CAS: 100-88-9; Cyclohexylsulfamic Acid

该化合物是合成甜食器,其甜度约为苏格罗塞的30至50倍;它是在水中溶解的白色晶状粉,适合各种食品和饮料用途;Cyclamate经常与其他甜剂结合使用,以提高甜度和改善口味特征;在热量下保持稳定,其储存寿命长,有利于加工食品的使用;然而,环球动物在安全方面一直引起争议;1970年代,由于担心潜在的致癌效应,在美国被禁用,尽管它仍然被许多其他国家批准使用;该物质通常存在于其钠或钙盐形式中,它有助于其糖性.Cyclamate没有被身体代谢,导致它被归类为非营养性甜食者,因此它是低卡路里和无糖产品的流行选择.

结构式图片

欧盟法规

REACH注册ECHA物质C&L通报REACH预注册

上下游产品

CAS号108-91-8 环己胺 | CAS号1122-60-7 硝基环己烷 | CAS号2211-64-5 N-环己基羟胺 | CAS号3173-53-3 环己基异氰酸酯 | CAS号10314-35-9 环己基氨基磺酰氯

合成工艺路线路线简述

  • 合成目标产物 Cyclamic Acid 主要起始原料 Cyclohexylamine
  • (文献来源)合成步骤主要原料 Cyclohexylamine
环己基异氰酸酯置于硫酸,三氧化硫体系中,化学反应生成环拉酸
参考文献:Process For Preparing Cyclohexylsulfamic Acid
标题:Process For Preparing Cyclohexylsulfamic Acid

专利信息


专利号:WO-0206209-A1
优先权日:2000-07-19
标 题 :Synthesis method for n1,n3-bis (2.aminoethyl) propane-1,3-diamine, synthesis intermediates, resulting products and use thereof in synthesis of cyclam
发明人:HANDEL HENRI; BERNARD HELENE; ANTOINE MARINE
权利人:UNIV BRETAGNE OCCIDENTALE; HANDEL HENRI; BERNARD HELENE; ANTOINE MARINE
摘要:The invention concerns a method of synthesis of a linear polynitrogen-containing derivative, namely N1,N3-bis (2-aminoethyl) propane-1,3-diamine of general formula (I) using as synthesis intermediates compounds (II) and (III). The invention also concerns the resulting products and their use in the synthesis of cyclic polynitrogen-containing derivatives such as cyclam.

专利号:US-9878313-B2
优先权日:2012-12-12
标题:One-pot method for the synthesis of Cu-SSZ-13, the compound obtained by the method and use thereof
发明人:MARIN MANUEL MOLINER; FRANCO RAQUEL MARTINEZ; CANÓS AVELINO CORMA; THØGERSEN JOAKIM REIMER
权利人:HALDOR TOPSOE AS
摘要:Process for the direct synthesis of Cu-SSZ-13 from a synthesis mixture comprising water, at least one silicon source, at least one Al source, at least one Cu source, at least one polyamine for complexing with Cu, and a single organic structure directing agent. A Cu containing molecular sieve having the framework structure of SSZ-13, obtainable by the process and use of the Cu containing molecular sieve.

专利号:US-9561498-B2
优先权日:2012-04-27
标 题 :Process for the direct synthesis of Cu-SAPO-34
发明人:FRANCO RAQUEL MARTINEZ; MARIN MANUEL MOLINER; CANÓS AVELINO CORMA; KUSTOV ARKADY; THØGERSEN JOAKIM REIMER
权利人:FRANCO RAQUEL MARTINEZ; MARIN MANUEL MOLINER; CANÓS AVELINO CORMA; KUSTOV ARKADY; THØGERSEN JOAKIM REIMER; HALDOR TOPSOE AS
摘要:A process for the direct synthesis of Cu-SAPO-34 comprising at least the steps: preparation of a mixture of water, at least one silicon source, at least one Al source, at least one P source, at least one Cu source, at least one 0SDA1 (any polyamine), and at least one OSDA2 source (where OSDA2 is any organic molecule capable of directing the synthesis of SAPO 34); and where the final synthesis mixture has the molar composition: a Si:0.5 Al:c Cu:d OSDA1:e OSDA2:f H2O wherein a is in the range from 0.01 to 0.3; b is in the range from 0.2 to 0.49; c is in the range from 0.001 to 0.6; d is in the range from 0.001 to 0.6; e is in the range from 0.001 to 2; f is in the range 1 to 200; hydrothermal treatment of the mixture at 80−200° C. until formation of the crystalline material, and recovery of the crystalline material.

专利号:US-9643915-B2
优先权日:2013-03-15
标题:Methods for the synthesis of sphingomyelins and dihydrosphingomyelins
发明人:ONICIU DANIELA CARMEN; HECKHOFF STEFAN; OSWALD BENOIT; REBMANN PETER; PEER ANDREAS; GONZALEZ MIGUEL; SAUTER PATRIK
权利人:CERENIS THERAPEUTICS HOLDING SA
摘要:The present invention includes methods for the synthesis of sphingomyelins and dihydrosphingomyelins. The present invention also includes methods for the synthesis of sphingosines and dihydrosphingosines. The present invention further includes methods for the synthesis of ceramides and dihydroceramides.

专利号:US-9708354-B2
优先权日:2013-03-15
标 题:Methods for the synthesis of sphingomyelins and dihydrosphingomyelins
发明人:ONICIU DANIELA CARMEN; HECKHOFF STEFAN; OSWALD BENOIT; REBMANN PETER; PEER ANDREAS; GONZALEZ MIGUEL; SAUTER PATRIK
权利人:CERENIS THERAPEUTICS HOLDING SA
摘要:The present invention includes methods for the synthesis of sphingomyelins and dihydrosphingomyelins. The present invention also includes methods for the synthesis of sphingosines and dihydrosphingosines. The present invention further includes methods for the synthesis of ceramides and dihydroceramides.

专利号:US-12162849-B2
优先权日:2018-12-21
标题 :Synthesis of 3-methyl-1,2,4-thiadiazole-5-carbohydrazide or of the methyl-d3 deuterated form thereof
发明人:HOVEYDA HAMID; DUTHEUIL GUILLAUME
权利人:OGEDA SA
摘要:The present invention relates to a method of synthesis of compound (I), wherein R1 represents methyl or methyl-d3, thus corresponding to 3-methyl-1,2,4-thiadiazole-5-carbohydrazide or to the methyl-d3 deuterated form thereof. These compounds are useful as key intermediates in the synthesis of pharmaceutical compounds, especially fezolinetant and deuterated fezolinetant.
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