyl Ketones And Arylamines Using 1,4-Dithane-2,5-Diol As An Ethylene Surrogate. Moreover, The Investigation Of The Mechanism Suggested That This Reaction Occurred Via An Iodination/kornblum Oxidation/povarov/aromatization Sequence. It Is Noteworthy That The Arylamine Substrate Also Played An Important Role In Promoting The Reaction.
合成参考文献
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