CAS: 1218779-75-9; N-[4-(1-Cyanocyclopentyl)Phenyl]-2-[(4-Pyridinylmethyl)Amino]Nico Tinamide

甲烷磺酸,阿帕替尼 以 水,异丙醇 用作溶剂,以85.4%的收率获得甲磺酸阿帕替尼
参考文献:The Salts Of N-[4-(1-Cyanocyclopentyl)Phenyl]-2-(4-Pyridylmethyl)Amino-3-Pyridinecarboxamide
标题:The Salts Of N-[4-(1-Cyanocyclopentyl)Phenyl]-2-(4-Pyridylmethyl)Amino-3-Pyridinecarboxamide
摘要:本发明涉及n-[4-(1-氰基环戊基)苯基]-2-(4-吡啶甲基)氨基-3-吡啶羧酰胺的盐,特别是其盐酸盐和甲磺酸盐,以及该盐在制备抗肿瘤药物中的应用.

专利信息

专利号:WO-2023098592-A1
优先权日:2021-11-30
标题:Preparation method for carbon-loaded iron-based catalyst and use thereof in synthesis of intermediates of anti-cancer inhibitors

专利号:US-12390420-B1
优先权日:2024-10-22
标题 :Compositions for targeted delivery of therapeutic agents and methods for the synthesis and use thereof
发明人：EGUCHI MASAKATSU
权利人:BRYET US INC
摘要:The present disclosure provides compositions and methods for delivering therapeutic agents to particular tissues or cells in a subject. The composition disclosed herein combines unique properties of porous micro- or nano-particles with host-guest chemistry provided by functionalized silicon particle, offering a versatile approach to addressing the challenges associated with delivering therapeutic agents to target tissues or sites within the body. The present disclosure also provides a method for synthesizing a composition capable of delivering therapeutic agents to particular tissues or cells in a subject.

专利号:CN-114315595-B
优先权日:2021-11-30
标题 :Preparation method of a carbon-supported iron-based catalyst and its application in the synthesis of anti-cancer inhibitor intermediates

专利号:US-10272065-B2
优先权日:2013-01-14
标题 :Gem-difluorinated C-glycoside compounds as anti-cancer agents
发明人：SLILATY STEVE N
权利人:ADVANOMICS CORP; BENOIT & COTE
摘要:The present document describes a synthesis of a class of gem-difluorinated C-glycoside compounds derived from podophyllotoxin, which may be used, but not exclusively, in oncology for the treatment of cancer. More particularly, the podophyllotoxin gem-difluorinated C-glycoconjugated derivatives display improved conformational and chemical stability, and improved cytotoxicity exhibited against drug-resistant cancer cell lines.

专利号:US-2022233727-A1
优先权日:2019-06-13
标题:Surface enhanced raman scattering nanoparticles and their use in detecting and imaging oxidative stress
发明人：THAKOR AVNESH S; RAZAVI MEHDI
权利人:UNIV LELAND STANFORD JUNIOR
摘要:Surface enhanced Raman scattering (SERS) nanoparticles and methods of using them for detecting reactive oxygen species are disclosed. In particular, methods of using SERS nanoparticles to detect and quantify reactive oxygen species Synthesis and monitor oxidative stress and disease-relevant changes in levels of reactive oxygen species are provided.

专利号:CN-114315595-A
优先权日:2021-11-30
标题:Preparation method of carbon-supported iron-based catalyst and synthesis application of anti-cancer inhibitor intermediate thereof