CAS: 4156-16-5; 2-Ethyl-5-Phenylisoxazolium-3-Sulfonate

相似化合物

13567-19-6 5765-40-2 5765-41-3

5-苯基异噁唑置于盐酸体系中,用 乙醇 作为反应溶剂,化学反应 3.0H,反应生成 伍德沃德氏试剂k
参考文献:有用的肽合成
标题:有用的肽合成
摘要:羧酸盐在非常温和的条件下与3-未取代的异恶唑鎓盐快速平稳地反应,反应生成烯醇酯.在本文中,我们报告了该反应作为简单而实用的肽合成中的羧基活化步骤的应用.详细描述了特定的肽形成试剂n-乙基-5-苯基异恶唑-3'-磺酸盐的用途.
DOI:10.1016/s0040-4020(01)82192-X

专利信息

专利号:US-5883221-A
优先权日:1996-11-12
标题:Synthesis of polybenzoxasole and polybenzothiazole precursors
发明人：SEZI RECAI; KUEHN EBERHARD; AHNE HELLMUT; KOCMAN SUELEYMAN
权利人:SIEMENS AG
摘要:In a method of synthesis of polybenzoxazole and polybenzothiazole precursors, a dicarboxylic acid or a dicarboxylaic acid ester is reacted with a bis-o-aminophenol or bis-o-aminothiophenol in a suitable solvent in the presence of an activating reagent having the following structure: ##STR1##

专利号:US-2008145899-A1
优先权日:2004-09-17
标题 :Production of Oligosaccharides By Microorganisms
发明人：JOHNSON KARL; BYRNE NOEL J; DEFREES SHAWN
权利人:NEOSE TECHNOLOGIES INC
摘要:The present invention relates to the enzymatic synthesis of oligosaccharides, including sialylated product saccharides. In particular, it relates to the use of recombinant cells to take up low cost precursors such as glucose, pyruvate and N-actyl-glucosamine, and to synthesize activated sugar moieties that are used in oligosaccharide synthesis. The methods make possible the synthesis of many oligosaccharides using microorganisms and readily available, relatively inexpensive starting materials.

专利号:US-7329760-B2
优先权日:2002-04-05
标题 :CC-1065 analog synthesis
发明人：ZHAO ROBERT YONGXIN; CHARI RAVI V J
权利人:IMMUNOGEN INC
摘要:Improved synthesis of seco(−)CBI (5-hydroxy-3-amino-1-[S]-(chloromethyl)-1,2-dihydro-3H-benz(e)indole): n nand improved syntheses therefrom of a wide variety of CC-1065 analogs that comprise a cyclopropabenzidole (CBI) alkylating moiety, and which are collectively DC1 and its derivatives, for the synthesis of cell-targeted therapeutic agents.

专利号:WO-2025088147-A1
优先权日:2023-10-27
标题 :Theranostic psma-targeting ligands for the diagnosis and treatment of psma-expressing cancers and their solid phase synthesis
发明人：Schäfer Martin; BAUDER-WUEST ULRIKE; ROSCHER MAREIKE; REMDE YVONNE; BENEÅ OVÃ?-SCHÄFER MARTINA; BARINKA CYRIL; KUTILOVÃ? ZSÓFIA; MOTLOVÃ? LUCIA
权利人:DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES OEFFENTLICHEN RECHTS
摘要:The present invention generally relates to the field of radiopharmaceuticals and their use in nuclear medicine as tracers, imaging agents and radiopharmaceuticals for the treatment of various disease states of PSMA-expressing cancers, especially prostate cancer, and metastases thereof. Further the present invention provides synthetic procedures for the synthesis of such PSMA-targeting ligands.

专利号:US-6077962-A
优先权日:1998-12-24
标题 :N-3, 3-dimethylbutyl-L-aspartic acid and esters thereof, the process of preparing the same, and the process for preparing N-(N-(3,3-dimethylbutyl) -α L-aspartyl)-L- phenylalanine 1-methyl ester therefrom
发明人：PRAKASH INDRA; CHAPEAU MARIE-CHRISTINE D
权利人:NUTRASWEET CO
摘要:This invention relates to the chemical synthesis of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester using peptide coupling methods. The coupling reaction is conducted by condensation of an activated derivative of novel N-neohexyl-L-aspartic acid with L-phenylalanine or L-phenylalanine methyl ester or by enzymatic coupling of N-neohexyl-L-aspartic acid with L-phenylalanine or L-phenylalanine methyl ester. This invention also relates to novel N-(3,3-dimethylbutyl)-L-aspartic acid, derivatives thereof and the preparation thereof. The activated derivative of N-neohexyl-L-aspartic acid may be an anhydride, mixed anhydride, active ester or an intermediate activated derivative thereof.

专利号:US-5215997-A
优先权日:1985-09-11
标题:Synthesis of beta-lactam compounds
发明人：HUNGERBUEHLER ERNST; KALVODA JAROSLAV
权利人:CIBA GEIGY CORP
摘要:The invention relates to an improved process for the preparation of compounds of formula ##STR1## or salts thereof, starting from compounds of formulae ##STR2## via compounds of formulae ##STR3## in which compounds R 1 is hydrogen or lower alkyl, R 2 is an organic radical which may carry a functional group which may be protected by a customary protective group R 2 o , R 3 is hydrogen or a customary carboxyl protective group R 3 o , W is a group which can be replaced by a thiocarboxylic acid radical of formula III, and Z is oxygen or sulfur.