CAS: 555-16-8; 4-Nitrobenzaldehyde

上下游产品

CAS号636-98-6 4-硝基碘苯 | CAS号201230-82-2 carbon monoxide | CAS号619-72-7 对硝基苯甲腈 | CAS号619-73-8 对硝基苯甲醇 | CAS号2929-91-1 乙酸对硝基亚苄基 | CAS号122-04-3 对硝基苯甲酰氯 | CAS号24588-74-7 1,3-Dithiane,2-... | CAS号22391-06-6 4-nitrophenyl-1... | CAS号1734-79-8 反式-4-硝基肉桂醛 | CAS号108529-41-5 ethyl 4-[(4-nit... | CAS号105590-48-5 1-hydroxy-2-met... | CAS号104869-86-5 2-(4-nitropheny... | CAS号105590-51-0 2-[hydroxy-(4-n... | CAS号107484-31-1 1-[(4-nitrophen... | CAS号10480-05-4 Benzenamine,4-n... | CAS号105072-35-3 2-(4-nitropheny... | CAS号106053-85-4 methyl 2-azido-... | CAS号111955-89-6 N,N-dimethyl-4-... | CAS号1012-18-6 1-(2-methylprop...

氯霉素置于ruthenium Trichloride,Potassium Metaperiodate,Potassium Nitrate,Potassium Hydroxide体系中,用 水 作为反应溶剂,化学反应生成 对硝基苯甲醛
参考文献:钌(iii)在碱性水溶液中催化铜绿铜酸盐(iii)氧化氯霉素(一种抗菌药物)的动力学和机理
标题:钌(iii)在碱性水溶液中催化铜绿铜酸盐(iii)氧化氯霉素(一种抗菌药物)的动力学和机理
摘要:在恒定的离子强度为0.1 Mol L-1的碱性水溶液中,钌(iii)催化二氯十二酸铜(iii)(dpc)氧化氯霉素(chp)的动力学用分光光度法进行了研究.dpc和chp在碱性介质中的反应具有1:2的化学计量比(chp:Dpc).通过斑点测试,Ir,NMR和gc-Ms光谱研究确定了主要的氧化产物.关于钌(iii)和dpc浓度,反应是一级反应.随着氯霉素浓度的增加,氯霉素浓度的顺序从一阶到零阶变化.随着碱浓度的增加,反应速率随碱浓度的分数阶增加而增加.高碘酸盐浓度的增加降低了该速率.提出了一种充分描述观测到的规律性的机制.计算了机理不同步骤中涉及的反应常数.计算并讨论了有关机构限制步骤的激活参数.确定热力学量.
DOI:10.1134/s0023158411060085

专利信息

专利号:US-10189803-B2
优先权日:2008-02-22
标题 :Synthesis of therapeutic and diagnostic drugs centered on regioselective and stereoselective ring opening of aziridinium ions
发明人：CHONG HYUN-SOON
权利人:CHONG HYUN SOON; ILLINOIS INSTITUTE OF TECH
摘要:Stereoselective and regioselective synthesis of compounds via nucleophilic ring opening reactions of aziridinium ions for use in stereoselective and regioselective synthesis of therapeutic and diagnostic compounds.

专利号:WO-8800592-A1
优先权日:1986-07-18
标题:DIASTEROSELECTIVE STRECKER SYNTHESIS OF alpha-AMINOACIDS FROM GLYCOSYLAMINE DERIVATES
发明人：KUNZ HORST; SAGER WILFRIED; PFRENGE WALDEMAR; DECKER MATHIAS
权利人:CELAMERCK GMBH & CO KG
摘要:O-acyl-protected glycosylamines, in particular 2,3,4,6-tetra-O-pivaloyl-beta-D-galactopyranosylamine (1), their preparation and their use for the diastereoselective synthesis of alpha-aminoacids. With compounds such as (1), one can obtain by Strecker synthesis high yields and high diastereomer surplus. The direction of the asymmetric induction can be determined by the selection of the solvent. This type of synthesis is particularly effective when carried with Lewis acid catalysts. One obtains also high yields and high diastereoselectivity during Ugi four component synthesis facilitated by Lewis acids by using amines such as (1).

专利号:US-7589170-B1
优先权日:1998-09-25
标题 :Synthesis of cyclic peptides
发明人：SMYTHE MARK LESLIE; MEUTERMANS WIM DENIS FRANS; BOURNE GREGORY THOMAS; MCGEARY ROSS PETER
权利人:UNIV QUEENSLAND
摘要:This invention relates to methods for preparing cyclic peptides and peptidomimetic compounds in solution and bound to solid supports, and to cyclic peptide or peptidomimetic libraries for use in drug screening programs. In particular, the invention relates to a generic strategy for synthesis of cyclic peptides or peptidomimetics that enables the efficient synthesis under mild conditions of a wide variety of desired compounds. Two approaches were evaluated for their improvements in solution and solid phase synthesis of small cyclic peptides: positioning reversible N-amide substituents in the sequence; and applying native ligation chemistry in an intramolecular sense. Systematic investigation of the effects of preorganising peptides prior to cyclisation by using peptide cyclisation auxiliaries, and developing new linkers and peptide cyclisation auxiliaries to aid cyclic peptide synthesis gives surprising improvements in both yields and purity of products compared to the prior art methods. The combination of these technologies provides a powerful generic approach for the solution and solid phase synthesis of small cyclic peptides. The ring contraction and N-amide substitution technology of the invention provide improved methods for the synthesis of cyclic peptides and peptidomimetics. When used in conjunction with linker strategies, this combination provides solid-phase avenues to cyclic peptides and peptidomimetics.

专利号:US-2008032964-A1
优先权日:2006-04-10
标题:Process for the synthesis of azetidinone
发明人：KANSAL VINOD K; AHMAD SUHAIL; MARIAPPAN SHANMUGAVEL; TYAGI BHUPENDRA; PERLMAN NURIT; LE PAIH JACQUES; ZANOTTI-GEROSA ANTONIO
权利人:KANSAL VINOD K; AHMAD SUHAIL; MARIAPPAN SHANMUGAVEL; TYAGI BHUPENDRA; PERLMAN NURIT; LE PAIH JACQUES; ZANOTTI-GEROSA ANTONIO
摘要:Provided are intermediates useful for the synthesis of hydroxyl-alkyl substituted azetidinones, processes of their preparation, and processes for the synthesis of certain hydroxyl-alkyl substituted azetidinones. Also provided are processes for the synthesis of 1-(4-fluorophenyl)-3(R)-[3-(4-fluorophenyl)-3(S)-hydroxypropyl]-4(S)-(4-hydroxyphenyl)-2-azetidinone, or ezetimibe.

专利号:US-2004018598-A1
优先权日:2000-05-30
标题 :Bio-intermediates for use in the chemical synthesis of polyketides
发明人：SANTI DANIEL; ASHLEY GARY; MYLES DAVID C
摘要:The present invention relates to compounds made by a subset of modules from one or more polyketide synthase (“PKSâ€?) genes that are used as starting material in the chemical synthesis of novel molecules, particularly naturally occurring polyketides or derivatives thereof. The biologically derived intermediates (“bio-intermediatesâ€?) generally represent particularly difficult compounds to synthesize using traditional chemical approaches due to one or more stereocenters. In one aspect of the invention, an intermediate in the synthesis of epothilone is provided that feeds into the synthetic protocol of Danishefsky and co-workers. In another aspect of the invention, intermediates in the synthesis of discodermolide are provided that feed into the synthetic protocol of Smith and co-workers. By taking advantage of the inherent stereochemical specificity of biological processes, the syntheses of key intermediates and thus the overall syntheses of compounds like epothilone and discodermolide are greaty simplified.

专利号:US-6251689-B1
优先权日:1998-05-14
标 题:Methods for the solid phase synthesis of combinatorial libraries of benzimidazoles benzoxazoles benzothiazoles and derivatives thereof
发明人：LABORDE EDGARDO; MATSUMOTO YUKIHARU
权利人:TELIK INC
摘要:The present invention provides an efficient and versatile method for the synthesis and screening of combinatorial libraries of benzimidazoles, benzoxazoles, benzothiazoles, and derivatives thereof. In order to expedite the synthesis of large arrays of compounds possessing these core structures, a general methodology for solid phase synthesis of these derivatives is provided. Arrays of benzimidazoles, benzoxazoles, benzothiazoles, and derivatives thereof useful as peptidomimetics and for the identification of agents having antifungal, antiviral, antimicrobial, anticoagulant, and antiulcer activity, or use in the treatment of inflammation, hypertension, cancer, and other conditions can be prepared by this method.