CAS: 537-73-5; 3-(3-Hydroxy-4-Methoxyphenyl)Acrylic Acid

该化合物是一种该化合物是一种纤维酸的结构性异构体,其特征是甲氧基组在芳香环上的位置;异硫酸表现出显著的抗氧化剂,抗炎剂和潜在的光保护性能,使其在制药和化妆应用中具有价值;已经研究过它是否有能力对自由基和调节炎症进行治疗;该化合物由于其特性结构精良,还被用作分析化学的参考标准;其稳定性和生物利用率进一步提高了其在研发中的效用.

结构式图片

欧盟法规

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上下游产品

CAS号621-59-0 异香兰素; 3-羟基-4-甲氧... | CAS号141-82-2 丙二酸 | CAS号84428-15-9 Ethyl 3-(3-Hydr... | CAS号645386-79-4 isoferulic acid... | CAS号58435-27-1 3-amino-4-metho... | CAS号97966-29-5 异阿魏酸甲酯 | CAS号520-26-3 橙皮苷 | CAS号58435-22-6 4-METHOXY-3-NIT... | CAS号139-85-5 原儿茶醛; 原二茶醛; 茶酚甲... | CAS号64-19-7 冰醋酸 | CAS号99-50-3 原儿茶酸 | CAS号64-19-7 冰醋酸 | CAS号5396-64-5 3-(3',4'-二甲氧基苯基)丙酸甲酯 | CAS号1135-15-5 3-羟基-4-甲氧基苯基丙酸 | CAS号129150-61-4 3-(3-羟基-4-甲氧基苯基)丙酸甲酯 | CAS号16980-82-8 3-(3-羟基-4-甲氧基苯基... | CAS号653579-84-1 1-diazonio-4-(4... | CAS号56772-00-0 3,3',4,4',5,5'-... | CAS号6305-53-9 Benzenepropanoi...

合成工艺路线路线简述

    橙皮甙置于barium Dihydroxide体系中,化学反应生成 3-羟基-4-甲氧基肉桂酸
    参考文献:Asahina; Inubuse,Yakugaku Zasshi/journal Of The Pharmaceutical Society Of Japan,1929,Vol. 49,P. 11
    标题:Asahina; Inubuse,Yakugaku Zasshi/journal Of The Pharmaceutical Society Of Japan,1929,Vol. 49,P. 11

    海关参考信息

    专利信息


    专利号:US-12240808-B2
    优先权日:2021-05-28
    标 题 :Process for the synthesis of calebin-a and its intermediates
    发明人:MAJEED MUHAMMED; NAGABHUSHANAM KALYANAM; MUTHUKAMAN NAGARAJAN; NAIDU PENTAKOTA PARADESI
    权利人:MAJEED MUHAMMED; NAGABHUSHANAM KALYANAM; MUTHUKAMAN NAGARAJAN; NAIDU PENTAKOTA PARADESI
    摘要:The invention discloses novel intermediates in the synthesis of Calebin A represented by formula 3. The invention also covers processes for the synthesis of Calebin-A and its analogs using compounds of formula 3.

    专利号:US-8647848-B2
    优先权日:2008-06-13
    标题:Enzymatic synthesis of sphingolipids
    发明人:HOLLMANN FRANK; THUM OLIVER; TOELLE CHRISTOPH; PROVINZANO ANGELO; KOREVAAR CORNELIS GERRIT NIJS
    权利人:HOLLMANN FRANK; THUM OLIVER; TOELLE CHRISTOPH; PROVINZANO ANGELO; KOREVAAR CORNELIS GERRIT NIJS; EVONIK GOLDSCHMIDT GMBH
    摘要:The invention relates to the enzymatic synthesis of sphingolipids and compositions that contain sphingolipids from lysosphingolipids and carbonic esters, and to cosmetic, dermatological or pharmaceutical formulations containing said sphingolipids or compositions.

    专利号:US-7700654-B2
    优先权日:2005-02-05
    标 题:Isolation of N-butylbenzenesulfonamide, synthesis of benzenesulfonamide derivatives, and use of N-butylbenzenesulfonamide and benzenesulfonamide derivatives for treating benign prostatic hyperplasia and/or prostate carcinoma
    发明人:HOFFMANN HANS-RAINER; MATUSCH RUDOLF; BANIAHMAD ARIA
    权利人:LOHMANN THERAPIE SYST LTS
    摘要:A process for isolating N-butylbenzenesulfonamide (NBBS) from biological material, the chemical synthesis of benzenesulfonamide derivatives, the use of NBBS and benzenesulfonamide derivatives for treating benign prostatic hyperplasia and/or prostate carcinoma, the production of medicaments for the treatment thereof, and the use of NBBS and benzenesulfonamide derivatives as a lead substance in the development of active substances for treating benign prostatic hyperplasia and/or prostate carcinoma are provided.

    专利号:US-10604479-B2
    优先权日:2013-11-18
    标 题:Continuous process for the one-pot synthesis of metal salts and metal complexes
    发明人:LEONARDI GIULIANO; GASPERONI GIOVANNI
    权利人:VOLARE & CONNECTING LLC; LEONARDI GIULIANO; NOVUS INT INC
    摘要:A continuous process is described for the one-pot synthesis of compounds, such as metal salts and metal complexes, as well as optionally for the protection of the compounds thus obtained by coating and/or impregnation with suitable compounds.

    专利号:US-8420850-B2
    优先权日:2010-05-14
    标 题:Compounds for the synthesis of biostable polyurethane, polyurea or polyurea urethane polymers
    发明人:DUOCASTELLA CODINA LLUIS; MOLINA MARIA; ARAD OFIR; BORRELL BILBAO JOSE IGNACIO; GARCIA DAVID SANCHEZ; PETTERSON SALOM SOFIA HENRIETTE
    权利人:DUOCASTELLA CODINA LLUIS; MOLINA MARIA; ARAD OFIR; BORRELL BILBAO JOSE IGNACIO; GARCIA DAVID SANCHEZ; PETTERSON SALOM SOFIA HENRIETTE; IBERHOSPITEX SA
    摘要:The invention comprises compounds which are derived from a drug or a substance with therapeutic properties, and useful as reagents for the synthesis of biostable polymers including said drug in their backbone, namely polyurethanes, polyureas or polyurea urethanes that are biocompatible and biostable. The invention also comprises the processes for preparing the compounds and the polymers, and to the use of these polymers for the manufacture of medical devices.

    专利号:US-11384367-B2
    优先权日:2016-12-22
    标题:Synthesis of bioproducts from lignin-derived aromatics by genetically modified microorganisms
    发明人:GLADDEN JOHN M; SKERKER JEFFREY M; KEASLING JAY D; KIRBY JAMES; YAEGASHI JUNKO
    权利人:UNIV CALIFORNIA; NAT TECH & ENG SOLUTIONS SANDIA LLC; BATTELLE MEMORIAL INSTITUTE FOR MANAGEMENT AND OPERATION OF PACIFIC NORTHWEST NAT LABORATORY; NATIONAL TECH AND ENGINEERING SOLUTIONS OF SANDIA LLC
    摘要:The present invention provides for a method of converting a depolymerized lignin aromatic compound into a bioproduct, comprising: (a) providing a composition comprising a depolymerized lignin aromatic compound, optionally a depolymerized cellulose, and optionally a depolymerized hemicellulose, and (b) introducing a genetically modified microorganism to the composition, wherein the genetically modified microorganism is capable of converting the depolymerized lignin aromatic compound into a bioproduct; such that the depolymerized lignin aromatic compound is converted into a bioproduct.
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    主要参考文献

    [参考文献]: Liu Im, Et Al. Mediation Of Beta-Endorphin By Isoferulic Acid To Lower Plasma Glucose In Streptozotocin-Induced Diabetic Rats. J Pharmacol Exp Ther. 2003 Dec;307(3):1196-204.
    [参考文献]: Sakai S, Et Al. Administration Of Isoferulic Acid Improved The Survival Rate Of Lethal Influenza Virus Pneumonia In Mice. Mediators Inflamm. 2001 Apr;10(2):93-6.
    [参考文献]: Anastasia Karioti, Et Al. Identification Of Tyrosinase Inhibitors From Marrubium Velutinum And Marrubium Cylleneum. Bioorg Med Chem. 2007 Apr 1;15(7):2708-14.
    [参考文献]: Andreas R Rechner, Et Al. The Metabolism Of Dietary Polyphenols And The Relevance To Circulating Levels Of Conjugated Metabolites. Free Radic Res. 2002 Nov;36(11):1229-41.
    [参考文献]: Kevin Guo, Et Al. Ion-Pairing Reversed-Phase Liquid Chromatography Fractionation In Combination With Isotope Labeling Reversed-Phase Liquid Chromatography-Mass Spectrometry For Comprehensive Metabolome Profiling. J Chromatogr A. 2011 Jun 10;1218(23):3689-94.

    合成参考文献


    参考文献:10.1016/j.phymed.2005.06.007
    摘要:Jiang B, Kronenberg F, Balick MJ, Kennelly EJ. Analysis of formononetin from black cohosh (Actaea racemosa). Phytomedicine. 2006 Jul;13(7):477–86. doi: 10.1016/j.phymed.2005.06.007.
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