CAS: 113305-94-5; 5-Aminopyrazine-2-Carbonitrile

相似化合物

40155-43-9 89323-09-1 1965308-99-9

上下游产品

CAS号59489-71-3 2-氨基-5-溴吡嗪 | CAS号151-50-8 氰化钾 | CAS号143-33-9 氰化钠 | CAS号544-92-3 氰化亚铜 | CAS号1276056-81-5 咪唑并[1,2-a]吡嗪-6-甲腈 | CAS号221295-04-1 2-溴-5-氰基吡嗪

2-氨基-5-溴吡嗪置于pd(Pph3)4 Cui体系中,用 N-甲基乙酰胺 用作溶剂,以60%的收率获得2-氨基-5-氰基吡嗪
参考文献:Compounds Useful For Inhibiting Chk1
标题:Compounds Useful For Inhibiting Chk1
摘要:公开了芳基和杂芳基取代脲化合物,用于治疗与dna损伤或dna复制中dna损伤有关的疾病和状况.还公开了制造这些化合物的方法,以及它们作为治疗剂的使用,例如,在治疗由dna复制,染色体分离或细胞分裂缺陷引起的癌症和其他疾病.

专利信息

专利号:US-2023150994-A1
优先权日:2020-04-07
标 题:Methods for synthesis of chk1 inhibitors
发明人：SCHWAEBE MICHAEL; ROSNER THORSTEN; ZHAO DALIAN; MILLER ROSS; DULINA RICH; HUMORA MICHAEL; GOTTSCHLING STEPHEN E
权利人:SIERRA ONCOLOGY INC
摘要:The present technology relates to processes, compounds, compositions, and methods useful for coupling reactions. Also, the present disclosure provides for novel intermediates, compositions of matter, and processes relating to the Chk1 inhibitor, SRA737.

专利号:EP-4132922-A1
优先权日:2020-04-07
标 题 :Methods for synthesis of chk1 inhibitors

专利号:US-12428395-B2
优先权日:2019-08-01
标题 :Heterocyclic compounds as kinase inhibitor and uses thereof
发明人：PENDHARKAR DHANANJAY; RAMACHANDRAN SREEKANTH A; JADHAVAR PRADEEP S; PANPATIL DAYANAND; SAEED UZMA; KUMAR VIVEK; BIST DIPSHE
权利人:SPEROGENIX THERAPEUTICS LTD
摘要:The present disclosure relates generally to compounds useful in treatment of conditions associated with Checkpoint kinase (CHK), particularly CHK-1 enzymes. Specifically, the present invention discloses compound of formula (IA), which exhibits inhibitory activity against CHK-1 enzymes. Methods of treating conditions associated with excessive activity of CHK-1 enzymes with such compounds is disclosed. Uses thereof, pharmaceutical compositions, kits and method of synthesis also disclosed.

专利号:WO-2022162606-A1
优先权日:2021-01-30
标 题:Heterocyclic compounds as kinase inhibitor and uses thereof
发明人：YAN ZHIYU; WANG XIAOHUI; LIU HANLAN; KHAN PASHA M; PANPATIL DAYANAND; PUJALA BRAHMAM; PENDHARKAR DHANANJAY; JADHAVAR PRADEEP S; SAEED UZMA; KUMAR VIVEK
权利人:SPEROGENIX THERAPEUTICS LTD; INTEGRAL BIOSCIENCES PRIVATE LTD
摘要:The present disclosure relates generally to compounds useful in treatment of conditions associated with Checkpoint kinase (CHK), particularly CHK-1 enzymes. Specifically, the present invention discloses compound of formula (J), which exhibits inhibitory activity against CHK-1 enzymes. Methods of treating conditions associated with excessive activity of CHK-1 enzymes such as cancer, idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH) with such compounds is disclosed. Uses thereof, pharmaceutical compositions, kits and method of synthesis also disclosed. Formula (J)