CAS: 63699-78-5; Glupa-Carboxylate Monoammonium

英文名称Glupa-Carboxylate Monoammonium
中文名称L-谷氨酸-5-(3-羧基-4-硝基苯胺)铵盐
IUPAC名称ammonium (S)-5-(4-amino-4-carboxybutanamido)-2-nitrobenzoate
其它别名Benzoic Acid,5-[(4-Amino-4-Carboxy-1-Oxobutyl)Amino]-2-Nitro-, Monoammonium Salt, (S)- (9Ci); -2-Nitrobenzoate; -5-(4-Amino-4-Carboxybutanamido); Ammonium (S); L-Glutamic Acid γ-(3-Carboxy-4-Nitroanilide); H-Gla(Pna)-Oh; H-Gla(Pna)-Oh Nh3; H-Glu(3-Carboxy-Pna)-Oh
CAS编号63699-78-5
MFCD编号:MFCD00058243
EINECS号:264-418-7
分子式:C12H16N4O7
分子量:328.28
产品CID: 1618846
产品分类生物化工 → 氨基酸及其衍生物 → 谷氨酸类衍生物

相似结构搜索
InChIKey: GFABNNMTRVBLPZ-QRPNPIFTSA-N
InChI=1/C12H13N3O7.H3N/c13-8(12(19)20)2-4-10(16)14-6-1-3-9(15(21)22)7(5-6)11(17)18;/h1,3,5,8H,2,4,13H2,(H,14,16)(H,17,18)(H,19,20);1H3/t8-;/…
计算化学: 氢键受体数8.0氢键供体数4.0可旋转键数5.0

MSDS等安全信息

GHS符号GHS06
警示词Danger
危险描述H301-H311-H331
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P310-P330-P361-P403+P233-P405-P501
UN编号NONH for all modes of transport
安全声明22-24/25
WGK Germany3

合成工艺路线路线简述

(S)-5-(4-Carboxy-4-(1,3-Dioxoisoindolin-2-yl)Butylamido)-2-Nitrobenzoic Acid置于hydrazine Hydrate体系中,用乙腈作为反应溶剂,以67%的收率获得产物l-谷氨酸γ-(3-甲酸-4硝基苯胺)铵盐
参考文献:一种转肽酶生化检验试剂底物的制备方法
标题:一种转肽酶生化检验试剂底物的制备方法
摘要:本发明涉及一种转肽酶生化检验试剂底物的制备方法,属于化学合成的技术领域,制备方法以5‑氨基‑2‑硝基苯甲酸与化合物a邻苯二甲酰‑l‑谷氨酸酐为起始原料,具体包括以下步骤:步骤(1):5‑氨基‑2‑硝基苯甲酸与化合物a邻苯二甲酰‑l‑谷氨酸酐在酸性溶剂中反应合成中间体b;步骤(2):在溶剂中,将所述中间体b和水合肼进行如下所示的反应,在离子交换树脂作用下铵根化得到化合物glupa‑c,本发明的制备方法对γ‑谷氨酰‑3‑羧基‑4‑硝基苯胺单铵盐的制备工艺,反应条件和方法进行了改进和优化,使得产品的产率和纯度得到大幅度提高,且制备工艺简便安全,易于放大,适合于工业生产.

海关参考信息

2905121000-正丙醇
2905130000-正丁醇
2906210000-苄醇
2912110000-甲醛
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详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-2025195678-A1
优先权日:2019-10-15
标题:B-lymphocyte specific amatoxin antibody conjugates
发明人：HECHLER TORSTEN; PAHL ANDREAS; KULKE MICHAEL; MÃ¼LLER CHRISTOPH
权利人:HEIDELBERG PHARMA RES GMBH
摘要:The present application relates to a conjugate comprising an amatoxin, a target-binding moiety wherein the target is CD20, i.e., a CD20-binding moiety, and optionally a linker linking said amatoxin and said CD20-binding moiety. The invention further relates to the synthesis of said conjugate. In addition, the invention relates to a pharmaceutical composition comprising such conjugate, particularly for use in the treatment of B-cell and/or lymphoma associated diseases and/or malignancies.

专利号:CN-117430521-A
优先权日:2023-09-05
标题:A kind of synthesis method of L-Î³-glutamyl-3-carboxy-4-nitroaniline ammonium salt