4-Hydroxybenzyl 2-(2-Methoxyethoxy)Ethyl Ether置于iron(III) Chloride体系中,用97%的收率获得二乙二醇单甲醚 参考文献:Compounds And Methods Of Arylmethylation (Benzylation) As Protection For Alcohol Groups During Chemical Synthesis 标题:Compounds And Methods Of Arylmethylation (Benzylation) As Protection For Alcohol Groups During Chemical Synthesis 摘要:一种对醇进行苄基化的过程包括将2-苄氧基-1-甲基吡啶三氟甲磺酸盐与具有预定沸点的芳香烃溶剂混合;向混合物中加入酸中和剂;将待苄基化的醇与混合物结合;通过加热至高于环境温度使醇与2-苄氧基-1-甲基吡啶三氟甲磺酸盐发生反应以生成苄基化醇;并将苄基化醇与混合物分离.
专利号:US-7825244-B2 优先权日:2005-06-10 标题:Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators, and related methods of synthesis 发明人:BAINDUR NAND; GAUL MICHAEL DAVID; KREUTTER KEVIN DOUGLAS; XU GUOZHANG 权利人:JANSSEN PHARMACEUTICA NV 摘要:The invention is directed to alkylquinoline and alkylquinazoline compounds of Formula C: n nwherein R 1 , R 2 , R 99 , and X are as defined herein, the use of such compounds in the synthesis of protein tyrosine kinase inhibitors, particularly inhibitors of FLT3 and/or c-kit and/or TrkB.
专利号:US-2012029226-A1 优先权日:2009-02-06 标题:Method for the synthesis of chiral alpha-aryl propionic acid derivatives 发明人:KAPTEIN BERNARDUS; VLIEG ELIAS; NOORDUIN WILLEM LIEUWE 权利人:KAPTEIN BERNARDUS; VLIEG ELIAS; NOORDUIN WILLEM LIEUWE 摘要:The present invention provides a method for the synthesis of optically pure α-aryl propionic acid derivatives comprising subjecting the corresponding racemic α-aryl propionic acid derivatives to high sheer or impact forces, such as grinding.
专利号:US-9328109-B2 优先权日:2013-01-14 标 题:Process for the preparation of benzohetero [1, 3] diazole compounds disubstituted with heteroaryl groups 发明人:BIANCHI GABRIELE; PO' RICCARDO 权利人:ENI SPA 摘要:Process for the preparation of a benzohetero-[1,3]diazole compound disubstituted with brominated heteroaryl groups which comprises reacting at least one dihalogenated benzohetero[1,3]diazole compound with at least one brominated heteroaryl compound. Said benzohetero[1,3]diazole compound disubstituted with brominated heteroaryl groups can be advantageously used in the synthesis of compounds useful in the construction of solar concentrators (LSCs—“Luminescent Solar Concentratorsâ€?). Furthermore, said benzohetero[1,3]diazole compound disubstituted with brominated heteroaryl groups can be advantageously used in the synthesis of photoactive polymers useful in the construction of photovoltaic devices (or solar devices) such as, for example, photovoltaic cells (or solar cells), photovoltaic modules (or solar modules), on both rigid or flexible supports. Furthermore, said benzohetero[1,3]diazole compound disubstituted with brominated heteroaryl groups can be advantageously used as precursor of monomeric units in the synthesis of semiconductr polymers.
专利号:US-5914388-A 优先权日:1995-04-26 标题:Synthesis polyphosphazenes with controlled molecular weight and polydisperity 发明人:ALLCOCK HARRY R; MORRISSEY CHRISTOPHER T; MANNERS IAN; HONEYMAN CHARLES H; NELSON JAMES M; CRANE CHESTER A; REEVES SCOTT D; PRIMROSE A PAUL; HARTLE THOMAS J; PRANGE R 权利人:PENN STATE RES FOUND 摘要:A process for the preparation of polyphosphazenes is provided that includes the cationic solution polymerization reaction of a phosphoranimine, using a main group or transition metal halide, or other appropriate halide salt, including a linear phosphazene salt of any chain length, or a preformed non-phosphazene polymer containing a main or transition metal chloride, as an initiator. In a preferred embodiment, triarmed-star polyphosphazenes having the formula N{RN(H)R'2P-(N=PR'2)n}3 are prepared via this method. Also, a methods for synthesis of the monomer Cl3P=NSiMe3 and cyclic trimer N3P3X6 from the reactants N(SiR3)3 and PX5 are also described.
专利号:US-5698664-A 优先权日:1995-04-26 标题 :Synthesis of polyphosphazenes with controlled molecular weight and polydispersity 发明人:ALLCOCK HARRY R; MORRISSEY CHRISTOPHER T; MANNERS IAN; HONEYMAN CHARLES H 权利人:PENN STATE RES FOUND; UNIV TORONTO 摘要:A process for the preparation of polyphosphazenes is provided that includes the cationic solution polymerization reaction of a phosphoranimine, using a main group or transition metal halide, or other appropriate halide salt, including a linear phosphazene salt of any chain length, or a preformed nonphosphazene polymer containing a main or transition metal chloride, as an initiator.
[参考文献]: An S, Et Al. Small-Molecule Protacs: An Emerging And Promising Approach For The Development Of Targeted Therapy Drugs. Ebiomedicine. 2018 Oct;36:553-562
合成参考文献
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