CAS: 524-36-7; 4-(Aminomethyl)-5-(Hydroxymethyl)-2-Methylpyridin-3-Ol Dihydrochloride

结构式图片

相似化合物

58-56-0 58-56-0 148-51-6

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号408335-89-7 2-methyl-3-hydr... | CAS号863030-57-3 (5-acetoxy-4-((... | CAS号20905-66-2 2-Methyl-3-hydr... | CAS号58-56-0 吡哆醇盐酸盐 | CAS号529-96-4 吡哆胺5 '磷酸盐 | CAS号58-56-0 吡哆醇盐酸盐 | CAS号54-47-7 磷酸吡哆醛 | CAS号97994-72-4 4-(aminomethyl)...

合成工艺路线路线简述

  • 合成目标产物 Pyridoxamine Dihydrochloride 主要起始原料 408335-89-7
  • (文献来源)合成步骤主要原料 408335-89-7

海关参考信息

专利信息


专利号:US-10005720-B2
优先权日:2013-04-05
标题:Compounds useful for the treatment of metabolic disorders and synthesis of the same
发明人:SEXTON JONATHAN Z; BRENMAN JAY E; MUSSO DAVID L
权利人:NORTH CAROLINA CENTRAL UNIV; UNIV NORTH CAROLINA CHAPEL HILL
摘要:The present invention provides compounds of Formula (I): wherein variables X, Y, Z and R1 are as described herein. Some of the compounds described herein are glutamate dehydrogenase activators. The invention is also directed to pharmaceutical compositions comprising these compounds, uses of these compounds and compositions in the treatment of metabolic disorders as well as synthesis of the compounds.

专利号:US-8431712-B2
优先权日:2004-02-09
标 题 :Methods for the synthesis of pyridoxamine
发明人:KHALIFAH RAJA G; KEILITZ ROLAND; KOELLNER CHRISTOPH; DEGENHARDT THORSTEN; BRAND STEPHEN ROBERT
权利人:KHALIFAH RAJA G; KEILITZ ROLAND; KOELLNER CHRISTOPH; DEGENHARDT THORSTEN; BRAND STEPHEN ROBERT; NEPHROGENEX INC
摘要:The invention provides non-oxidative methods for the large scale manufacture of pyridoxamine (I) (4-aminomethyl-3-hydroxy-5-hydroxymethyl-2-methylpyridine): n nand salts thereof.n nThe invention also provides intermediate compounds for the synthesis of pyridoxamine, as well as compositions and methods for the treatment and/or prevention of conditions associated with the formation of post-Amadori advanced glycation end-products.

专利号:US-2016107992-A1
优先权日:2013-06-20
标 题:Intermediates useful for the preparation of saxagliptin
发明人:CASTALDI GRAZIANO; PALLANZA GIUSEPPE; GABOARDI MAURO; CASTALDI MARTA
权利人:CHEMELECTIVA S R L
摘要:Intermediates useful for the synthesis of saxagliptin and their preparationare described.

专利号:US-2018370905-A1
优先权日:2013-04-05
标题:Compounds Useful for the Treatment of Metabolic Disorders and Synthesis of the Same

专利号:US-7214799-B2
优先权日:2004-02-09
标题 :Methods for the synthesis of pyridoxamine

专利号:US-2007161678-A1
优先权日:2004-02-09
标题:Methods for the synthesis of pyridoxamine
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主要参考文献


1: Mori Y, Kakuta T, Miyakogawa T, Takekoshi S, Yuzawa H, Kobayashi H, Kawakami A, Miyata T, Fukagawa M. Effect of Scavenging Circulating Reactive Carbonyls by Oral Pyridoxamine in Uremic Rats on Peritoneal Dialysis. Ther Apher Dial. 2016 Sep 13. doi: 10.1111/1744-9987.12446. [Epub ahead of print] doi: 10.1371/journal.pone.0159666. eCollection 2016.
3: Assimos DG. Re: Pyridoxamine and Pyridoxal are More Effective than Pyridoxine in Rescuing Folding-Defective Variants of Human Alanine:Glyoxylate Aminotransferase Causing Primary Hyperoxaluria Type I. J Urol. 2016 Apr;195(4P1):1170-1. doi: 10.1016/j.juro.2016.01.066. Epub 2016 Jan 22. doi: 10.1016/j.foodchem.2016.05.106. Epub 2016 May 17. doi: 10.1152/ajprenal.00056.2016. Epub 2016 May 18.
6: Ren X, Sun H, Zhang C, Li C, Wang J, Shen J, Yu D, Kong L. Protective function of pyridoxamine on retinal photoreceptor cells via activation of the p Erk1/2/Nrf2/Trx/ASK1 signalling pathway in diabetic mice. Mol Med Rep. 2016 Jul;14(1):420-4. doi: 10.3892/mmr.2016.5270. Epub 2016 May 13. doi: 10.1002/cmdc.201500552. Epub 2016 Feb 17. doi: 10.1002/1873-3468.12080. Epub 2016 Feb 15. doi: 10.2337/db15-1390. Epub 2015 Dec 30. doi: 10.1002/jsfa.7522. Epub 2015 Dec 16. doi: 10.1371/journal.pone.0136761. eCollection 2015.

合成参考文献


摘要:Arzneimittel-Forschung. Drug Research., 11(922), 1961 []
参考文献:10.1007/s002030050747
摘要:Neubauer H, Pantel I, Lindgren PE, Götz F. Characterization of the molybdate transport system ModABC of Staphylococcus carnosus. Arch Microbiol. 1999 Aug;172(2):109–15. doi: 10.1007/s002030050747.
参考文献:10.1007/s00216-020-02857-5
摘要:Bachmann T, Maurer A, Rychlik M. Development of a LC-MS/MS method using stable isotope dilution for the quantification of individual B6 vitamers in fruits, vegetables, and cereals. Analytical and Bioanalytical Chemistry. 2020 Aug 14;412(26):7237–52. doi: 10.1007/s00216-020-02857-5.
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