CAS: 670-95-1; 4-Phenylimidazole

该化合物是有机化合物,其特点是有5个组成体的环形环形,含有两个氮原子;该化合物具有附属于该环第四位置的苯基组,具有独特性;该化合物一般是白色至白外晶状固体,在乙醇和二甲基硫氧化物等有机溶剂中可溶解,但水溶性有限;4-phenylimidazole因其在各种化学反应中,特别是在合成药物和农用化学物方面作为催化剂的作用而著称;此外,该化合物具有潜在的生物活动,包括抗硫化物和抗菌体特性;该化合物的结构允许与生物系统进行各种互动,使其对医药化学感兴趣;安全数据表明,与许多有机化合物一样,应谨慎地处理,因为如果加入或吸入,它可能会对健康造成危害.

结构式图片

相似化合物

13739-48-5 13569-96-5 670-91-7

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CAS号71759-89-2 4-碘咪唑 | CAS号98-80-6 苯硼酸 | CAS号2302-25-2 4-溴-1H-咪唑 | CAS号77287-34-4 甲亚胺酸 | CAS号70-11-1 2-溴苯乙酮 | CAS号15813-09-9 4,5-二碘-1H-咪唑 | CAS号1075-06-5 苯甲酰甲醛水合物 | CAS号563-96-2 乙醛酸,一水 | CAS号1074-12-0 苯基丙醇水合物 | CAS号100-47-0 苯甲腈 | CAS号611-73-4 苯甲酰甲酸 | CAS号65-85-0 苯甲酸 | CAS号24463-54-5 1-苯甲酰基-4-苯基咪唑 | CAS号699-02-5 2-(4-甲基苯基)乙醇 | CAS号3649-46-5 2-phenyl-5,6,7,... | CAS号858514-11-1 5-BROMO-4-PHENY... | CAS号362621-80-5 2,4-dibromo-5-p... | CAS号93667-93-7 3-(4-phenylimid... | CAS号53704-77-1 1-benzyl-4-phen...

合成工艺路线路线简述

    2-异亚硝基苯乙酮置于sodium Disulfite,氨,水体系中,化学反应生成 4-苯基咪唑
    参考文献:Pinner,Chemische Berichte,1902,Vol. 35,P. 4132
    标题:Pinner,Chemische Berichte,1902,Vol. 35,P. 4132

    海关参考信息

    专利信息


    专利号:US-8450365-B2
    优先权日:2009-05-12
    标 题 :Efficient synthesis of galanthamine
    发明人:MAGNUS PHILIP D; FAUBER BEN; SANE NEERAJ
    权利人:MAGNUS PHILIP D; FAUBER BEN; SANE NEERAJ; UNIV TEXAS
    摘要:The present invention relates to methods for the synthesis of galanthamine, morphine, intermediates, salts and derivatives thereof. In preferred embodiments, the invention relates to methods for improving the efficiency and overall yield of said morphine, morphine related derivatives and intermediates thereof. In further embodiments, the invention relates to methods for improving the efficiency and overall yield of galanthamine and intermediates thereof.

    专利号:US-2015133664-A1
    优先权日:2012-06-07
    标 题:Chemical transformations of (-)-codeine to afford derivatives of codeine and morphine thereof
    发明人:MAGNUS PHILIP; GHAVIMI-ALAGHA BAHMAN
    权利人:UNIV TEXAS
    摘要:The present invention relates to methods for the synthesis of morphine, codeine, intermediates, salts and derivatives thereof. In preferred embodiments, the invention relates to methods for improving the efficiency, steroselectivity, and overall yield of said codeine and morphine related derivatives and intermediates thereof. The present invention relates to new codeine and morphine related derivative compositions.

    专利号:US-7598394-B2
    优先权日:2003-11-11
    标题 :Process for the synthesis of imidazoles
    发明人:DOLBY LLOYD J; ESFANDIARI SHERVIN; GARST MICHAEL E
    权利人:ALLERGAN INC
    摘要:The present invention provides a process for the preparation of imidazoles by reacting a cyano compound with a silylalkylisocyanide compound. Such imidazoles are useful pharmacologically-active compounds and/or intermediates for the preparation of pharmacologically-active compounds.

    专利号:US-7880017-B2
    优先权日:2003-11-11
    标 题 :Process for the synthesis of imidazoles
    发明人:DOLBY LLOYD J; ESFANDIARI SHERVIN; GARST MICHAEL E
    权利人:ALLERGAN INC
    摘要:The present invention provides a process for the preparation of imidazoles by reacting a cyano compound with a silylalkylisocyanide compound. Such imidazoles are useful pharmacologically-active compounds and/or intermediates for the preparation of pharmacologically-active compounds.

    专利号:US-8889863-B2
    优先权日:2010-07-16
    标题:Stereoselective methods, catalysts and intermediates for the synthesis of (−)-Nutlin-3 and related compounds
    发明人:JOHNSTON JEFFREY N; DAVIS TYLER A
    权利人:JOHNSTON JEFFREY N; DAVIS TYLER A; UNIV VANDERBILT
    摘要:The present invention provides methods and intermediates are provided for the preparation of (−)-Nutlin-3. Methods and intermediates are also provided for the enantioselective addition of aryl nitromethanes to aldimines. Bis(amidine) catalysts for the use in these and other reactions are also provided.

    专利号:EP-1886695-A1
    优先权日:2006-06-27
    标 题:Pharmaceutical combination of an aldosterone synthase inhibitor and a glucocorticoid receptor antagonist or a cortisol synthesis inhibitor or a corticotropin releasing factor antagonist
    发明人:SCHUMACHER CHRISTOPH
    权利人:SPEEDEL EXPERIMENTA AG
    摘要:The invention relates to a pharmaceutical combination comprising (a) an aldosterone synthase inhibitor or a pharmaceutically acceptable salt thereof, and (b) a glucocorticoid receptor antagonist or a cortisol synthesis inhibitor or a cortisol re-synthesis inhibitor or a corticotrophin-releasing hormone receptor antagonist or combinations thereof or in each case a pharmaceutically acceptable salt thereof. Said composition is useful for the manufacture of a medicament, in particular for the manufacture of a medicament for the prevention of, delay of progression of treatment of a disease or condition characterized by the metabolic syndrome.
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    主要参考文献

    [参考文献]: D J Wolff, Et Al. Calmodulin-Dependent Nitric-Oxide Synthase. Mechanism Of Inhibition By Imidazole And Phenylimidazoles. J Biol Chem. 1993 May 5;268(13):9425-9.
    [参考文献]: Danni L Harris, Et Al. Theoretical Study Of The Ligand-Cyp2B4 Complexes: Effect Of Structure On Binding Free Energies And Heme Spin State. Proteins. 2004 Jun 1;55(4):895-914.
    [参考文献]: David J Nielsen, Et Al. 4-Phenyl-1H-Imidazole (A Low-Temperature Redetermination), 1-Benzyl-1H-Imidazole And 1-Mesityl-1H-Imidazole. Acta Crystallogr C. 2004 Aug;60(Pt 8):O542-4.
    [参考文献]: K K Hajek, Et Al. Spectral And Metabolic Properties Of Liver Microsomes From Imidazole-Pretreated Rabbits. Biochem Biophys Res Commun. 1982 Sep 30;108(2):664-72.
    [参考文献]: Larissa M Podust, Et Al. Small-Molecule Scaffolds For Cyp51 Inhibitors Identified By High-Throughput Screening And Defined By X-Ray Crystallography. Antimicrob Agents Chemother. 2007 Nov;51(11):3915-23.

    合成参考文献


    摘要:Wang, X.; Lu, X., Science of Synthesis: DNA-Encoded Libraries, (2024) nan, 243.
    参考文献:10.1021/jm990073x
    摘要:Muegge I, Martin YC, Hajduk PJ, Fesik SW. Evaluation of PMF scoring in docking weak ligands to the FK506 binding protein. J Med Chem. 1999 Jul 15;42(14):2498–503. doi: 10.1021/jm990073x.
    参考文献:10.1002/prot.20062
    摘要:Harris DL, Park JY, Gruenke L, Waskell L. Theoretical study of the ligand-CYP2B4 complexes: effect of structure on binding free energies and heme spin state. Proteins. 2004 Jun 01;55(4):895–914. doi: 10.1002/prot.20062.
    参考文献:10.1021/bi060193o
    摘要:Zhao B, Waterman MR, Isin EM, Sundaramoorthy M, Podust LM. Ligand-Assisted Inhibition in Cytochrome P450 158A2 from Streptomyces coelicolor A3(2),. Biochemistry. 2006 May 26;45(24):7493–500. doi: 10.1021/bi060193o.
    参考文献:10.1021/acs.biochem.6b00954
    摘要:Kavanagh ME, Chenge J, Zoufir A, McLean KJ, Coyne AG, Bender A, Munro AW, Abell C. Fragment Profiling Approach to Inhibitors of the Orphan M. tuberculosis P450 CYP144A1. Biochemistry. 2017 Mar 21;56(11):1559–72. doi: 10.1021/acs.biochem.6b00954.
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