CAS: 16883-16-2; 5-Methyl-3-Phenylisoxazole-4-Carbonyl Chloride

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CAS号1136-45-4 5-甲基-3-苯基异恶唑-4-羧酸 | CAS号35166-26-8 5-methyl-3-phen... | CAS号2065-28-3 5-甲基-3-苯基-4-异恶唑甲酸甲酯 | CAS号100-52-7 苯甲醛 | CAS号698-16-8 邻氯苯甲醛肟 | CAS号932-90-1 苯甲醛肟 | CAS号341001-38-5 [4-(2-氯-4-硝基苯基)... | CAS号14677-93-1 Methanone,(5-me... | CAS号268748-84-1 5-甲基-3-苯基-4-异恶唑酰异氰酸酯 | CAS号66-79-5 苯唑西林 | CAS号1173-88-2 苯唑西林钠 | CAS号2065-28-3 5-甲基-3-苯基-4-异恶唑甲酸甲酯 | CAS号18336-75-9 5-甲基-3-苯基-4-异噁唑碳酰肼 | CAS号64769-68-2 Isoxazolo[4,5-c... | CAS号99299-07-7 (5-Ethyl-3-phen... | CAS号4340-44-7 5-Methyl-3-phen...

1-苯基-3-丁烯-1-醇置于n-溴代丁二酰亚胺(Nbs),Jones Reagent,正丁基锂,氯化亚砜,盐酸羟胺,Sodium Acetate,Palladium Diacetate,Silver Carbonate,Potassium Hydroxide体系中,用 四氢呋喃,甲醇,乙醚,乙醇,正己烷,水,N,N-二甲基甲酰胺,氯苯 用作溶剂,化学反应 10.75H,反应生成5-甲基-3-苯基-4-异唑甲酰氯
参考文献:肟介导的5-甲基异恶唑的简便合成及其在伐地昔布和奥沙西林合成中的应用
标题:肟介导的5-甲基异恶唑的简便合成及其在伐地昔布和奥沙西林合成中的应用
摘要:描述了通过肟介导的未活化烯烃的钯催化的5-甲基异恶唑的有效合成.该反应以中等至非常好的收率提供了多种5-甲基异恶唑.为了进一步证明该方法的实用性,报道了伐地昔布和奥沙西林的快速合成.
Doi:10.1021/ol502246T

专利信息

专利号:US-4271172-A
优先权日:1979-06-25
标 题 :6-Amino-spiro[penam-2,4'-piperidine]-3-carboxylic acids, antibacterial compositions thereof and method of use thereof
发明人：RODRIGUEZ LUDOVIC; LECLERCQ JACQUES; YKMAN PIERRE; COSSEMENT ERIC
权利人:UCB SA
摘要:6-Amino-spiro[penam-2,4'-piperidine]-3-carboxylic acids, salts and esters thereof of the formula ##STR1## wherein R 1 is hydrogen, benzyl or an alkali metal or ammonium ion and R 2 is methyl, phenyl or benzyl and process for preparing the same. n These compounds are useful as intermediates in the synthesis of a new group of antibiotics having properties similar to penicillins, besides own antibiotic activity with a broad antibacterial spectrum. Therefore, they are useful as antibacterials agents and as therapeutic agents for humans and for animals in the treatment of infectious diseases caused by Gram-positive and Gram-negative bacteria.

专利号:US-4348264-A
优先权日:1980-05-14
标 题 :Photocatalyzed process for producing carbapenams and carbapen-2-ems
发明人：ROSATI ROBERT L
权利人:PFIZER
摘要:Carbapenam-3-carboxylic acids and carbapen-2-em-3-carboxylic acids substituted at the 1-position with an oxo, a hydroxy or an acetoxy group, variously substituted at the 2-position with such groups as methyl, acetoxymethyl, methanesulfonyloxy, alkoxy, alkylthio, aminoalkylthio or amidinoalkylthio and optionally substituted at the 6-position with a hydroxyalkyl group, an acetoxyalkyl group or a conventional penicillin side-chain, pharmaceutically-acceptable salts thereof and various esters thereof wherein the esterifying group is selectively removed in the laboratory, or hydrolyzed under physiological conditions. n These compounds are useful either systemically or topically in the treatment of diseases caused by susceptible microorganisms, as animal feed additives for promotion of growth, or in the preservation of biodegradable materials, or as intermediates to compounds having such antibacterial activity. n Key to the synthesis of these compounds is the light catalyzed rearrangement of 2-diazo-1-oxoceph-3-em-4-carboxylates to 1-oxocarbapen-2-em-3-carboxylates, a newly discovered reaction determined to be of general applicability.

专利号:US-4429128-A
优先权日:1981-02-09
标题 :Carbapenams and carbapen-2-ems and process therefor
发明人：ROSATI ROBERT L
权利人:PFIZER
摘要:Carbapenam-3-carboxylic acids and carbapen-2-em-3-carboxylic acids substituted at the 1-position with an oxo, a hydroxy or an acetoxy group, variously substituted at the 2-position with such groups as methyl, acetoxymethyl, methanesulfonyloxy, alkoxy, alkylthio, aminoalkylthio or amidinoalkylthio and optionally substituted at the 6-position with a hydroxyalkyl group, an acetoxyalkyl group or a conventional penicillin side-chain, pharmaceutically-acceptable salts thereof and various esters thereof wherein the esterifying group is selectively removed in the laboratory, or hydrolyzed under physiological conditions. n These compounds are useful either systemically or topically in the treatment of diseases caused by susceptible microorganisms, as animal feed additives for promotion of growth, or in the preservation of biodegradable materials, or as intermediates to compounds having such antibacterial activity. n Key to the synthesis of these compounds is the light catalyzed rearrangement of 2-diazo-1-oxoceph-3-em-4-carboxylates to 1-oxocarbapen-2-em-3-carboxylates, a newly discovered reaction determined to be of general applicability.

专利号:US-4137236-A
优先权日:1977-01-18
标 题:Amino-spiro[oxa(or thia)cycloalkane-penam]-carboxylic
发明人：RODRIGUEZ LUDOVIC; LECLERCA JACQUES; YKMAN PIERRE; COSSEMENT ERIC
权利人:UCB SA
摘要:Amino-spiro[oxa(or thia)cycloalkane-penam]-carboxylic acid, a salt or an ester thereof, of the formula ##STR1## wherein Z is a hydrogen or an alkali metal atom, or a group protecting the carboxylic function, X is a sulfur or oxygen atom, n is 1 or 2, m is 1 or 2, and process of preparing the same. n These compounds are useful as intermediates in the synthesis of a new group of antibiotics having properties similar to penicillins, besides own antibiotic activity with a broad antibacterial spectrum.

专利号:US-4091027-A
优先权日:1976-05-25
标 题 :6'-Amino-spiro(cycloalkane-1,2'-penam)-3'-carboxylic acids
发明人：RODRIGUEZ LUDOVIC; LECLERCQ JACQUES
权利人:UCB SA
摘要:6'-Amino-spiro[cycloalkane-1,2'-penam]-3'-carboxylic acids of the formula ##STR1## WHEREIN Z is a hydrogen or an alkali metal atom, or a protective group, and n a whole number of from 3 to 6, and process of preparing the same. n These compounds are useful as intermediates in the synthesis of a new group of antibiotics having properties similar to the penicillins.

专利号:US-3989685-A
优先权日:1972-06-29
标题 :Process for making a 2'-halopenicillin
发明人：TANIDA HIROSHI; TSUJI TERUJI
权利人:SHINOGI CO
摘要:A 2'-halopenicillin compound is prepared from a penicillin-1-oxide compound by the action of an acid halide in the presence of a base. The product on heating rearranges to a 3-halo-3-methylcepham compound which itself gives a 3-methyl-3-cephem compound on further heating. A 2'-halopenicillin compound gives a 3-methyl-3-cephem compound on heating. The 2'-halopenicillin compounds, 3-halo-3-methylcepham compound and 3-methyl-3-cephem compounds are antibacterials which are also useful as intermediates for the synthesis of other penicillins and cephalosporins.