CAS: 5500-21-0; Cyclopropanecarbonitrile

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1489-69-6 1759-53-1 6228-73-5

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CAS号628-20-6 4-氯丁腈 | CAS号107-13-1 丙烯腈 | CAS号74-95-3 二溴甲烷 | CAS号5332-06-9 4-溴丁腈 | CAS号6228-73-5 环丙酰胺 | CAS号77100-86-8 2,4-dichlorobut... | CAS号58644-53-4 环丙基异腈 | CAS号25354-42-1 三氟甲烷磺酸环丙酯 | CAS号66997-38-4 tributylhexadec... | CAS号7664-41-7 氨 | CAS号39615-34-4 环丙基2-甲基苯基酮 | CAS号38675-82-0 3-三氟甲基苯基环丙基甲基酮 | CAS号14113-94-1 1-环丙基-2-苯基乙酮 | CAS号14113-96-3 1,2-二环丙基乙酮 | CAS号51285-13-3 环丙甲酰胺肟 | CAS号150322-73-9 1-环丙基-2-(2-氟苯基)乙酮 | CAS号95-52-3 邻氟甲苯 | CAS号446-51-5 2-氟苄醇 | CAS号141-97-9 乙酰乙酸乙酯 | CAS号77570-31-1 3-amino-3-cyclo...

1-氰基-1-环丙烷羧酸 以 水 作为反应溶剂,以85.8%的收率获得产物环丙基腈
参考文献:一种合成环丙氨的新方法和工艺
标题:一种合成环丙氨的新方法和工艺
摘要:本发明公开了一种环丙氨合成路线合成工艺路线,该工艺路线中,先以氰基乙酸酯和二氯乙烷为起始原料,通过环化反应生成1‑氰基环丙烷‑1‑甲酸酯(1),(1)在强碱的作用下水解反应生成1‑氰基环丙烷‑1‑甲酸(2),(2)脱羧反应生成环丙基氰(3),(3)在强碱的作用下反应生成环丙烷甲酰胺(4),(4)经过霍夫曼重排得到目标产物环丙氨.本工艺路线虽然较现阶段生产工艺,反应路线长,但避免了高温高压的使用,降低了危险性,提高了安全性,降低了对反应设备的要求,所使用的原料易得,易于操作,安全环保,可以实现工业化生产.

专利信息

专利号:US-9085538-B2
优先权日:2010-07-26
标题:Process for the preparation of key intermediates for the synthesis of statins or pharmaceutically acceptable salts thereof
发明人：CASAR ZDENKO; STERK DAMJAN; JUKIC MARKO
权利人:CASAR ZDENKO; STERK DAMJAN; JUKIC MARKO; LEK PHARMACEUTICALS
摘要:The invention relates to commercially viable process for the synthesis of key intermediates for the preparation of statins, in particular Rosuvastatin and Pitavastatin or respective pharmaceutically acceptable salts thereof. A new simple and short synthetic route for key intermediates is presented which benefits from the use of cheap and readily available starting materials, by which the conventionally most frequently used DIBAL-H as reducing agent can be avoided.

专利号:US-9695169-B2
优先权日:2012-05-31
标 题:Synthesis of heterocyclic compounds
发明人：IBRAHIM PRABHA N
权利人:PLEXXIKON INC
摘要:Provided herein are intermediates and processes useful for facile synthesis of biologically active molecules.

专利号:US-2025034146-A1
优先权日:2023-07-13
标题:Electro-photochemical synthesis of 1,2,4-triazolo-[4,3-a]pyrazine
发明人：PIERCEY DAVIN GLENN; YOUNT JOSEPH ROBERT
权利人:PURDUE RESEARCH FOUNDATION
摘要:A method of preparing a 1,2,4-triazolo-[4,3-a]pyrazine backbone using an electro-photochemical process comprising coupling a compound comprising a 5-substituted tetrazole moiety to a compound comprising an optionally substituted pyrazine moiety electrochemically and subjecting the resulting compound to photochemical excitation with ultraviolet light.

专利号:US-4264527-A
优先权日:1979-08-01
标 题:Process for the preparation of cyclopropylmethyl-n-propylamine
发明人：CURTIS EDWYN A
权利人:CIBA GEIGY CORP
摘要:A process for preparing cyclopropylmethyl-n-propylamine from the reaction of cyclopropylmethylamine with propionitrile is described. The reaction takes place in the presence of a hydrogenation catalyst, preferably a mixture of rhodium on carbon and platinum on carbon. The process is particularly useful as it consumes the cyclopropylmethylamine by-product from another scheme for the synthesis of cyclopropylmethyl-n-propylamine.

专利号:US-5124460-A
优先权日:1991-05-06
标 题 :Enantioselective synthesis of 3-substituted 1-azabicyclo (2.2.1)heptanes
发明人：HUMPHREY GUY R
权利人:MERCK SHARP & DOHME
摘要:A process for preparing a substantially pure enantiomer of a compound formula (I) ##STR1## wherein X is O or S; and n R 2 represents hydrogen, --CF 3 , --OR 7 , --SR 7 , --NR 7 R 8 , --CN, --COOR 7 , --CONR 7 R 8 , or a saturated or unsaturated, substituted or unsubstituted hydrocarbon group, wherein R 7 and R 8 are independently selected from hydrogen and C 1-2 alkyl provided that --NR 7 R 8 is other than NH 2 ; n which process comprises cyclization of a compound of formula (10) or salt thereof: ##STR2## wherein X and R 2 are as defined in formula (I); and R 4 is a labile leaving group and optionally epimerizing the endo-diastereomer so prepared to produce the corresponding exo-diastereomer.

专利号:US-2018179191-A1
优先权日:2016-11-22
标题 :Synthesis of a compound that modulates the activity of bromodomain-containing proteins
发明人：SHEN JINYU; ST JULES MUSTAPHA; SPERANDIO DAVID; MOHAN SANKAR
权利人:GILEAD SCIENCES INC
摘要:The present disclosure provides processes for the preparation of a compound of formula I: n n n n n n n n n n or a salt or co-crystal thereof, that modulates the activity of bromodomain-containing proteins. The disclosure also provides compounds and processes for the preparation of the compounds that are synthetic intermediates to the compound of formula I.