CAS: 703-55-9; 1-Naphthylmagnesium Bromide

上下游产品

1-Bromonaphthalene H-naphthalen-1-one6-(2-dimethylamino-ethoxy)-3,4-dihydro-2H-naphthalen-1-one 4-bromo-2,3-dihydroinden-1-one magnesium 3-(Naphth-1-yl)propan-1-ol 1,2,3,4-Tetramethyl-phenanthren 4-(1-naphthyl)-4-oxobutanoic acid 2-(naphthalene-1-carbonyl)-benzoic acid

1-溴代萘置于碘,Magnesium体系中,用 四氢呋喃 作为反应溶剂,化学反应生成 1-萘基溴化镁,0.5M In Methf
参考文献:使用磺亚胺氟化物试剂快速反应生成 P(V)-f 键
标题:使用磺亚胺氟化物试剂快速反应生成 P(V)-f 键
摘要:磷-氟键在制药行业中变得越来越重要.为了继续他们的探索,需要更有效的合成方法.在这里,我们报告了氟化亚胺(sif)试剂在 P(V)-F 键合成中的应用. Sif 试剂可在短短 60 秒内促进次膦酸的脱氧氟化,具有出色的产率和范围.相同的 P(V)-f 产品也可以使用 Sif 试剂从二级氧化膦合成.
DOI:10.1021/acs.Orglett.3C00274

专利信息

专利号:WO-9964428-A1
优先权日:1998-06-10
标题:Synthesis of aryl boronic acids
发明人：SULLIVAN JEFFREY M; BARNES HAMLIN H
权利人:BOULDER SCIENT CO; SULLIVAN JEFFREY M; BARNES HAMLIN H
摘要:A method for synthesis of aryl boronic acids is disclosed.

专利号:WO-2014011120-A1
优先权日:2012-07-13
标 题 :Endoperoxides, synthesis and uses thereof for the treatment of neoplastic diseases such as cancer
发明人：TAN NGUAN SOON; CHIBA SHUNSUKE
权利人:UNIV NANYANG TECH
摘要:The present invention generally relates to processes and methods for the synthesis of endoperoxide compounds. More specifically, the invention relates to a method for preparing endoperoxide compounds starting from an aryl imine of formula (I) in the presence of a metallic catalyst and oxygen. The present invention also relates to endoperoxide compounds of formula (III) and their pharmaceutically acceptable salts thereof, useful for therapy. All substituents are defined herein. Also disclosed are methods of treating cancer using the compounds of formula (III).

专利号:US-8937184-B2
优先权日:2005-02-16
标 题:1H-imidazole derivatives as cannabinoid CB2 receptor modulators
发明人：LANGE JOSEPHUS H M; VAN STUIVENBERG HERMAN H; VAN VLIET BERNARD J
权利人:LANGE JOSEPHUS H M; VAN STUIVENBERG HERMAN H; VAN VLIET BERNARD J; ABBVIE BV
摘要:The invention relates to a group of 1H-imidazole derivatives which are modulators of cannabinoid CB 2 receptors, to methods for the preparation of these compounds, to novel intermediates useful for the synthesis of said imidazole derivatives, to methods for the preparation of these intermediates, to pharmaceutical compositions containing one or more of these 1H-imidazole derivatives as active ingredient, as well as to the use of these pharmaceutical compositions for the treatment of disorders in which cannabinoid CB 2 receptors are involved. n The compounds have the general formula (I) n nwherein R 1 -R 4 have the meanings given in the specification.

专利号:CN-109456201-A
优先权日:2018-11-12
标 题 :A kind of method for asymmetric synthesis of (R)-cinacalcet

专利号:CN-109456201-B
优先权日:2018-11-12
标 题 :A kind of method for asymmetric synthesis of (R)-cinacalcet

专利号:EP-1064286-A1
优先权日:1998-06-10
标 题:Synthesis of aryl boronic acids