CAS: 63593-03-3; ((3Ar,6S,6Ar)-6-(Benzyloxy)-2,2-Dimethyltetrahydrofuro[2,3-D][1,3]Dioxole-5,5-Diyl)Dimethanol

相似化合物

72261-44-0 153186-10-8 206055-83-6

上下游产品

CAS号50-00-0 甲醛 | CAS号63593-02-2 3-O-benzyl-1,2-... | CAS号620630-82-2 4-[2-(4-methoxy... | CAS号22331-21-1 3-O-苄基-1,2:5,6-... | CAS号2595-05-3 1,2:5,6-双-O-异丙叉... | CAS号100-39-0 溴化苄 | CAS号221229-65-8 4-(甲基磺酰氧甲基)-1,2... | CAS号200435-92-3 1-(2’-O,4-C-甲桥-... | CAS号206055-67-6 1-(2’-O,4-C-甲桥-...

D-Glucose置于sodium Hypochlorite,Sodium Tetrahydroborate,Sodium Periodate,2,2,6,6-四甲基哌啶氧化物,磷酸,四丁基硫酸氢铵,碳酸氢钠,溶剂黄146,Potassium Bromide,Sodium Hydroxide,Zinc(II) Chloride体系中,用 四氢呋喃,1,4-二氧六环,水,乙酸乙酯,甲苯 作为反应溶剂,化学反应 22.33H,反应生成 3-O-苄基-4-C-羟甲基-1,2-O-异亚丙基-Alpha-D-呋喃核糖
参考文献: Novel Process For Making Allofuranose From Glucofuranose[fr] Nouveau Procédé De Fabrication D'Allofuranose à Partir De Glucofuranose
标题: Novel Process For Making Allofuranose From Glucofuranose[fr] Nouveau Procédé De Fabrication D'Allofuranose à Partir De Glucofuranose
摘要:本发明涉及从描述和权利要求中定义的葡糖呋喃糖中制备阿洛呋喃糖.阿洛呋喃糖是合成寡核苷酸时的中间体,可用作药物.

专利信息

专利号:US-6639059-B1
优先权日:1999-03-24
标 题 :Synthesis of [2.2.1]bicyclo nucleosides
发明人：KOCHKINE ALEXEI; FENSHOLDT JEF; PFUNDHELLER HENRIK M
权利人:EXIQON AS
摘要:A synthesis of [2.2.1]bicyclo nucleosides which is shorter and provides higher overall yields proceeds via the key intermediate of the general formula III, wherein R4 and R5 are, for instance, sulfonates and R7 is, for instance, a halogen or an acetate. From compounds of the general formula II, such as 3-O-aryl-4-C-hydroxymethyl-1,2-O-isopropylidene-alpha-D-ribofuranose, intermediates of the general formula III are suitable for coupling with silylated nucleobases. Upon one-pot base-induced ring-closure and desulfonation of the formed [2.2.1]bicyclo nucleoside, a short route to each the LNA (Locked Nucleic Acid) derivatives of adenosine, cytosine, uridine, thymidine and guanidine is demonstrated. The use of the 5'-sulfonated ring-closed intermediate also allows for synthesis of 5'-amino- and thio-LNAs.

专利号:US-6734291-B2
优先权日:1999-03-24
标题:Synthesis of [2.2.1]bicyclo nucleosides
发明人：KOCHKINE ALEXEI; FENSHOLDT JEF; PFUNDHELLER HENRIK M
权利人:EXIQON AS
摘要:A synthesis of [2.2.1]bicyclo nucleosides which is shorter and provides higher overall yields proceeds via the key intermediate of the general formula III, wherein R4 and R5 are, for instance, sulfonates and R7 is, for instance, a halogen or an acetate. From compounds of the general formula II, such as 3-O-aryl-4-C-hydroxymethyl-1,2-O-isopropylidene-alpha-D-ribofuranose, intermediates of the general formula III are suitable for coupling with silylated nucleobases. Upon one-pot base-induced ring-closure and desulfonation of the formed [2.2.1]bicyclo nucleoside, a short route to each the LNA (Locked Nucleic Acid) derivatives of adenosine, cytosine, uridine, thymidine and guanidine is demonstrated. The use of the 5'-sulfonated ring-closed intermediate also allows for synthesis of 5'-amino- and thio-LNAs

专利号:US-2003092905-A1
优先权日:1999-03-24
标 题:Synthesis of [2.2.1]bicyclo nucleosides

专利号:WO-0056746-A2
优先权日:1999-03-24
标题 :Improved synthesis of [2.2.1]bicyclo nucleosides

专利号:US-9701682-B2
优先权日:2013-11-11
标题:Pyrrolo[1,2-f][1,2,4]triazines useful for treating respiratory syncitial virus infections
发明人：CLARKE MICHAEL O'NEIL HANRAHAN; DOERFFLER EDWARD; MACKMAN RICHARD L; SIEGEL DUSTIN
权利人:GILEAD SCIENCES INC
摘要:Provided herein are formulations, methods and substituted tetrahydrofuranyl-pyrrolo[1,2-f][1,2,4]triazine-4-amine compounds of Formula (I) for treating Pneumovirinae virus infections, including respiratory syncytial virus infections, as well as methods and intermediates for synthesis of tetrahydrofuranyl-pyrrolo[1,2-f][1,2,4]triazine-4-amine compounds.

专利号:JP-WO2020032152-A1
优先权日:2018-08-09
标题 :Stereoselective synthesis of 4'-substituted nucleoside derivatives