CAS: 1034667-22-5; 5-Fluoro-1H-Pyrazolo[3,4-B]Pyridin-3-Amine

2,6-二氯-5-氟烟酸置于palladium Diacetate,N,N-二甲基甲酰胺,三苯基膦 甲酸,草酰氯,一水合肼,三乙胺,三氟乙酸酐体系中,用 二氯甲烷,N,N-二甲基甲酰胺,正丁醇 用作溶剂,化学反应 5.5H,反应生成3-氨基-5-氟-1H-吡唑[3,4-B]吡啶
参考文献:Aminopyrimidines Useful As Inhibitors Of Protein Kinases
标题:Aminopyrimidines Useful As Inhibitors Of Protein Kinases
摘要:本发明涉及用作蛋白激酶抑制剂的化合物.该发明还提供包含这些化合物的药用合适组合物,以及在治疗各种疾病,症状和障碍中使用这些化合物和组合物的方法.该发明还提供制备本发明化合物的方法.

专利信息

专利号:US-8598361-B2
优先权日:2007-07-31
标题 :Process for preparing 5-fluoro-1H-pyrazolo [3,4-B] pyridin-3-amine and derivatives therof
发明人：JIMENEZ JUAN-MIGUEL; MILLER ANDREW; COLLIER PHILIP; GREEN JEREMY; DROS ALBERT; GAO HUAI; HAMON SYLVAIN
权利人:JIMENEZ JUAN-MIGUEL; MILLER ANDREW; COLLIER PHILIP; GREEN JEREMY; DROS ALBERT; GAO HUAI; HAMON SYLVAIN; VERTEX PHARMA
摘要:The present invention relates to a process for the synthesis of 5-fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine in high yield and purity. The present invention also relates to processes for the synthesis of 5-fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine derivatives. These processes are useful for preparing biologically active compounds, particularly certain GSK-3 inhibitors, or derivatives thereof.

专利号:US-2013211090-A1
优先权日:2010-09-03
标题:Method for the production of 5-fluoro-1h-pyrazolo[3,4-b]pyridine-3-carbonitrile
发明人：FOLLMANN MARKUS; ACKERSTAFF JENS
权利人:FOLLMANN MARKUS; ACKERSTAFF JENS; BAYER IP GMBH
摘要:The present invention relates to a process for preparing 5-fluoro-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile of the formula (I) n n n n n n n n n n which serves as a synthesis intermediate for production of medicaments, especially for production of medicaments for treatment and/or prophylaxis of cardiovascular disorders.